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Modern reproductive patterns associated with estrogen receptor positive but not negative breast cancer susceptibility.

Aktipis CA, Ellis BJ, Nishimura KK, Hiatt RA - Evol Med Public Health (2014)

Bottom Line: We conducted a meta-analysis to assess whether this 'evolutionary mismatch hypothesis' can explain susceptibility to both estrogen receptor positive (ER-positive) and estrogen receptor negative (ER-negative) cancer.Our meta-analysis includes a total of 33 studies and examines parity, age of first birth and age of menarche broken down by estrogen receptor status.We found that modern reproductive patterns are more closely linked to ER-positive than ER-negative breast cancer.

View Article: PubMed Central - PubMed

Affiliation: Center for Evolution and Cancer, University of California San Francisco, 2340 Sutter Street S-341, Box 0128, San Francisco, CA 94143-0128, USA; Department of Psychology, Arizona State University, PO Box 871104, Tempe, AZ 85287-1104, USA; Norton School of Family and Consumer Sciences, University of Arizona, 650 N Park Ave, Tucson, AZ 85721, USA; Department of Epidemiology and Biostatistics, University of California San Francisco, Box 0560, UCSF, San Francisco, CA 94143, USA Center for Evolution and Cancer, University of California San Francisco, 2340 Sutter Street S-341, Box 0128, San Francisco, CA 94143-0128, USA; Department of Psychology, Arizona State University, PO Box 871104, Tempe, AZ 85287-1104, USA; Norton School of Family and Consumer Sciences, University of Arizona, 650 N Park Ave, Tucson, AZ 85721, USA; Department of Epidemiology and Biostatistics, University of California San Francisco, Box 0560, UCSF, San Francisco, CA 94143, USA aktipis@asu.edu.

No MeSH data available.


Related in: MedlinePlus

(a) Parity is associated with a lower risk of ER-positive breast cancer. (b) Parity is not associated with risk of ER-negative breast cancer. OR was calculated using a random effects model to account for heterogeneity of study populations. The red squares and horizontal black lines represent the ORs and 95% CIs for each study. The black diamond and its width represent the overall effect estimate and the 95% CI. The vertical black line represents the  hypothesis (OR of 1). Premeno. = pre-menopausal, Postmeno. = post-menopausal, ER = estrogen receptor, PR = progesterone receptor, TN = triple negative, HER2 = human epidermal growth factor receptor 2, Lum. = luminal
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eou028-F1: (a) Parity is associated with a lower risk of ER-positive breast cancer. (b) Parity is not associated with risk of ER-negative breast cancer. OR was calculated using a random effects model to account for heterogeneity of study populations. The red squares and horizontal black lines represent the ORs and 95% CIs for each study. The black diamond and its width represent the overall effect estimate and the 95% CI. The vertical black line represents the hypothesis (OR of 1). Premeno. = pre-menopausal, Postmeno. = post-menopausal, ER = estrogen receptor, PR = progesterone receptor, TN = triple negative, HER2 = human epidermal growth factor receptor 2, Lum. = luminal

Mentions: Parity was found to be protective against ER-positive breast cancer (Fig. 1a; odds ratio (OR) = 0.77, 95% confidence interval (CI) = 0.71–0.82, P < 0.001) but not protective against ER-negative breast cancer (Fig. 1b; OR = 1.01, 95% CI = 0.95–1.08, P = 0.69). In other words, our meta-analysis showed that women who had given birth to one or more children had a lower risk of ER-positive breast cancer but that their risk of ER-negative breast cancer was not affected.Figure 1.


Modern reproductive patterns associated with estrogen receptor positive but not negative breast cancer susceptibility.

Aktipis CA, Ellis BJ, Nishimura KK, Hiatt RA - Evol Med Public Health (2014)

(a) Parity is associated with a lower risk of ER-positive breast cancer. (b) Parity is not associated with risk of ER-negative breast cancer. OR was calculated using a random effects model to account for heterogeneity of study populations. The red squares and horizontal black lines represent the ORs and 95% CIs for each study. The black diamond and its width represent the overall effect estimate and the 95% CI. The vertical black line represents the  hypothesis (OR of 1). Premeno. = pre-menopausal, Postmeno. = post-menopausal, ER = estrogen receptor, PR = progesterone receptor, TN = triple negative, HER2 = human epidermal growth factor receptor 2, Lum. = luminal
© Copyright Policy - creative-commons
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4362290&req=5

eou028-F1: (a) Parity is associated with a lower risk of ER-positive breast cancer. (b) Parity is not associated with risk of ER-negative breast cancer. OR was calculated using a random effects model to account for heterogeneity of study populations. The red squares and horizontal black lines represent the ORs and 95% CIs for each study. The black diamond and its width represent the overall effect estimate and the 95% CI. The vertical black line represents the hypothesis (OR of 1). Premeno. = pre-menopausal, Postmeno. = post-menopausal, ER = estrogen receptor, PR = progesterone receptor, TN = triple negative, HER2 = human epidermal growth factor receptor 2, Lum. = luminal
Mentions: Parity was found to be protective against ER-positive breast cancer (Fig. 1a; odds ratio (OR) = 0.77, 95% confidence interval (CI) = 0.71–0.82, P < 0.001) but not protective against ER-negative breast cancer (Fig. 1b; OR = 1.01, 95% CI = 0.95–1.08, P = 0.69). In other words, our meta-analysis showed that women who had given birth to one or more children had a lower risk of ER-positive breast cancer but that their risk of ER-negative breast cancer was not affected.Figure 1.

Bottom Line: We conducted a meta-analysis to assess whether this 'evolutionary mismatch hypothesis' can explain susceptibility to both estrogen receptor positive (ER-positive) and estrogen receptor negative (ER-negative) cancer.Our meta-analysis includes a total of 33 studies and examines parity, age of first birth and age of menarche broken down by estrogen receptor status.We found that modern reproductive patterns are more closely linked to ER-positive than ER-negative breast cancer.

View Article: PubMed Central - PubMed

Affiliation: Center for Evolution and Cancer, University of California San Francisco, 2340 Sutter Street S-341, Box 0128, San Francisco, CA 94143-0128, USA; Department of Psychology, Arizona State University, PO Box 871104, Tempe, AZ 85287-1104, USA; Norton School of Family and Consumer Sciences, University of Arizona, 650 N Park Ave, Tucson, AZ 85721, USA; Department of Epidemiology and Biostatistics, University of California San Francisco, Box 0560, UCSF, San Francisco, CA 94143, USA Center for Evolution and Cancer, University of California San Francisco, 2340 Sutter Street S-341, Box 0128, San Francisco, CA 94143-0128, USA; Department of Psychology, Arizona State University, PO Box 871104, Tempe, AZ 85287-1104, USA; Norton School of Family and Consumer Sciences, University of Arizona, 650 N Park Ave, Tucson, AZ 85721, USA; Department of Epidemiology and Biostatistics, University of California San Francisco, Box 0560, UCSF, San Francisco, CA 94143, USA aktipis@asu.edu.

No MeSH data available.


Related in: MedlinePlus