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Clinical value of whole-body magnetic resonance imaging in health screening of general adult population.

Tarnoki DL, Tarnoki AD, Richter A, Karlinger K, Berczi V, Pickuth D - Radiol Oncol (2015)

Bottom Line: WB-MRA were negative in 16 subjects.Vascular normal variations were reported in 23%, and a 40% left proximal common carotid artery stenosis were described in one subject.Our study is the first which involved a highly selected patient group using a high field 3-T wide bore magnet system with T1, STIR, MRA and whole-body DWI acquisitions as well.

View Article: PubMed Central - PubMed

Affiliation: Department of Diagnostic and Interventional Radiology, Caritasklinikum Saarbrücken St. Theresia, Academic Teaching Hospital of Saarland University, Saarbrücken, Germany ; Department of Radiology and Oncotherapy, Semmelweis University School of Medicine, Budapest, Hungary.

ABSTRACT

Background: Whole-body magnetic resonance imaging (WB-MRI) and angiography (WB-MRA) has become increasingly popular in population-based research. We evaluated retrospectively the frequency of potentially relevant incidental findings throughout the body.

Materials and methods: 22 highly health-conscious managers (18 men, mean age 47±9 years) underwent WB-MRI and WB-MRA between March 2012 and September 2013 on a Discovery MR750w wide bore 3 Tesla device (GE Healthcare) using T1 weighted, short tau inversion recovery (STIR) and diffusion weighted imaging (DWI) acquisitions according to a standardized protocol.

Results: A suspicious (pararectal) malignancy was detected in one patient which was confirmed by an endorectal sonography. Incidental findings were described in 20 subjects, including hydrocele (11 patients), benign bony lesion (7 patients) and non-specific lymph nodes (5 patients). Further investigations were recommended in 68% (ultrasound: 36%, computed tomography: 28%, mammography: 9%, additional MRI: 9%). WB-MRA were negative in 16 subjects. Vascular normal variations were reported in 23%, and a 40% left proximal common carotid artery stenosis were described in one subject.

Conclusions: WB-MRI and MRA lead to the detection of clinically relevant diseases and unexpected findings in a cohort of healthy adults that require further imaging or surveillance in 68%. WB-MR imaging may play a paramount role in health screening, especially in the future generation of (epi)genetic based screening of malignant and atherosclerotic disorders. Our study is the first which involved a highly selected patient group using a high field 3-T wide bore magnet system with T1, STIR, MRA and whole-body DWI acquisitions as well.

No MeSH data available.


Related in: MedlinePlus

Whole-body MRI set-up of coils (head, chest, abdomen and extremity coils) in a wide bore magnet device.
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f1-rado-49-01-10: Whole-body MRI set-up of coils (head, chest, abdomen and extremity coils) in a wide bore magnet device.

Mentions: We carried out a retrospective analysis of healthy adults (mainly managers, lawyers, accountants, chief executive officers, company directors) with extreme health consciousness who underwent whole-body MRI and MRA at the Institute of Diagnostic and Interventional Radiology, Caritasklinikum Saarbrücken St. Theresia, Germany between March 2012 and September 2013. Subjects were referred to WB-MRI scan by a family doctor, their company or were self referrals. The healthy adults completed a comprehensive questionnaire including their current symptoms, previous clinical findings, operations, and risk factors. MR studies were acquired on a Discovery MR750w 3 Tesla wide bore device (General Electric Healthcare, GE, Milwaukee, USA; 70 cm wide bore magnet) using T1 weighted (fast Spin Echo technique with a slice thickness of 5 mm), short tau inversion recovery (STIR), and DWI sequences according to a standardized protocol (Figure 1, 2). Depending upon the height of the patient, 6 or 7 slabs were acquired in a slab-by-slab-technique with no continuous table movement. The WB-MRI protocol was identical for all participants and included a plain WB-MRI and detailed examination of head, neck, chest, abdomen, pelvis, spine and extremities. A rolling platform with extended field of view allowed whole-body examinations with a table range of more than 200 cm, several dozen simultaneous receiver channels, and multiple plugs for attaching several RF coils concurrently enabling the individual to be covered with coils from “head to toe”. The high number of coils allowed for parallel imaging which speeded up the data acquisition.


Clinical value of whole-body magnetic resonance imaging in health screening of general adult population.

