Limits...
Seasonality and Physician-related Factors Associated with Antibiotic Prescribing: A Cross-sectional Study in Isfahan, Iran.

Safaeian L, Mahdanian AR, Salami S, Pakmehr F, Mansourian M - Int J Prev Med (2015)

Bottom Line: Over-prescription of penicillins was associated with female gender (odds ratio [OR], 2.61; 95% confidence interval [CI] 2.13-3.19) and with moderate duration of time in practice (10-20 years) (OR, 1.42; 95% CI 1.14-1.76).These findings showed the widespread use of antibiotics by general practitioners that was associated with the physicians' gender, time since graduation and practice location and also season of prescribing.More researches are needed on other factors related to the overprescribing of antibiotics and they could be used to project educational programs for improvement of antibiotic prescribing quality in our country.

View Article: PubMed Central - PubMed

Affiliation: Department of Pharmacology and Toxicology, Isfahan Pharmaceutical Sciences Research Center, School of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan, Iran.

ABSTRACT

Background: Irrational antibiotic prescribing as a global health problem has a major influence on medical care quality and healthcare expenditure. This study was aimed to determine the pattern of antibiotic use and to assess the seasonality and physician-related factors associated with variability in antibiotic prescribing in Isfahan province of Iran.

Methods: This cross-sectional survey was conducted on all prescriptions issued by general physicians from rural and urban areas in 2011. Associations between season of prescribing and physician-related variables including gender, practice location and time since graduation with antibiotic prescriptions and also the pattern of antibiotic prescribing were assessed using Chi-square tests and multiple logistic regression models.

Results: Of the 7439709 prescriptions issued by 3772 general practitioners, 51% contained at least one antibiotic. Penicillins were the most frequently prescribed antibiotics, followed by cephalosporins and macrolides. Over-prescription of penicillins was associated with female gender (odds ratio [OR], 2.61; 95% confidence interval [CI] 2.13-3.19) and with moderate duration of time in practice (10-20 years) (OR, 1.42; 95% CI 1.14-1.76). Higher rates of cephalosporins prescription were observed in urban areas than rural areas and by male physicians. Seasonal peak was detected for penicillins and cephalosporins prescriptions in autumn.

Conclusions: These findings showed the widespread use of antibiotics by general practitioners that was associated with the physicians' gender, time since graduation and practice location and also season of prescribing. More researches are needed on other factors related to the overprescribing of antibiotics and they could be used to project educational programs for improvement of antibiotic prescribing quality in our country.

No MeSH data available.


Related in: MedlinePlus

Pattern of antibiotic prescribing by general physicians in Isfahan province of Iran, 2011
© Copyright Policy - open-access
Related In: Results  -  Collection

License
getmorefigures.php?uid=PMC4362280&req=5

Figure 1: Pattern of antibiotic prescribing by general physicians in Isfahan province of Iran, 2011

Mentions: Of the 7439709 prescriptions issued by 3772 general practitioners, 51% contained at least one antibiotic. It is noteworthy that there is also over the counter purchase of antibiotics in Iran. Demographic characteristics are presented in Table 1. Male physicians outnumbered females (74.5%). Most physicians were working on urban places (67.4%) and have 10–20 years experiences. The pattern of antibiotic prescribing showed that penicillins were the most frequently prescribed antibiotics and 23.55% of patients received penicillins, followed by cephalosporins (13.4%), macrolides (5.26%) and quinolones (3.19%) [Figure 1]. Amoxicillin (7.5%) happened to be the most prescribed penicillins, followed by co-amoxiclav (5.3%), penicillin 6.3.3 (5.23%), benzathine penicillin G (2.7%), procaine penicillin G (2.47%) and ampicillin (0.35%). The frequency of prescribed cephalosporins was as cephalexin (2%) and cefazolin (0.5) in the first generation, and cefixime (8.2%) and ceftriaxone (2.7%) in the third generation. The mainly prescribed macrolides were azithromycin (4.16%) and erythromycin (1.1%). Ciprofloxacin (3.14%) and ofloxacin (0.05) were the mainly prescribed quinolones.


