Limits...
Structural brain abnormalities in postural tachycardia syndrome: A VBM-DARTEL study.

Umeda S, Harrison NA, Gray MA, Mathias CJ, Critchley HD - Front Neurosci (2015)

Bottom Line: In the present study, we used magnetic resonance imaging (MRI) with voxel-based morphometry (VBM) applying the diffeomorphic anatomical registration through exponentiated lie algebra (DARTEL) procedure to examine variation in regional brain structure associated with PoTS.We also observed lower white matter volume beneath the precentral gyrus and paracentral lobule, right pre- and post-central gyrus, paracentral lobule and superior frontal gyrus in PoTS patients.Subsequent ROI analyses revealed significant negative correlations between left insula volume and trait anxiety and depression scores.

View Article: PubMed Central - PubMed

Affiliation: Department of Psychology, Keio University Tokyo, Japan ; Autonomic Unit, National Hospital for Neurology and Neurosurgery, University College London London, UK.

ABSTRACT
Postural tachycardia syndrome (PoTS), a form of dysautonomia, is characterized by orthostatic intolerance, and is frequently accompanied by a range of symptoms including palpitations, lightheadedness, clouding of thought, blurred vision, fatigue, anxiety, and depression. Although the estimated prevalence of PoTS is approximately 5-10 times as common as the better-known condition orthostatic hypotension, the neural substrates of the syndrome are poorly characterized. In the present study, we used magnetic resonance imaging (MRI) with voxel-based morphometry (VBM) applying the diffeomorphic anatomical registration through exponentiated lie algebra (DARTEL) procedure to examine variation in regional brain structure associated with PoTS. We recruited 11 patients with established PoTS and 23 age-matched normal controls. Group comparison of gray matter volume revealed diminished gray matter volume within the left anterior insula, right middle frontal gyrus and right cingulate gyrus in the PoTS group. We also observed lower white matter volume beneath the precentral gyrus and paracentral lobule, right pre- and post-central gyrus, paracentral lobule and superior frontal gyrus in PoTS patients. Subsequent ROI analyses revealed significant negative correlations between left insula volume and trait anxiety and depression scores. Together, these findings of structural differences, particularly within insular and cingulate components of the salience network, suggest a link between dysregulated physiological reactions arising from compromised central autonomic control (and interoceptive representation) and increased vulnerability to psychiatric symptoms in PoTS patients.

No MeSH data available.


Related in: MedlinePlus

Brain areas with significant volume reduction of white matter (WM). Green map: Control vs. PoTS, Red map: PoTS vs. Control. From left panel (−50): left middle temporal gyrus, (−34): left paracentral lobule, (−28): right postcentral gyrus, (−18): left precentral gyrus.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
getmorefigures.php?uid=PMC4362313&req=5

Figure 2: Brain areas with significant volume reduction of white matter (WM). Green map: Control vs. PoTS, Red map: PoTS vs. Control. From left panel (−50): left middle temporal gyrus, (−34): left paracentral lobule, (−28): right postcentral gyrus, (−18): left precentral gyrus.

Mentions: Our analysis additionally revealed lower WM volume within regions adjacent to precentral gyrus, paracentral lobule, right pre- and post-central gyrus, paracentral lobule and superior frontal gyrus (Figure 2 green map, uncorrected p < 0.001). In contrast, PoTS patients showed an increase in white matter volume in the left middle temporal gyrus (Figure 2 red map, uncorrected p < 0.001). Of note all findings are reported after controlling for age, gender and total intracranial volume (Table 1).


Structural brain abnormalities in postural tachycardia syndrome: A VBM-DARTEL study.

Umeda S, Harrison NA, Gray MA, Mathias CJ, Critchley HD - Front Neurosci (2015)

Brain areas with significant volume reduction of white matter (WM). Green map: Control vs. PoTS, Red map: PoTS vs. Control. From left panel (−50): left middle temporal gyrus, (−34): left paracentral lobule, (−28): right postcentral gyrus, (−18): left precentral gyrus.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4362313&req=5

Figure 2: Brain areas with significant volume reduction of white matter (WM). Green map: Control vs. PoTS, Red map: PoTS vs. Control. From left panel (−50): left middle temporal gyrus, (−34): left paracentral lobule, (−28): right postcentral gyrus, (−18): left precentral gyrus.
Mentions: Our analysis additionally revealed lower WM volume within regions adjacent to precentral gyrus, paracentral lobule, right pre- and post-central gyrus, paracentral lobule and superior frontal gyrus (Figure 2 green map, uncorrected p < 0.001). In contrast, PoTS patients showed an increase in white matter volume in the left middle temporal gyrus (Figure 2 red map, uncorrected p < 0.001). Of note all findings are reported after controlling for age, gender and total intracranial volume (Table 1).

Bottom Line: In the present study, we used magnetic resonance imaging (MRI) with voxel-based morphometry (VBM) applying the diffeomorphic anatomical registration through exponentiated lie algebra (DARTEL) procedure to examine variation in regional brain structure associated with PoTS.We also observed lower white matter volume beneath the precentral gyrus and paracentral lobule, right pre- and post-central gyrus, paracentral lobule and superior frontal gyrus in PoTS patients.Subsequent ROI analyses revealed significant negative correlations between left insula volume and trait anxiety and depression scores.

View Article: PubMed Central - PubMed

Affiliation: Department of Psychology, Keio University Tokyo, Japan ; Autonomic Unit, National Hospital for Neurology and Neurosurgery, University College London London, UK.

ABSTRACT
Postural tachycardia syndrome (PoTS), a form of dysautonomia, is characterized by orthostatic intolerance, and is frequently accompanied by a range of symptoms including palpitations, lightheadedness, clouding of thought, blurred vision, fatigue, anxiety, and depression. Although the estimated prevalence of PoTS is approximately 5-10 times as common as the better-known condition orthostatic hypotension, the neural substrates of the syndrome are poorly characterized. In the present study, we used magnetic resonance imaging (MRI) with voxel-based morphometry (VBM) applying the diffeomorphic anatomical registration through exponentiated lie algebra (DARTEL) procedure to examine variation in regional brain structure associated with PoTS. We recruited 11 patients with established PoTS and 23 age-matched normal controls. Group comparison of gray matter volume revealed diminished gray matter volume within the left anterior insula, right middle frontal gyrus and right cingulate gyrus in the PoTS group. We also observed lower white matter volume beneath the precentral gyrus and paracentral lobule, right pre- and post-central gyrus, paracentral lobule and superior frontal gyrus in PoTS patients. Subsequent ROI analyses revealed significant negative correlations between left insula volume and trait anxiety and depression scores. Together, these findings of structural differences, particularly within insular and cingulate components of the salience network, suggest a link between dysregulated physiological reactions arising from compromised central autonomic control (and interoceptive representation) and increased vulnerability to psychiatric symptoms in PoTS patients.

No MeSH data available.


Related in: MedlinePlus