Tarnoki DL, Tarnoki AD, Richter A, Karlinger K, Berczi V, Pickuth D - Radiol Oncol (2015)

Whole-body MRI set-up of coils (head, chest, abdomen and extremity coils) in a wide bore magnet device.
© Copyright Policy - open-access
Related In: Results  -  Collection

License 1 - License 2
Show All Figures
getmorefigures.php?uid=PMC4362601&req=5

f1-rado-49-01-10: Whole-body MRI set-up of coils (head, chest, abdomen and extremity coils) in a wide bore magnet device.
Mentions: We carried out a retrospective analysis of healthy adults (mainly managers, lawyers, accountants, chief executive officers, company directors) with extreme health consciousness who underwent whole-body MRI and MRA at the Institute of Diagnostic and Interventional Radiology, Caritasklinikum Saarbrücken St. Theresia, Germany between March 2012 and September 2013. Subjects were referred to WB-MRI scan by a family doctor, their company or were self referrals. The healthy adults completed a comprehensive questionnaire including their current symptoms, previous clinical findings, operations, and risk factors. MR studies were acquired on a Discovery MR750w 3 Tesla wide bore device (General Electric Healthcare, GE, Milwaukee, USA; 70 cm wide bore magnet) using T1 weighted (fast Spin Echo technique with a slice thickness of 5 mm), short tau inversion recovery (STIR), and DWI sequences according to a standardized protocol (Figure 1, 2). Depending upon the height of the patient, 6 or 7 slabs were acquired in a slab-by-slab-technique with no continuous table movement. The WB-MRI protocol was identical for all participants and included a plain WB-MRI and detailed examination of head, neck, chest, abdomen, pelvis, spine and extremities. A rolling platform with extended field of view allowed whole-body examinations with a table range of more than 200 cm, several dozen simultaneous receiver channels, and multiple plugs for attaching several RF coils concurrently enabling the individual to be covered with coils from “head to toe”. The high number of coils allowed for parallel imaging which speeded up the data acquisition.

Bottom Line: WB-MRA were negative in 16 subjects.Vascular normal variations were reported in 23%, and a 40% left proximal common carotid artery stenosis were described in one subject.Our study is the first which involved a highly selected patient group using a high field 3-T wide bore magnet system with T1, STIR, MRA and whole-body DWI acquisitions as well.

View Article: PubMed Central - PubMed

Affiliation: Department of Diagnostic and Interventional Radiology, Caritasklinikum Saarbrücken St. Theresia, Academic Teaching Hospital of Saarland University, Saarbrücken, Germany ; Department of Radiology and Oncotherapy, Semmelweis University School of Medicine, Budapest, Hungary.

ABSTRACT

Background: Whole-body magnetic resonance imaging (WB-MRI) and angiography (WB-MRA) has become increasingly popular in population-based research. We evaluated retrospectively the frequency of potentially relevant incidental findings throughout the body.

Materials and methods: 22 highly health-conscious managers (18 men, mean age 47±9 years) underwent WB-MRI and WB-MRA between March 2012 and September 2013 on a Discovery MR750w wide bore 3 Tesla device (GE Healthcare) using T1 weighted, short tau inversion recovery (STIR) and diffusion weighted imaging (DWI) acquisitions according to a standardized protocol.

Results: A suspicious (pararectal) malignancy was detected in one patient which was confirmed by an endorectal sonography. Incidental findings were described in 20 subjects, including hydrocele (11 patients), benign bony lesion (7 patients) and non-specific lymph nodes (5 patients). Further investigations were recommended in 68% (ultrasound: 36%, computed tomography: 28%, mammography: 9%, additional MRI: 9%). WB-MRA were negative in 16 subjects. Vascular normal variations were reported in 23%, and a 40% left proximal common carotid artery stenosis were described in one subject.

Conclusions: WB-MRI and MRA lead to the detection of clinically relevant diseases and unexpected findings in a cohort of healthy adults that require further imaging or surveillance in 68%. WB-MR imaging may play a paramount role in health screening, especially in the future generation of (epi)genetic based screening of malignant and atherosclerotic disorders. Our study is the first which involved a highly selected patient group using a high field 3-T wide bore magnet system with T1, STIR, MRA and whole-body DWI acquisitions as well.

No MeSH data available.


Related in: MedlinePlus