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A case report of eosinophilic myocarditis and a review of the relevant literature.

Li H, Dai Z, Wang B, Huang W - BMC Cardiovasc Disord (2015)

Bottom Line: Symptoms may be severe, and, lead to rapidly-fatal outcomes.Finally, high-dose corticosteroids were used to reverse the cardiac injury and to improve the clinical outcome.Antituberculosis drugs can cause eosinophilic infiltration of, and damage to, the myocardium leading to rapid progression of the clinical symptoms.

View Article: PubMed Central - PubMed

Affiliation: Department of Cardiology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325000, China. lihaiying111@gmail.com.

ABSTRACT

Background: Eosinophilic myocarditis (EM) is a relatively rare condition that may result from parasitic infections and allergic disease. Antituberculosis drugs may lead to focal myocardial infiltration by eosinophils (eosinophilic myocarditis). Symptoms may be severe, and, lead to rapidly-fatal outcomes. Early diagnosis and high-dose corticosteroids are the cornerstone of treatment, and, may lead to restoration of cardiac function with full recovery.

Case presentation: We report a case of eosinophilic myocarditis secondary to eosinophilia caused by antituberculosis drugs with markedly elevated ECP, focal eosinophilic infiltration in CMR imaging and endomyocardial biopsy. Finally, high-dose corticosteroids were used to reverse the cardiac injury and to improve the clinical outcome.

Conclusion: Antituberculosis drugs can cause eosinophilic infiltration of, and damage to, the myocardium leading to rapid progression of the clinical symptoms. Myocardial biopsy is helpful in diagnosing the disease in the early stages and high-dose corticosteroids effectively improves the prognosis of this disease.

No MeSH data available.


Related in: MedlinePlus

Echocardiography and left ventricular angiography. A. Echocardiography revealed normal movement of the ventricular wall and deteriorated diastolic function (left ventricular end diastolic diameter (LVEDD), 47 mm; interventricular septum thickness (IVS), 12 mm; left ventricular ejection fraction (LVEF), 50.8%). Coronary angiography showed that there was no stenosis or obstructive lesions in the coronary artery; B. Left ventricular angiography showed thickening of the apical ventricular membrane.
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Fig2: Echocardiography and left ventricular angiography. A. Echocardiography revealed normal movement of the ventricular wall and deteriorated diastolic function (left ventricular end diastolic diameter (LVEDD), 47 mm; interventricular septum thickness (IVS), 12 mm; left ventricular ejection fraction (LVEF), 50.8%). Coronary angiography showed that there was no stenosis or obstructive lesions in the coronary artery; B. Left ventricular angiography showed thickening of the apical ventricular membrane.

Mentions: On March 13, 2012, coronary angiography showed that there was no stenosis or obstructive lesions in the coronary artery. Left ventricular angiography revealed thickening of the apical ventricular membrane (Figure 2). Swan-Ganz catheterization indicated normal systolic function with disordered cardiac diastolic function, which recovered substantially after blood pressure stabilization treatment and adequate fluid infusion (Table 1).Figure 2


A case report of eosinophilic myocarditis and a review of the relevant literature.

Li H, Dai Z, Wang B, Huang W - BMC Cardiovasc Disord (2015)

Echocardiography and left ventricular angiography. A. Echocardiography revealed normal movement of the ventricular wall and deteriorated diastolic function (left ventricular end diastolic diameter (LVEDD), 47 mm; interventricular septum thickness (IVS), 12 mm; left ventricular ejection fraction (LVEF), 50.8%). Coronary angiography showed that there was no stenosis or obstructive lesions in the coronary artery; B. Left ventricular angiography showed thickening of the apical ventricular membrane.
© Copyright Policy - open-access
Related In: Results  -  Collection

License 1 - License 2
Show All Figures
getmorefigures.php?uid=PMC4359588&req=5

Fig2: Echocardiography and left ventricular angiography. A. Echocardiography revealed normal movement of the ventricular wall and deteriorated diastolic function (left ventricular end diastolic diameter (LVEDD), 47 mm; interventricular septum thickness (IVS), 12 mm; left ventricular ejection fraction (LVEF), 50.8%). Coronary angiography showed that there was no stenosis or obstructive lesions in the coronary artery; B. Left ventricular angiography showed thickening of the apical ventricular membrane.
Mentions: On March 13, 2012, coronary angiography showed that there was no stenosis or obstructive lesions in the coronary artery. Left ventricular angiography revealed thickening of the apical ventricular membrane (Figure 2). Swan-Ganz catheterization indicated normal systolic function with disordered cardiac diastolic function, which recovered substantially after blood pressure stabilization treatment and adequate fluid infusion (Table 1).Figure 2

Bottom Line: Symptoms may be severe, and, lead to rapidly-fatal outcomes.Finally, high-dose corticosteroids were used to reverse the cardiac injury and to improve the clinical outcome.Antituberculosis drugs can cause eosinophilic infiltration of, and damage to, the myocardium leading to rapid progression of the clinical symptoms.

View Article: PubMed Central - PubMed

Affiliation: Department of Cardiology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325000, China. lihaiying111@gmail.com.

ABSTRACT

Background: Eosinophilic myocarditis (EM) is a relatively rare condition that may result from parasitic infections and allergic disease. Antituberculosis drugs may lead to focal myocardial infiltration by eosinophils (eosinophilic myocarditis). Symptoms may be severe, and, lead to rapidly-fatal outcomes. Early diagnosis and high-dose corticosteroids are the cornerstone of treatment, and, may lead to restoration of cardiac function with full recovery.

Case presentation: We report a case of eosinophilic myocarditis secondary to eosinophilia caused by antituberculosis drugs with markedly elevated ECP, focal eosinophilic infiltration in CMR imaging and endomyocardial biopsy. Finally, high-dose corticosteroids were used to reverse the cardiac injury and to improve the clinical outcome.

Conclusion: Antituberculosis drugs can cause eosinophilic infiltration of, and damage to, the myocardium leading to rapid progression of the clinical symptoms. Myocardial biopsy is helpful in diagnosing the disease in the early stages and high-dose corticosteroids effectively improves the prognosis of this disease.

No MeSH data available.


Related in: MedlinePlus