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Synbiotics in Children with Cow's Milk Allergy: A Randomized Controlled Trial.

Ahanchian H, Nouri Z, Jafari SA, Moghiman T, Amirian MH, Ezzati A, Kianifar HR - Iran J Pediatr (2014)

Bottom Line: The most effective treatment is restricting the cow `s milk protein in mother and infant`s diet.There was no significant difference in resolution of clinical gastrointestinal symptoms (vomiting, colic, rectal bleeding or diarrhea) and percentage of increment in body length.Synbiotic supplementation in infants may improve increment of head circumference and weight gain, but has no effect on resolution of clinical symptoms.

View Article: PubMed Central - PubMed

Affiliation: Department of Pediatric Allergy and Immunology.

ABSTRACT

Objective: Cow`s milk protein allergy usually occurs in infants within the first months of life. It can affect several organs, but gastrointestinal symptoms are the most clinical symptoms observed. The most effective treatment is restricting the cow `s milk protein in mother and infant`s diet. Lactobacillus GG supplementation in infant could be effective through modulation of the immune system and the gut microflora.

Methods: Thirty two breastfed infants with cow`s milk protein allergy were enrolled in a double-blinded randomized controlled trial in which they received Synbiotic (n=16) or placebo (n=16) once a day for one month, simultaneously with cow`s milk protein restriction in mother and infant`s diet. Clinical gastrointestinal symptoms (vomiting, colic, rectal bleeding and diarrhea), head circumference, body length and weight were recorded at the beginning, the end of the first and third month of study. Findings : Percentage of increment in head circumference and weight were statistically more in synbiotic group compared with placebo group at the end of the first and third month of study. There was no significant difference in resolution of clinical gastrointestinal symptoms (vomiting, colic, rectal bleeding or diarrhea) and percentage of increment in body length.

Conclusion: Synbiotic supplementation in infants may improve increment of head circumference and weight gain, but has no effect on resolution of clinical symptoms.

No MeSH data available.


Related in: MedlinePlus

Flow diagram of the study
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Figure 1: Flow diagram of the study

Mentions: This was a randomized double blind clinical trial performed from February 2009 to December 2010 in the pediatric allergy and gastrointestinal clinics of Ghaem education and research center, Mashhad, Iran. Totally 32 infants were randomly divided into the study and placebo groups each consisting of 16 cases (Fig. 1). The inclusion criteria consisted of 1-12 month-old infants with the clinical symptoms of cow's milk protein allergy including rectal bleeding, diarrhea, vomiting and evidences of colitis with complete resolution of symptoms following exclusion of dairy products from diet of mother and infant and confirmed by reappearance of symptoms after reintroducing dairy products, a good general condition, breast milk feeding and cow's milk consuming mother.


Synbiotics in Children with Cow's Milk Allergy: A Randomized Controlled Trial.

Ahanchian H, Nouri Z, Jafari SA, Moghiman T, Amirian MH, Ezzati A, Kianifar HR - Iran J Pediatr (2014)

Flow diagram of the study
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4359601&req=5

Figure 1: Flow diagram of the study
Mentions: This was a randomized double blind clinical trial performed from February 2009 to December 2010 in the pediatric allergy and gastrointestinal clinics of Ghaem education and research center, Mashhad, Iran. Totally 32 infants were randomly divided into the study and placebo groups each consisting of 16 cases (Fig. 1). The inclusion criteria consisted of 1-12 month-old infants with the clinical symptoms of cow's milk protein allergy including rectal bleeding, diarrhea, vomiting and evidences of colitis with complete resolution of symptoms following exclusion of dairy products from diet of mother and infant and confirmed by reappearance of symptoms after reintroducing dairy products, a good general condition, breast milk feeding and cow's milk consuming mother.

Bottom Line: The most effective treatment is restricting the cow `s milk protein in mother and infant`s diet.There was no significant difference in resolution of clinical gastrointestinal symptoms (vomiting, colic, rectal bleeding or diarrhea) and percentage of increment in body length.Synbiotic supplementation in infants may improve increment of head circumference and weight gain, but has no effect on resolution of clinical symptoms.

View Article: PubMed Central - PubMed

Affiliation: Department of Pediatric Allergy and Immunology.

ABSTRACT

Objective: Cow`s milk protein allergy usually occurs in infants within the first months of life. It can affect several organs, but gastrointestinal symptoms are the most clinical symptoms observed. The most effective treatment is restricting the cow `s milk protein in mother and infant`s diet. Lactobacillus GG supplementation in infant could be effective through modulation of the immune system and the gut microflora.

Methods: Thirty two breastfed infants with cow`s milk protein allergy were enrolled in a double-blinded randomized controlled trial in which they received Synbiotic (n=16) or placebo (n=16) once a day for one month, simultaneously with cow`s milk protein restriction in mother and infant`s diet. Clinical gastrointestinal symptoms (vomiting, colic, rectal bleeding and diarrhea), head circumference, body length and weight were recorded at the beginning, the end of the first and third month of study. Findings : Percentage of increment in head circumference and weight were statistically more in synbiotic group compared with placebo group at the end of the first and third month of study. There was no significant difference in resolution of clinical gastrointestinal symptoms (vomiting, colic, rectal bleeding or diarrhea) and percentage of increment in body length.

Conclusion: Synbiotic supplementation in infants may improve increment of head circumference and weight gain, but has no effect on resolution of clinical symptoms.

No MeSH data available.


Related in: MedlinePlus