Centrin2 regulates CP110 removal in primary cilium formation.
Bottom Line: Cellular quiescence potentiates ciliogenesis, but the regulation of basal body formation is not fully understood.Knockdown of CP110 rescued ciliation in CETN2-deficient cells.Thus, centrin2 regulates primary ciliogenesis through controlling CP110 levels.
Affiliation: Centre for Chromosome Biology, School of Natural Sciences, National University of Ireland, Galway, Galway, Ireland.Show MeSH
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Mentions: TEM confirmed the integrity of the centrioles in centrin2-deficient cells (Fig. 4 a). This analysis also demonstrated that centrioles docked successfully with ciliary vesicles, a key early step in ciliogenesis that is directed by Cep164 (Fig. 4 a; Sorokin, 1962; Schmidt et al., 2012; Tanos et al., 2013). Despite the abnormal Cep164 distribution that we saw in centrin-deficient cells, this observation indicates that the distal appendages are capable of allowing docking and that the defect in ciliation lies at a later stage in the process.
Affiliation: Centre for Chromosome Biology, School of Natural Sciences, National University of Ireland, Galway, Galway, Ireland.