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Clinical value of whole-body magnetic resonance imaging in health screening of general adult population.

Tarnoki DL, Tarnoki AD, Richter A, Karlinger K, Berczi V, Pickuth D - Radiol Oncol (2015)

Bottom Line: WB-MRA were negative in 16 subjects.Vascular normal variations were reported in 23%, and a 40% left proximal common carotid artery stenosis were described in one subject.Our study is the first which involved a highly selected patient group using a high field 3-T wide bore magnet system with T1, STIR, MRA and whole-body DWI acquisitions as well.

View Article: PubMed Central - PubMed

Affiliation: Department of Diagnostic and Interventional Radiology, Caritasklinikum Saarbrücken St. Theresia, Academic Teaching Hospital of Saarland University, Saarbrücken, Germany ; Department of Radiology and Oncotherapy, Semmelweis University School of Medicine, Budapest, Hungary.

ABSTRACT

Background: Whole-body magnetic resonance imaging (WB-MRI) and angiography (WB-MRA) has become increasingly popular in population-based research. We evaluated retrospectively the frequency of potentially relevant incidental findings throughout the body.

Materials and methods: 22 highly health-conscious managers (18 men, mean age 47±9 years) underwent WB-MRI and WB-MRA between March 2012 and September 2013 on a Discovery MR750w wide bore 3 Tesla device (GE Healthcare) using T1 weighted, short tau inversion recovery (STIR) and diffusion weighted imaging (DWI) acquisitions according to a standardized protocol.

Results: A suspicious (pararectal) malignancy was detected in one patient which was confirmed by an endorectal sonography. Incidental findings were described in 20 subjects, including hydrocele (11 patients), benign bony lesion (7 patients) and non-specific lymph nodes (5 patients). Further investigations were recommended in 68% (ultrasound: 36%, computed tomography: 28%, mammography: 9%, additional MRI: 9%). WB-MRA were negative in 16 subjects. Vascular normal variations were reported in 23%, and a 40% left proximal common carotid artery stenosis were described in one subject.

Conclusions: WB-MRI and MRA lead to the detection of clinically relevant diseases and unexpected findings in a cohort of healthy adults that require further imaging or surveillance in 68%. WB-MR imaging may play a paramount role in health screening, especially in the future generation of (epi)genetic based screening of malignant and atherosclerotic disorders. Our study is the first which involved a highly selected patient group using a high field 3-T wide bore magnet system with T1, STIR, MRA and whole-body DWI acquisitions as well.

No MeSH data available.


Related in: MedlinePlus

Whole-body MR image of a 52-year-old male patient with history of sleep disorder, night sweats, hypercholesterinaemia and previous smoking. Note the right pararectal 16×14 mm mass (arrows) on the coronal (A) T1 (hypointense signal) and (B) STIR images (hyperintense signal); (C) diffusion weighted (DWI) axial image indicating a restricted diffusion. Inverted DWI image is similar to a PET image.
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f4-rado-49-01-10: Whole-body MR image of a 52-year-old male patient with history of sleep disorder, night sweats, hypercholesterinaemia and previous smoking. Note the right pararectal 16×14 mm mass (arrows) on the coronal (A) T1 (hypointense signal) and (B) STIR images (hyperintense signal); (C) diffusion weighted (DWI) axial image indicating a restricted diffusion. Inverted DWI image is similar to a PET image.

Mentions: A suspicious (pararectal) malignancy was detected in one patient (Figure 4). Two patients had negative MR reports, whereas incidental findings were described in 20 subjects. The findings are shown in Figure 5. Hydrocele was the most common incidental finding (11 patients; 11 of 18 men), followed by a benign bony lesion in 7 patients. Incidental findings would have needed diagnostic workup at an urologist (17 lesions), rheumatologist (15 lesions), internist (13 lesions), otorhinolaryngologist (6 lesions), pulmonologist (6 lesions), surgeon (5 lesions), gynecologist (4 lesions), and dermatologist (1 lesion). Further investigations were recommended in 68% of subjects including eight sonographies (2/3 abdominal), five chest computed tomographies (CT), one pelvic CT, two mammographies and two additional MRIs. In case of the suspicious pararectal malignancy, biopsy was recommended. The patient had an endorectal sonography which confirmed the presence of a highly suspicious mass, probably a lymph node. A rectoscopy/colonoscopy was planned, however the patient moved to another city and the further diagnostic/therapeutic workup is unknown yet.


Clinical value of whole-body magnetic resonance imaging in health screening of general adult population.

