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Stimulation of proinflammatory cytokines by volatile sulfur compounds in endodontically treated teeth.

Lechner J, von Baehr V - Int J Gen Med (2015)

Bottom Line: Persistent microorganisms in endodontically treated teeth produce volatile sulfur compounds (VSC) such as methyl mercaptan, hydrogen sulfide, and thioether.Data elucidate the role of VSC in patients with immunologic diseases and the role of a semiquantitative chairside test, like the VSC indicator presented here, in correlation to IFNg and IL-10 sensitization in peripheral blood mononuclear cells.The association between ex vivo-stimulated cytokines and endodontically derived sulfur components is supported by the fact that the number of interferon gamma- and/or interleukin-10-positive sensitized patients declined significantly 3-8 months after extraction of the corresponding teeth.

View Article: PubMed Central - PubMed

Affiliation: Clinic for Integrative Dentistry, Munich, Germany.

ABSTRACT
Persistent microorganisms in endodontically treated teeth produce volatile sulfur compounds (VSC) such as methyl mercaptan, hydrogen sulfide, and thioether. In this retrospective study, we evaluated the ex vivo immune response of peripheral blood mononuclear cells to sulfur compounds in 354 patients with systemic diseases. These systemic findings are correlated with semiquantitative values of a VSC indicator applied directly on endodontically treated teeth. Data elucidate the role of VSC in patients with immunologic diseases and the role of a semiquantitative chairside test, like the VSC indicator presented here, in correlation to IFNg and IL-10 sensitization in peripheral blood mononuclear cells. The association between ex vivo-stimulated cytokines and endodontically derived sulfur components is supported by the fact that the number of interferon gamma- and/or interleukin-10-positive sensitized patients declined significantly 3-8 months after extraction of the corresponding teeth.

No MeSH data available.


Related in: MedlinePlus

Mean IL-10 levels before and after the extraction of RFT in patients with systemic diseases.Notes: Comparison of mean IL-10 levels before (with RFT) and after removal of RFT (without RFT). The study group is comprised of patients with systemic diseases (n=14) and error bars indicate standard error of mean. *2.3-fold change.Abbreviation: RFT, root-filled teeth.
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f6-ijgm-8-109: Mean IL-10 levels before and after the extraction of RFT in patients with systemic diseases.Notes: Comparison of mean IL-10 levels before (with RFT) and after removal of RFT (without RFT). The study group is comprised of patients with systemic diseases (n=14) and error bars indicate standard error of mean. *2.3-fold change.Abbreviation: RFT, root-filled teeth.

Mentions: For IL-10, the postextraction group with persisting RFT exhibited a mean IL-10 sensitization of 63.71 IU/mL (SD ±65.3), and those with extracted RFT showed a remaining mean IL-10 sensitization level of 27.41 IU/mL (SD ±34.3); this was not statistically significant (P<0.133). Nevertheless, a comparison of the mean values obtained from the total of the sensitization indices before and after the extraction of RFT showed a reduction in IL-10 sensitization by a factor of 2.31 (63.71:27.41) (Figure 6).


Stimulation of proinflammatory cytokines by volatile sulfur compounds in endodontically treated teeth.

Lechner J, von Baehr V - Int J Gen Med (2015)

Mean IL-10 levels before and after the extraction of RFT in patients with systemic diseases.Notes: Comparison of mean IL-10 levels before (with RFT) and after removal of RFT (without RFT). The study group is comprised of patients with systemic diseases (n=14) and error bars indicate standard error of mean. *2.3-fold change.Abbreviation: RFT, root-filled teeth.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4362895&req=5

f6-ijgm-8-109: Mean IL-10 levels before and after the extraction of RFT in patients with systemic diseases.Notes: Comparison of mean IL-10 levels before (with RFT) and after removal of RFT (without RFT). The study group is comprised of patients with systemic diseases (n=14) and error bars indicate standard error of mean. *2.3-fold change.Abbreviation: RFT, root-filled teeth.
Mentions: For IL-10, the postextraction group with persisting RFT exhibited a mean IL-10 sensitization of 63.71 IU/mL (SD ±65.3), and those with extracted RFT showed a remaining mean IL-10 sensitization level of 27.41 IU/mL (SD ±34.3); this was not statistically significant (P<0.133). Nevertheless, a comparison of the mean values obtained from the total of the sensitization indices before and after the extraction of RFT showed a reduction in IL-10 sensitization by a factor of 2.31 (63.71:27.41) (Figure 6).

Bottom Line: Persistent microorganisms in endodontically treated teeth produce volatile sulfur compounds (VSC) such as methyl mercaptan, hydrogen sulfide, and thioether.Data elucidate the role of VSC in patients with immunologic diseases and the role of a semiquantitative chairside test, like the VSC indicator presented here, in correlation to IFNg and IL-10 sensitization in peripheral blood mononuclear cells.The association between ex vivo-stimulated cytokines and endodontically derived sulfur components is supported by the fact that the number of interferon gamma- and/or interleukin-10-positive sensitized patients declined significantly 3-8 months after extraction of the corresponding teeth.

View Article: PubMed Central - PubMed

Affiliation: Clinic for Integrative Dentistry, Munich, Germany.

ABSTRACT
Persistent microorganisms in endodontically treated teeth produce volatile sulfur compounds (VSC) such as methyl mercaptan, hydrogen sulfide, and thioether. In this retrospective study, we evaluated the ex vivo immune response of peripheral blood mononuclear cells to sulfur compounds in 354 patients with systemic diseases. These systemic findings are correlated with semiquantitative values of a VSC indicator applied directly on endodontically treated teeth. Data elucidate the role of VSC in patients with immunologic diseases and the role of a semiquantitative chairside test, like the VSC indicator presented here, in correlation to IFNg and IL-10 sensitization in peripheral blood mononuclear cells. The association between ex vivo-stimulated cytokines and endodontically derived sulfur components is supported by the fact that the number of interferon gamma- and/or interleukin-10-positive sensitized patients declined significantly 3-8 months after extraction of the corresponding teeth.

No MeSH data available.


Related in: MedlinePlus