Seasonality and Physician-related Factors Associated with Antibiotic Prescribing: A Cross-sectional Study in Isfahan, Iran.

Safaeian L, Mahdanian AR, Salami S, Pakmehr F, Mansourian M - Int J Prev Med (2015)

Pattern of antibiotic prescribing by general physicians in Isfahan province of Iran, 2011
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4362280&req=5

Figure 1: Pattern of antibiotic prescribing by general physicians in Isfahan province of Iran, 2011
Mentions: Of the 7439709 prescriptions issued by 3772 general practitioners, 51% contained at least one antibiotic. It is noteworthy that there is also over the counter purchase of antibiotics in Iran. Demographic characteristics are presented in Table 1. Male physicians outnumbered females (74.5%). Most physicians were working on urban places (67.4%) and have 10–20 years experiences. The pattern of antibiotic prescribing showed that penicillins were the most frequently prescribed antibiotics and 23.55% of patients received penicillins, followed by cephalosporins (13.4%), macrolides (5.26%) and quinolones (3.19%) [Figure 1]. Amoxicillin (7.5%) happened to be the most prescribed penicillins, followed by co-amoxiclav (5.3%), penicillin 6.3.3 (5.23%), benzathine penicillin G (2.7%), procaine penicillin G (2.47%) and ampicillin (0.35%). The frequency of prescribed cephalosporins was as cephalexin (2%) and cefazolin (0.5) in the first generation, and cefixime (8.2%) and ceftriaxone (2.7%) in the third generation. The mainly prescribed macrolides were azithromycin (4.16%) and erythromycin (1.1%). Ciprofloxacin (3.14%) and ofloxacin (0.05) were the mainly prescribed quinolones.

Bottom Line: Over-prescription of penicillins was associated with female gender (odds ratio [OR], 2.61; 95% confidence interval [CI] 2.13-3.19) and with moderate duration of time in practice (10-20 years) (OR, 1.42; 95% CI 1.14-1.76).These findings showed the widespread use of antibiotics by general practitioners that was associated with the physicians' gender, time since graduation and practice location and also season of prescribing.More researches are needed on other factors related to the overprescribing of antibiotics and they could be used to project educational programs for improvement of antibiotic prescribing quality in our country.

View Article: PubMed Central - PubMed

Affiliation: Department of Pharmacology and Toxicology, Isfahan Pharmaceutical Sciences Research Center, School of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan, Iran.

ABSTRACT

Background: Irrational antibiotic prescribing as a global health problem has a major influence on medical care quality and healthcare expenditure. This study was aimed to determine the pattern of antibiotic use and to assess the seasonality and physician-related factors associated with variability in antibiotic prescribing in Isfahan province of Iran.

Methods: This cross-sectional survey was conducted on all prescriptions issued by general physicians from rural and urban areas in 2011. Associations between season of prescribing and physician-related variables including gender, practice location and time since graduation with antibiotic prescriptions and also the pattern of antibiotic prescribing were assessed using Chi-square tests and multiple logistic regression models.

Results: Of the 7439709 prescriptions issued by 3772 general practitioners, 51% contained at least one antibiotic. Penicillins were the most frequently prescribed antibiotics, followed by cephalosporins and macrolides. Over-prescription of penicillins was associated with female gender (odds ratio [OR], 2.61; 95% confidence interval [CI] 2.13-3.19) and with moderate duration of time in practice (10-20 years) (OR, 1.42; 95% CI 1.14-1.76). Higher rates of cephalosporins prescription were observed in urban areas than rural areas and by male physicians. Seasonal peak was detected for penicillins and cephalosporins prescriptions in autumn.

Conclusions: These findings showed the widespread use of antibiotics by general practitioners that was associated with the physicians' gender, time since graduation and practice location and also season of prescribing. More researches are needed on other factors related to the overprescribing of antibiotics and they could be used to project educational programs for improvement of antibiotic prescribing quality in our country.

No MeSH data available.


Related in: MedlinePlus