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The effect of listening to music on human transcriptome.

Kanduri C, Raijas P, Ahvenainen M, Philips AK, Ukkola-Vuoti L, Lähdesmäki H, Järvelä I - PeerJ (2015)

Bottom Line: With the advent of genomics and bioinformatics approaches, these effects of music can now be studied in a more detailed fashion.One of the most up-regulated genes, alpha-synuclein (SNCA), is located in the best linkage region of musical aptitude on chromosome 4q22.1 and is regulated by GATA2, which is known to be associated with musical aptitude.We observed no significant findings in musically inexperienced participants.

View Article: PubMed Central - HTML - PubMed

Affiliation: Department of Medical Genetics, University of Helsinki , Finland.

ABSTRACT
Although brain imaging studies have demonstrated that listening to music alters human brain structure and function, the molecular mechanisms mediating those effects remain unknown. With the advent of genomics and bioinformatics approaches, these effects of music can now be studied in a more detailed fashion. To verify whether listening to classical music has any effect on human transcriptome, we performed genome-wide transcriptional profiling from the peripheral blood of participants after listening to classical music (n = 48), and after a control study without music exposure (n = 15). As musical experience is known to influence the responses to music, we compared the transcriptional responses of musically experienced and inexperienced participants separately with those of the controls. Comparisons were made based on two subphenotypes of musical experience: musical aptitude and music education. In musically experiencd participants, we observed the differential expression of 45 genes (27 up- and 18 down-regulated) and 97 genes (75 up- and 22 down-regulated) respectively based on subphenotype comparisons (rank product non-parametric statistics, pfp 0.05, >1.2-fold change over time across conditions). Gene ontological overrepresentation analysis (hypergeometric test, FDR < 0.05) revealed that the up-regulated genes are primarily known to be involved in the secretion and transport of dopamine, neuron projection, protein sumoylation, long-term potentiation and dephosphorylation. Down-regulated genes are known to be involved in ATP synthase-coupled proton transport, cytolysis, and positive regulation of caspase, peptidase and endopeptidase activities. One of the most up-regulated genes, alpha-synuclein (SNCA), is located in the best linkage region of musical aptitude on chromosome 4q22.1 and is regulated by GATA2, which is known to be associated with musical aptitude. Several genes reported to regulate song perception and production in songbirds displayed altered activities, suggesting a possible evolutionary conservation of sound perception between species. We observed no significant findings in musically inexperienced participants.

No MeSH data available.


Related in: MedlinePlus

Differential gene expression in experienced listeners vs ‘music-free’ controls.Heatplot representations of mean expression values pre- and post-music listening session and control sessions. The red-yellow-green palette represents low-moderate-high expression values. (A) Educated listeners vs controls, (B) Competent listeners vs controls.
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fig-1: Differential gene expression in experienced listeners vs ‘music-free’ controls.Heatplot representations of mean expression values pre- and post-music listening session and control sessions. The red-yellow-green palette represents low-moderate-high expression values. (A) Educated listeners vs controls, (B) Competent listeners vs controls.

Mentions: First, we compared the magnitude of pre-post fold-changes in the genome-wide transcriptional profiles of listeners of edu classes 3–4 (n = 29) and controls (n = 10). Using RankProd non-parametric statistics and stringent selection criteria, we identified 45 differentially expressed genes (27 up-regulated and 18 down-regulated). Next, we compared the genome-wide transcriptional profiles of listeners with high COMB scores (n = 12) and controls (n = 10). Similar statistical analysis identified 97 differentially expressed genes (75 up-regulated and 22 down-regulated). The differentially expressed genes from both the comparisons are listed in Table S2, and a comparison of the pre-post changes in both conditions is shown in Fig. 1.


The effect of listening to music on human transcriptome.

Kanduri C, Raijas P, Ahvenainen M, Philips AK, Ukkola-Vuoti L, Lähdesmäki H, Järvelä I - PeerJ (2015)

Differential gene expression in experienced listeners vs ‘music-free’ controls.Heatplot representations of mean expression values pre- and post-music listening session and control sessions. The red-yellow-green palette represents low-moderate-high expression values. (A) Educated listeners vs controls, (B) Competent listeners vs controls.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4362302&req=5

fig-1: Differential gene expression in experienced listeners vs ‘music-free’ controls.Heatplot representations of mean expression values pre- and post-music listening session and control sessions. The red-yellow-green palette represents low-moderate-high expression values. (A) Educated listeners vs controls, (B) Competent listeners vs controls.
Mentions: First, we compared the magnitude of pre-post fold-changes in the genome-wide transcriptional profiles of listeners of edu classes 3–4 (n = 29) and controls (n = 10). Using RankProd non-parametric statistics and stringent selection criteria, we identified 45 differentially expressed genes (27 up-regulated and 18 down-regulated). Next, we compared the genome-wide transcriptional profiles of listeners with high COMB scores (n = 12) and controls (n = 10). Similar statistical analysis identified 97 differentially expressed genes (75 up-regulated and 22 down-regulated). The differentially expressed genes from both the comparisons are listed in Table S2, and a comparison of the pre-post changes in both conditions is shown in Fig. 1.

Bottom Line: With the advent of genomics and bioinformatics approaches, these effects of music can now be studied in a more detailed fashion.One of the most up-regulated genes, alpha-synuclein (SNCA), is located in the best linkage region of musical aptitude on chromosome 4q22.1 and is regulated by GATA2, which is known to be associated with musical aptitude.We observed no significant findings in musically inexperienced participants.

View Article: PubMed Central - HTML - PubMed

Affiliation: Department of Medical Genetics, University of Helsinki , Finland.

ABSTRACT
Although brain imaging studies have demonstrated that listening to music alters human brain structure and function, the molecular mechanisms mediating those effects remain unknown. With the advent of genomics and bioinformatics approaches, these effects of music can now be studied in a more detailed fashion. To verify whether listening to classical music has any effect on human transcriptome, we performed genome-wide transcriptional profiling from the peripheral blood of participants after listening to classical music (n = 48), and after a control study without music exposure (n = 15). As musical experience is known to influence the responses to music, we compared the transcriptional responses of musically experienced and inexperienced participants separately with those of the controls. Comparisons were made based on two subphenotypes of musical experience: musical aptitude and music education. In musically experiencd participants, we observed the differential expression of 45 genes (27 up- and 18 down-regulated) and 97 genes (75 up- and 22 down-regulated) respectively based on subphenotype comparisons (rank product non-parametric statistics, pfp 0.05, >1.2-fold change over time across conditions). Gene ontological overrepresentation analysis (hypergeometric test, FDR < 0.05) revealed that the up-regulated genes are primarily known to be involved in the secretion and transport of dopamine, neuron projection, protein sumoylation, long-term potentiation and dephosphorylation. Down-regulated genes are known to be involved in ATP synthase-coupled proton transport, cytolysis, and positive regulation of caspase, peptidase and endopeptidase activities. One of the most up-regulated genes, alpha-synuclein (SNCA), is located in the best linkage region of musical aptitude on chromosome 4q22.1 and is regulated by GATA2, which is known to be associated with musical aptitude. Several genes reported to regulate song perception and production in songbirds displayed altered activities, suggesting a possible evolutionary conservation of sound perception between species. We observed no significant findings in musically inexperienced participants.

No MeSH data available.


Related in: MedlinePlus