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Hypodontia phenotype in patients with epithelial ovarian cancer.

Fekonja A, Cretnik A, Zerdoner D, Takac I - Radiol Oncol (2015)

Bottom Line: Ovarian cancer is usually diagnosed in an advanced stage and the present clinical and diagnostic molecular markers for early OC screening are insufficient.A retrospective study was conducted on 120 patients with EOC treated at the Department of Gynaecologic and Breast Oncology at the University Clinical Centre and 120 gynaecological healthy women (control group) of the same mean age.We also found statistically significant difference between the ovarian cancer group and control group in presence of other malignant tumours in subjects (p < 0.001).

View Article: PubMed Central - PubMed

Affiliation: Department of Orthodontics, Health Centre Maribor, Maribor, Slovenia.

ABSTRACT

Background: Ovarian cancer is usually diagnosed in an advanced stage and the present clinical and diagnostic molecular markers for early OC screening are insufficient. The aim of this study was to identify potential relationship between the hypodontia and epithelial ovarian cancer (EOC).

Patients and methods: A retrospective study was conducted on 120 patients with EOC treated at the Department of Gynaecologic and Breast Oncology at the University Clinical Centre and 120 gynaecological healthy women (control group) of the same mean age. Women in both groups were reviewed for the presence of hypodontia and the patients with EOC also for clinicopathological characteristics of EOC according to hypodontia phenotype.

Results: Hypodontia was diagnosed in 23 (19.2%) of patients with EOC and 8 (6.7%) controls (p = 0.004; odds ratio [OR] = 3.32; confidence interval [CI], 1.42-7.76). There was no statistically significant difference in patients with EOC with or without hypodontia regarding histological subtype (p = 0.220); they differed in regard to FIGO stage (p = 0.014; OR =3.26; CI, 1.23-8.64) and tumour differentiation grade (p = 0.042; OR = 3.1; CI, 1.01-9.53). Also, bilateral occurrence of EOC was more common than unilateral occurrence in women with hypodontia (p = 0.021; OR = 2.9; CI, 1.15-7.36). We also found statistically significant difference between the ovarian cancer group and control group in presence of other malignant tumours in subjects (p < 0.001).

Conclusions: The results of the study suggest a statistical association between EOC and hypodontia phenotype. Hypodontia might serve as a risk factor for EOC detection.

No MeSH data available.


Related in: MedlinePlus

Hypodontia of both lower second premolars (persistent deciduous second molars).
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f1-rado-49-01-65: Hypodontia of both lower second premolars (persistent deciduous second molars).

Mentions: The prevalence of hypodontia in population varies quite a lot. Mattheeuws et al.16 reported prevalence of hypodontia in meta-analysis in the Caucasian population within 3.9–10.1%. Study by Fekonja29 showed 6.9% (7.8% in female and 5.9% in male) hypodontia prevalence in Maribor population (Slovenia). Results of our study show higher hypodontia prevalence in women with EOC, while the prevalence of control group was similar to Slovenian population.29 As hypodontia can be diagnosed early in the life (by radiographs as early as age nine), a possible association between hypodontia pheno-type and EOC could serve as the earliest possible quantifying risk factor for the EOC, before the development of clinical evident disease (Figure 1).


Hypodontia phenotype in patients with epithelial ovarian cancer.

Fekonja A, Cretnik A, Zerdoner D, Takac I - Radiol Oncol (2015)

Hypodontia of both lower second premolars (persistent deciduous second molars).
© Copyright Policy - open-access
Related In: Results  -  Collection

License 1 - License 2
Show All Figures
getmorefigures.php?uid=PMC4362608&req=5

f1-rado-49-01-65: Hypodontia of both lower second premolars (persistent deciduous second molars).
Mentions: The prevalence of hypodontia in population varies quite a lot. Mattheeuws et al.16 reported prevalence of hypodontia in meta-analysis in the Caucasian population within 3.9–10.1%. Study by Fekonja29 showed 6.9% (7.8% in female and 5.9% in male) hypodontia prevalence in Maribor population (Slovenia). Results of our study show higher hypodontia prevalence in women with EOC, while the prevalence of control group was similar to Slovenian population.29 As hypodontia can be diagnosed early in the life (by radiographs as early as age nine), a possible association between hypodontia pheno-type and EOC could serve as the earliest possible quantifying risk factor for the EOC, before the development of clinical evident disease (Figure 1).

Bottom Line: Ovarian cancer is usually diagnosed in an advanced stage and the present clinical and diagnostic molecular markers for early OC screening are insufficient.A retrospective study was conducted on 120 patients with EOC treated at the Department of Gynaecologic and Breast Oncology at the University Clinical Centre and 120 gynaecological healthy women (control group) of the same mean age.We also found statistically significant difference between the ovarian cancer group and control group in presence of other malignant tumours in subjects (p < 0.001).

View Article: PubMed Central - PubMed

Affiliation: Department of Orthodontics, Health Centre Maribor, Maribor, Slovenia.

ABSTRACT

Background: Ovarian cancer is usually diagnosed in an advanced stage and the present clinical and diagnostic molecular markers for early OC screening are insufficient. The aim of this study was to identify potential relationship between the hypodontia and epithelial ovarian cancer (EOC).

Patients and methods: A retrospective study was conducted on 120 patients with EOC treated at the Department of Gynaecologic and Breast Oncology at the University Clinical Centre and 120 gynaecological healthy women (control group) of the same mean age. Women in both groups were reviewed for the presence of hypodontia and the patients with EOC also for clinicopathological characteristics of EOC according to hypodontia phenotype.

Results: Hypodontia was diagnosed in 23 (19.2%) of patients with EOC and 8 (6.7%) controls (p = 0.004; odds ratio [OR] = 3.32; confidence interval [CI], 1.42-7.76). There was no statistically significant difference in patients with EOC with or without hypodontia regarding histological subtype (p = 0.220); they differed in regard to FIGO stage (p = 0.014; OR =3.26; CI, 1.23-8.64) and tumour differentiation grade (p = 0.042; OR = 3.1; CI, 1.01-9.53). Also, bilateral occurrence of EOC was more common than unilateral occurrence in women with hypodontia (p = 0.021; OR = 2.9; CI, 1.15-7.36). We also found statistically significant difference between the ovarian cancer group and control group in presence of other malignant tumours in subjects (p < 0.001).

Conclusions: The results of the study suggest a statistical association between EOC and hypodontia phenotype. Hypodontia might serve as a risk factor for EOC detection.

No MeSH data available.


Related in: MedlinePlus