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Structural brain abnormalities in postural tachycardia syndrome: A VBM-DARTEL study.

Umeda S, Harrison NA, Gray MA, Mathias CJ, Critchley HD - Front Neurosci (2015)

Bottom Line: In the present study, we used magnetic resonance imaging (MRI) with voxel-based morphometry (VBM) applying the diffeomorphic anatomical registration through exponentiated lie algebra (DARTEL) procedure to examine variation in regional brain structure associated with PoTS.We also observed lower white matter volume beneath the precentral gyrus and paracentral lobule, right pre- and post-central gyrus, paracentral lobule and superior frontal gyrus in PoTS patients.Subsequent ROI analyses revealed significant negative correlations between left insula volume and trait anxiety and depression scores.

View Article: PubMed Central - PubMed

Affiliation: Department of Psychology, Keio University Tokyo, Japan ; Autonomic Unit, National Hospital for Neurology and Neurosurgery, University College London London, UK.

ABSTRACT
Postural tachycardia syndrome (PoTS), a form of dysautonomia, is characterized by orthostatic intolerance, and is frequently accompanied by a range of symptoms including palpitations, lightheadedness, clouding of thought, blurred vision, fatigue, anxiety, and depression. Although the estimated prevalence of PoTS is approximately 5-10 times as common as the better-known condition orthostatic hypotension, the neural substrates of the syndrome are poorly characterized. In the present study, we used magnetic resonance imaging (MRI) with voxel-based morphometry (VBM) applying the diffeomorphic anatomical registration through exponentiated lie algebra (DARTEL) procedure to examine variation in regional brain structure associated with PoTS. We recruited 11 patients with established PoTS and 23 age-matched normal controls. Group comparison of gray matter volume revealed diminished gray matter volume within the left anterior insula, right middle frontal gyrus and right cingulate gyrus in the PoTS group. We also observed lower white matter volume beneath the precentral gyrus and paracentral lobule, right pre- and post-central gyrus, paracentral lobule and superior frontal gyrus in PoTS patients. Subsequent ROI analyses revealed significant negative correlations between left insula volume and trait anxiety and depression scores. Together, these findings of structural differences, particularly within insular and cingulate components of the salience network, suggest a link between dysregulated physiological reactions arising from compromised central autonomic control (and interoceptive representation) and increased vulnerability to psychiatric symptoms in PoTS patients.

No MeSH data available.


Related in: MedlinePlus

Significant negative correlation between regional gray matter volume in the left insula and the scores of the STAI (trait anxiety) questionnaire.
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Figure 3: Significant negative correlation between regional gray matter volume in the left insula and the scores of the STAI (trait anxiety) questionnaire.

Mentions: In order to quantify the correlation between personality traits and the degree of reduction in left insula (the area with the most significant gray matter volume reduction), we extracted the contrast estimate values from the ROI of left insula, reflecting tissue volume, in all participants (n = 23). Interestingly, this revealed a significant negative correlation between left insula volume and both trait anxiety (STAI r = −0.463, t(21) = 2.39, p < 0.05) (Figure 3) and depression score (BDI-II r = −0.418, t(21) = 2.11, p < 0.05) (Figure 4).


Structural brain abnormalities in postural tachycardia syndrome: A VBM-DARTEL study.

Umeda S, Harrison NA, Gray MA, Mathias CJ, Critchley HD - Front Neurosci (2015)

Significant negative correlation between regional gray matter volume in the left insula and the scores of the STAI (trait anxiety) questionnaire.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4362313&req=5

Figure 3: Significant negative correlation between regional gray matter volume in the left insula and the scores of the STAI (trait anxiety) questionnaire.
Mentions: In order to quantify the correlation between personality traits and the degree of reduction in left insula (the area with the most significant gray matter volume reduction), we extracted the contrast estimate values from the ROI of left insula, reflecting tissue volume, in all participants (n = 23). Interestingly, this revealed a significant negative correlation between left insula volume and both trait anxiety (STAI r = −0.463, t(21) = 2.39, p < 0.05) (Figure 3) and depression score (BDI-II r = −0.418, t(21) = 2.11, p < 0.05) (Figure 4).

Bottom Line: In the present study, we used magnetic resonance imaging (MRI) with voxel-based morphometry (VBM) applying the diffeomorphic anatomical registration through exponentiated lie algebra (DARTEL) procedure to examine variation in regional brain structure associated with PoTS.We also observed lower white matter volume beneath the precentral gyrus and paracentral lobule, right pre- and post-central gyrus, paracentral lobule and superior frontal gyrus in PoTS patients.Subsequent ROI analyses revealed significant negative correlations between left insula volume and trait anxiety and depression scores.

View Article: PubMed Central - PubMed

Affiliation: Department of Psychology, Keio University Tokyo, Japan ; Autonomic Unit, National Hospital for Neurology and Neurosurgery, University College London London, UK.

ABSTRACT
Postural tachycardia syndrome (PoTS), a form of dysautonomia, is characterized by orthostatic intolerance, and is frequently accompanied by a range of symptoms including palpitations, lightheadedness, clouding of thought, blurred vision, fatigue, anxiety, and depression. Although the estimated prevalence of PoTS is approximately 5-10 times as common as the better-known condition orthostatic hypotension, the neural substrates of the syndrome are poorly characterized. In the present study, we used magnetic resonance imaging (MRI) with voxel-based morphometry (VBM) applying the diffeomorphic anatomical registration through exponentiated lie algebra (DARTEL) procedure to examine variation in regional brain structure associated with PoTS. We recruited 11 patients with established PoTS and 23 age-matched normal controls. Group comparison of gray matter volume revealed diminished gray matter volume within the left anterior insula, right middle frontal gyrus and right cingulate gyrus in the PoTS group. We also observed lower white matter volume beneath the precentral gyrus and paracentral lobule, right pre- and post-central gyrus, paracentral lobule and superior frontal gyrus in PoTS patients. Subsequent ROI analyses revealed significant negative correlations between left insula volume and trait anxiety and depression scores. Together, these findings of structural differences, particularly within insular and cingulate components of the salience network, suggest a link between dysregulated physiological reactions arising from compromised central autonomic control (and interoceptive representation) and increased vulnerability to psychiatric symptoms in PoTS patients.

No MeSH data available.


Related in: MedlinePlus