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Protective effect of hydroalcoholic extract of tribulus terrestris on Cisplatin induced renal tissue damage in male mice.

Raoofi A, Khazaei M, Ghanbari A - Int J Prev Med (2015)

Bottom Line: The kidneys were removed after 4 days of injections, and histological evaluations were performed.The data were analyzed using one-way analysis of variance followed by Tukey's post-hoc test, paired-sample t-test, Kruskal-Wallis and Mann-Whitney tests.These parameters reached to the normal range after administration of fruit extracts of TT for 4 days.

View Article: PubMed Central - PubMed

Affiliation: Fertility and Infertility Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran.

ABSTRACT

Background: According beneficial effects of Tribulus terrestris (TT) extract on tissue damage, the present study investigated the influence of hydroalcoholic extract of TT plant on cisplatin (CIS) (EBEWE Pharma, Unterach, Austria) induced renal tissue damage in male mice.

Methods: Thirty mice were divided into five groups (n = 6). The first group (control) was treated with normal saline (0.9% NaCl) and experimental groups with CIS (E1), CIS + 100 mg/kg extract of TT (E2), CIS + 300 mg/kg extract of TT (E3), CIS + 500 mg/kg extract of TT (E4) intraperitoneally. The kidneys were removed after 4 days of injections, and histological evaluations were performed.

Results: The data were analyzed using one-way analysis of variance followed by Tukey's post-hoc test, paired-sample t-test, Kruskal-Wallis and Mann-Whitney tests. In the CIS treated group, the whole kidney tissue showed an increased dilatation of Bowman's capsule, medullar congestion, and dilatation of collecting tubules and a decreased in the body weight and kidney weight. These parameters reached to the normal range after administration of fruit extracts of TT for 4 days.

Conclusions: The results suggested that the oral administration of TT fruit extract at dose 100, 300 and 500 mg/kg body weight provided protection against the CIS induced toxicity in the mice.

No MeSH data available.


Related in: MedlinePlus

The effect of toxic dose of cisplatin (CIS) (5.5 mg/kg) and different doses of TT on total body weights in the mice (left bar of the pairs is initial weights and the right bar is end weights). The groups (X axis) are control: not treated, E1: CIS, E2: CIS + Tribulus Terrestris (TT) (100 mg/kg), E3: CIS + TT (300 mg/kg), E4: CIS + TT (500 mg/kg). (*P < 0.05, **P < 0.01)
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Figure 1: The effect of toxic dose of cisplatin (CIS) (5.5 mg/kg) and different doses of TT on total body weights in the mice (left bar of the pairs is initial weights and the right bar is end weights). The groups (X axis) are control: not treated, E1: CIS, E2: CIS + Tribulus Terrestris (TT) (100 mg/kg), E3: CIS + TT (300 mg/kg), E4: CIS + TT (500 mg/kg). (*P < 0.05, **P < 0.01)

Mentions: The data showed that there were no significant differences in the body weight before and after the experiments in control, E3, and E4 groups (P > 0.05) [Figure 1]. While the body weight was reduced at the end of the experiments in CIS (E1) (P = 0.004) and CIS + 100 mg/kg extract of TT groups (E2) (P = 0.011). The weight of the kidneys in comparison with control group were significantly decreased in E1 (P = 0.002) group but there was not changed in other ones (P > 0.05) [Table 1 and Figure 2].


Protective effect of hydroalcoholic extract of tribulus terrestris on Cisplatin induced renal tissue damage in male mice.

Raoofi A, Khazaei M, Ghanbari A - Int J Prev Med (2015)

The effect of toxic dose of cisplatin (CIS) (5.5 mg/kg) and different doses of TT on total body weights in the mice (left bar of the pairs is initial weights and the right bar is end weights). The groups (X axis) are control: not treated, E1: CIS, E2: CIS + Tribulus Terrestris (TT) (100 mg/kg), E3: CIS + TT (300 mg/kg), E4: CIS + TT (500 mg/kg). (*P < 0.05, **P < 0.01)
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4362283&req=5

Figure 1: The effect of toxic dose of cisplatin (CIS) (5.5 mg/kg) and different doses of TT on total body weights in the mice (left bar of the pairs is initial weights and the right bar is end weights). The groups (X axis) are control: not treated, E1: CIS, E2: CIS + Tribulus Terrestris (TT) (100 mg/kg), E3: CIS + TT (300 mg/kg), E4: CIS + TT (500 mg/kg). (*P < 0.05, **P < 0.01)
Mentions: The data showed that there were no significant differences in the body weight before and after the experiments in control, E3, and E4 groups (P > 0.05) [Figure 1]. While the body weight was reduced at the end of the experiments in CIS (E1) (P = 0.004) and CIS + 100 mg/kg extract of TT groups (E2) (P = 0.011). The weight of the kidneys in comparison with control group were significantly decreased in E1 (P = 0.002) group but there was not changed in other ones (P > 0.05) [Table 1 and Figure 2].

Bottom Line: The kidneys were removed after 4 days of injections, and histological evaluations were performed.The data were analyzed using one-way analysis of variance followed by Tukey's post-hoc test, paired-sample t-test, Kruskal-Wallis and Mann-Whitney tests.These parameters reached to the normal range after administration of fruit extracts of TT for 4 days.

View Article: PubMed Central - PubMed

Affiliation: Fertility and Infertility Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran.

ABSTRACT

Background: According beneficial effects of Tribulus terrestris (TT) extract on tissue damage, the present study investigated the influence of hydroalcoholic extract of TT plant on cisplatin (CIS) (EBEWE Pharma, Unterach, Austria) induced renal tissue damage in male mice.

Methods: Thirty mice were divided into five groups (n = 6). The first group (control) was treated with normal saline (0.9% NaCl) and experimental groups with CIS (E1), CIS + 100 mg/kg extract of TT (E2), CIS + 300 mg/kg extract of TT (E3), CIS + 500 mg/kg extract of TT (E4) intraperitoneally. The kidneys were removed after 4 days of injections, and histological evaluations were performed.

Results: The data were analyzed using one-way analysis of variance followed by Tukey's post-hoc test, paired-sample t-test, Kruskal-Wallis and Mann-Whitney tests. In the CIS treated group, the whole kidney tissue showed an increased dilatation of Bowman's capsule, medullar congestion, and dilatation of collecting tubules and a decreased in the body weight and kidney weight. These parameters reached to the normal range after administration of fruit extracts of TT for 4 days.

Conclusions: The results suggested that the oral administration of TT fruit extract at dose 100, 300 and 500 mg/kg body weight provided protection against the CIS induced toxicity in the mice.

No MeSH data available.


Related in: MedlinePlus