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Estimation of the cutoff value of vitamin D: the Dong-gu study.

Choi SW, Kweon SS, Choi JS, Rhee JA, Lee YH, Nam HS, Jeong SK, Park KS, Ryu SY, Song HR, Shin MH - J Physiol Anthropol (2015)

Bottom Line: Serum 25(OH)D and PTH concentrations were measured by chemiluminescent microparticle immunoassay.Our data show that PTH concentration reached a theoretical plateau at 38.2 pg/ml and corresponding 25(OH)D concentration was 21.1 ng/ml in men and PTH concentration at 42.9 pg/ml and 25(OH)D concentration at 13.8 ng/ml in women.These results indicate that, for Korean general population aged 50 years or older, the optimal 25(OH)D concentration is 21.1 ng/ml in men and 13.8 ng/ml in women.

View Article: PubMed Central - PubMed

ABSTRACT

Background: Vitamin D plays an essential role in bone health and growth, but the optimal serum 25-hydroxyvitamin D (25(OH)D) concentration is not known. This study was performed to investigate the optimal 25(OH)D concentration in regard to parathyroid hormone (PTH) concentration in the Korean general population aged 50 years or older.

Findings: The study population consisted of 8,857 subjects (3,545 men and 5,312 women) who participated in the baseline survey of the Dong-gu study, conducted in Korea between 2007 and 2010. Serum 25(OH)D and PTH concentrations were measured by chemiluminescent microparticle immunoassay. The optimal 25(OH)D concentration was estimated by using nonlinear regression model. Our data show that PTH concentration reached a theoretical plateau at 38.2 pg/ml and corresponding 25(OH)D concentration was 21.1 ng/ml in men and PTH concentration at 42.9 pg/ml and 25(OH)D concentration at 13.8 ng/ml in women.

Conclusions: These results indicate that, for Korean general population aged 50 years or older, the optimal 25(OH)D concentration is 21.1 ng/ml in men and 13.8 ng/ml in women.

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25(OH)D concentrationversusparathyroid hormone concentration (males).
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Fig1: 25(OH)D concentrationversusparathyroid hormone concentration (males).

Mentions: With this approach, the PTH concentration reached a theoretical plateau at 38.2 pg/ml and the corresponding 25(OH)D concentration was 21.1 ng/ml in men (Figure 1) and the PTH concentration at 42.9 pg/ml and the 25(OH)D concentration at 13.8 ng/ml in women (Figure 2).Figure 1


Estimation of the cutoff value of vitamin D: the Dong-gu study.

Choi SW, Kweon SS, Choi JS, Rhee JA, Lee YH, Nam HS, Jeong SK, Park KS, Ryu SY, Song HR, Shin MH - J Physiol Anthropol (2015)

25(OH)D concentrationversusparathyroid hormone concentration (males).
© Copyright Policy - open-access
Related In: Results  -  Collection

License 1 - License 2
Show All Figures
getmorefigures.php?uid=PMC4359542&req=5

Fig1: 25(OH)D concentrationversusparathyroid hormone concentration (males).
Mentions: With this approach, the PTH concentration reached a theoretical plateau at 38.2 pg/ml and the corresponding 25(OH)D concentration was 21.1 ng/ml in men (Figure 1) and the PTH concentration at 42.9 pg/ml and the 25(OH)D concentration at 13.8 ng/ml in women (Figure 2).Figure 1

Bottom Line: Serum 25(OH)D and PTH concentrations were measured by chemiluminescent microparticle immunoassay.Our data show that PTH concentration reached a theoretical plateau at 38.2 pg/ml and corresponding 25(OH)D concentration was 21.1 ng/ml in men and PTH concentration at 42.9 pg/ml and 25(OH)D concentration at 13.8 ng/ml in women.These results indicate that, for Korean general population aged 50 years or older, the optimal 25(OH)D concentration is 21.1 ng/ml in men and 13.8 ng/ml in women.

View Article: PubMed Central - PubMed

ABSTRACT

Background: Vitamin D plays an essential role in bone health and growth, but the optimal serum 25-hydroxyvitamin D (25(OH)D) concentration is not known. This study was performed to investigate the optimal 25(OH)D concentration in regard to parathyroid hormone (PTH) concentration in the Korean general population aged 50 years or older.

Findings: The study population consisted of 8,857 subjects (3,545 men and 5,312 women) who participated in the baseline survey of the Dong-gu study, conducted in Korea between 2007 and 2010. Serum 25(OH)D and PTH concentrations were measured by chemiluminescent microparticle immunoassay. The optimal 25(OH)D concentration was estimated by using nonlinear regression model. Our data show that PTH concentration reached a theoretical plateau at 38.2 pg/ml and corresponding 25(OH)D concentration was 21.1 ng/ml in men and PTH concentration at 42.9 pg/ml and 25(OH)D concentration at 13.8 ng/ml in women.

Conclusions: These results indicate that, for Korean general population aged 50 years or older, the optimal 25(OH)D concentration is 21.1 ng/ml in men and 13.8 ng/ml in women.

Show MeSH
Related in: MedlinePlus