Tarnoki DL, Tarnoki AD, Richter A, Karlinger K, Berczi V, Pickuth D - Radiol Oncol (2015)

Whole-body MR image of a 52-year-old male patient with history of sleep disorder, night sweats, hypercholesterinaemia and previous smoking. Note the right pararectal 16×14 mm mass (arrows) on the coronal (A) T1 (hypointense signal) and (B) STIR images (hyperintense signal); (C) diffusion weighted (DWI) axial image indicating a restricted diffusion. Inverted DWI image is similar to a PET image.
© Copyright Policy - open-access
Related In: Results  -  Collection

License 1 - License 2
Show All Figures
getmorefigures.php?uid=PMC4362601&req=5

f4-rado-49-01-10: Whole-body MR image of a 52-year-old male patient with history of sleep disorder, night sweats, hypercholesterinaemia and previous smoking. Note the right pararectal 16×14 mm mass (arrows) on the coronal (A) T1 (hypointense signal) and (B) STIR images (hyperintense signal); (C) diffusion weighted (DWI) axial image indicating a restricted diffusion. Inverted DWI image is similar to a PET image.
Mentions: A suspicious (pararectal) malignancy was detected in one patient (Figure 4). Two patients had negative MR reports, whereas incidental findings were described in 20 subjects. The findings are shown in Figure 5. Hydrocele was the most common incidental finding (11 patients; 11 of 18 men), followed by a benign bony lesion in 7 patients. Incidental findings would have needed diagnostic workup at an urologist (17 lesions), rheumatologist (15 lesions), internist (13 lesions), otorhinolaryngologist (6 lesions), pulmonologist (6 lesions), surgeon (5 lesions), gynecologist (4 lesions), and dermatologist (1 lesion). Further investigations were recommended in 68% of subjects including eight sonographies (2/3 abdominal), five chest computed tomographies (CT), one pelvic CT, two mammographies and two additional MRIs. In case of the suspicious pararectal malignancy, biopsy was recommended. The patient had an endorectal sonography which confirmed the presence of a highly suspicious mass, probably a lymph node. A rectoscopy/colonoscopy was planned, however the patient moved to another city and the further diagnostic/therapeutic workup is unknown yet.

Bottom Line: WB-MRA were negative in 16 subjects.Vascular normal variations were reported in 23%, and a 40% left proximal common carotid artery stenosis were described in one subject.Our study is the first which involved a highly selected patient group using a high field 3-T wide bore magnet system with T1, STIR, MRA and whole-body DWI acquisitions as well.

View Article: PubMed Central - PubMed

Affiliation: Department of Diagnostic and Interventional Radiology, Caritasklinikum Saarbrücken St. Theresia, Academic Teaching Hospital of Saarland University, Saarbrücken, Germany ; Department of Radiology and Oncotherapy, Semmelweis University School of Medicine, Budapest, Hungary.

ABSTRACT

Background: Whole-body magnetic resonance imaging (WB-MRI) and angiography (WB-MRA) has become increasingly popular in population-based research. We evaluated retrospectively the frequency of potentially relevant incidental findings throughout the body.

Materials and methods: 22 highly health-conscious managers (18 men, mean age 47±9 years) underwent WB-MRI and WB-MRA between March 2012 and September 2013 on a Discovery MR750w wide bore 3 Tesla device (GE Healthcare) using T1 weighted, short tau inversion recovery (STIR) and diffusion weighted imaging (DWI) acquisitions according to a standardized protocol.

Results: A suspicious (pararectal) malignancy was detected in one patient which was confirmed by an endorectal sonography. Incidental findings were described in 20 subjects, including hydrocele (11 patients), benign bony lesion (7 patients) and non-specific lymph nodes (5 patients). Further investigations were recommended in 68% (ultrasound: 36%, computed tomography: 28%, mammography: 9%, additional MRI: 9%). WB-MRA were negative in 16 subjects. Vascular normal variations were reported in 23%, and a 40% left proximal common carotid artery stenosis were described in one subject.

Conclusions: WB-MRI and MRA lead to the detection of clinically relevant diseases and unexpected findings in a cohort of healthy adults that require further imaging or surveillance in 68%. WB-MR imaging may play a paramount role in health screening, especially in the future generation of (epi)genetic based screening of malignant and atherosclerotic disorders. Our study is the first which involved a highly selected patient group using a high field 3-T wide bore magnet system with T1, STIR, MRA and whole-body DWI acquisitions as well.

No MeSH data available.


Related in: MedlinePlus