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Stimulation of proinflammatory cytokines by volatile sulfur compounds in endodontically treated teeth.

Lechner J, von Baehr V - Int J Gen Med (2015)

Bottom Line: Persistent microorganisms in endodontically treated teeth produce volatile sulfur compounds (VSC) such as methyl mercaptan, hydrogen sulfide, and thioether.Data elucidate the role of VSC in patients with immunologic diseases and the role of a semiquantitative chairside test, like the VSC indicator presented here, in correlation to IFNg and IL-10 sensitization in peripheral blood mononuclear cells.The association between ex vivo-stimulated cytokines and endodontically derived sulfur components is supported by the fact that the number of interferon gamma- and/or interleukin-10-positive sensitized patients declined significantly 3-8 months after extraction of the corresponding teeth.

View Article: PubMed Central - PubMed

Affiliation: Clinic for Integrative Dentistry, Munich, Germany.

ABSTRACT
Persistent microorganisms in endodontically treated teeth produce volatile sulfur compounds (VSC) such as methyl mercaptan, hydrogen sulfide, and thioether. In this retrospective study, we evaluated the ex vivo immune response of peripheral blood mononuclear cells to sulfur compounds in 354 patients with systemic diseases. These systemic findings are correlated with semiquantitative values of a VSC indicator applied directly on endodontically treated teeth. Data elucidate the role of VSC in patients with immunologic diseases and the role of a semiquantitative chairside test, like the VSC indicator presented here, in correlation to IFNg and IL-10 sensitization in peripheral blood mononuclear cells. The association between ex vivo-stimulated cytokines and endodontically derived sulfur components is supported by the fact that the number of interferon gamma- and/or interleukin-10-positive sensitized patients declined significantly 3-8 months after extraction of the corresponding teeth.

No MeSH data available.


Related in: MedlinePlus

Calculation of total VSCI value in a representative patient with four RFTs.Notes: VSCI values obtained after semiquantitative analysis were 0, 3, 2, and 3, respectively, in four RFTs. The total VSCI value equals 8 corresponding to total toxin levels in this patient.Abbreviations: RFTs, root-filled teeth; VSCI, volatile sulfur compound indicator.
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f3-ijgm-8-109: Calculation of total VSCI value in a representative patient with four RFTs.Notes: VSCI values obtained after semiquantitative analysis were 0, 3, 2, and 3, respectively, in four RFTs. The total VSCI value equals 8 corresponding to total toxin levels in this patient.Abbreviations: RFTs, root-filled teeth; VSCI, volatile sulfur compound indicator.

Mentions: In order to measure and compare the total toxin levels among individuals in the sensitized and nonsensitized groups, the local toxin values obtained from the VSCI were totaled for each of the 354 patients. Thus, if a sensitized patient had four RFT with VSCI values of 0, 3, 2, and 3, respectively, his load of 8 was added to the total VSCI values obtained from the 182 sensitized patients. The individual VSCI values from the group of nonsensitized patients (n=172) were evaluated in the same way. VSCI values represent a grading system, and are thus not defined by units (see Figure 3).


Stimulation of proinflammatory cytokines by volatile sulfur compounds in endodontically treated teeth.

Lechner J, von Baehr V - Int J Gen Med (2015)

Calculation of total VSCI value in a representative patient with four RFTs.Notes: VSCI values obtained after semiquantitative analysis were 0, 3, 2, and 3, respectively, in four RFTs. The total VSCI value equals 8 corresponding to total toxin levels in this patient.Abbreviations: RFTs, root-filled teeth; VSCI, volatile sulfur compound indicator.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4362895&req=5

f3-ijgm-8-109: Calculation of total VSCI value in a representative patient with four RFTs.Notes: VSCI values obtained after semiquantitative analysis were 0, 3, 2, and 3, respectively, in four RFTs. The total VSCI value equals 8 corresponding to total toxin levels in this patient.Abbreviations: RFTs, root-filled teeth; VSCI, volatile sulfur compound indicator.
Mentions: In order to measure and compare the total toxin levels among individuals in the sensitized and nonsensitized groups, the local toxin values obtained from the VSCI were totaled for each of the 354 patients. Thus, if a sensitized patient had four RFT with VSCI values of 0, 3, 2, and 3, respectively, his load of 8 was added to the total VSCI values obtained from the 182 sensitized patients. The individual VSCI values from the group of nonsensitized patients (n=172) were evaluated in the same way. VSCI values represent a grading system, and are thus not defined by units (see Figure 3).

Bottom Line: Persistent microorganisms in endodontically treated teeth produce volatile sulfur compounds (VSC) such as methyl mercaptan, hydrogen sulfide, and thioether.Data elucidate the role of VSC in patients with immunologic diseases and the role of a semiquantitative chairside test, like the VSC indicator presented here, in correlation to IFNg and IL-10 sensitization in peripheral blood mononuclear cells.The association between ex vivo-stimulated cytokines and endodontically derived sulfur components is supported by the fact that the number of interferon gamma- and/or interleukin-10-positive sensitized patients declined significantly 3-8 months after extraction of the corresponding teeth.

View Article: PubMed Central - PubMed

Affiliation: Clinic for Integrative Dentistry, Munich, Germany.

ABSTRACT
Persistent microorganisms in endodontically treated teeth produce volatile sulfur compounds (VSC) such as methyl mercaptan, hydrogen sulfide, and thioether. In this retrospective study, we evaluated the ex vivo immune response of peripheral blood mononuclear cells to sulfur compounds in 354 patients with systemic diseases. These systemic findings are correlated with semiquantitative values of a VSC indicator applied directly on endodontically treated teeth. Data elucidate the role of VSC in patients with immunologic diseases and the role of a semiquantitative chairside test, like the VSC indicator presented here, in correlation to IFNg and IL-10 sensitization in peripheral blood mononuclear cells. The association between ex vivo-stimulated cytokines and endodontically derived sulfur components is supported by the fact that the number of interferon gamma- and/or interleukin-10-positive sensitized patients declined significantly 3-8 months after extraction of the corresponding teeth.

No MeSH data available.


Related in: MedlinePlus