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Efficacy of laparoscopic adenomyomectomy using double-flap method for diffuse uterine adenomyosis.

Huang X, Huang Q, Chen S, Zhang J, Lin K, Zhang X - BMC Womens Health (2015)

Bottom Line: The VAS scores, menstrual amount, serum CA125 levels, and uterine volume at 12 or 24 months after surgery significantly reduced in group B than in group A (P < 0.05); these parameters were statistically decreased in both groups after surgery compared with those obtained before surgery (P < 0.001).Moreover, serum CA125 levels and uterine volume at six months of follow up were significantly lower in group B than in group A (P < 0.01).In addition, blood loss during surgery was similar in groups A and B (P > 0.05), although the operative time was significantly longer in group B than that in group A (P < 0.05).

View Article: PubMed Central - PubMed

Affiliation: The Department of Gynecology, Women's Hospital, Zhejiang University School of Medicine, 1 Xueshi Road, Hangzhou, Zhejiang, 310006, P. R. China, huangxiufeng73@163.com.

ABSTRACT

Background: Adenomyomectomy has recently been considered the priority option for the treatment of adenomyosis, however, the surgical efficacy and modes are still debated. We aimed to evaluate the efficacy of laparoscopic adenomyomectomy using a double-flap method for the treatment of uterine diffuse adenomyosis when compared with conventional laparoscopic adenomyomectomy.

Methods: Laparoscopic adenomyomectomy using the conventional method (group A, n = 48) and the double-flap method (group B, n = 46) to treat diffuse uterine adenomyosis, respectively. Visual analog scale (VAS), menstrual amount, serum CA125 levels, and uterine volume were comparatively analyzed in both groups.

Results: The VAS scores, menstrual amount, serum CA125 levels, and uterine volume at 12 or 24 months after surgery significantly reduced in group B than in group A (P < 0.05); these parameters were statistically decreased in both groups after surgery compared with those obtained before surgery (P < 0.001). Moreover, serum CA125 levels and uterine volume at six months of follow up were significantly lower in group B than in group A (P < 0.01). In addition, blood loss during surgery was similar in groups A and B (P > 0.05), although the operative time was significantly longer in group B than that in group A (P < 0.05).

Conclusions: Laparoscopic adenomyomectomy using the double-flap method may be an effective technique to treat uterine diffuse adenomyosis.

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Related in: MedlinePlus

Changes of serum CA125 levels, uterine size, pain scores, and menorrhagia before and after surgery in groups A and B. Group A = Conventional method, Group B = Double-flap method.
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Fig3: Changes of serum CA125 levels, uterine size, pain scores, and menorrhagia before and after surgery in groups A and B. Group A = Conventional method, Group B = Double-flap method.

Mentions: No significant differences in age, gravidity, parity, abortion, hemoglobin levels, uterine volume, VAS score, menorrhagia, and serum CA125 levels were found between the two groups (P > 0.05, Table 1). Six months after surgery, five patients (5/48, 10.4%) in group A and two patients (2/46, 4.3%) in group B still exhibited pain symptoms with VAS scores of ≤2. The VAS scores at six-month follow-up period in group A or B significantly decreased compared with those before surgery (P <0.0001), but no statistically significant differences were found between groups A and B (P > 0.05, Table 2, Figure 3). Uterine size and serum CA125 levels six months after surgery were significantly higher in group A than in group B (P < 0.0001), although both parameters in each group were statistically decreased compared with those obtained before surgery (P <0.0001, Table 2, Figure 3).Table 1


Efficacy of laparoscopic adenomyomectomy using double-flap method for diffuse uterine adenomyosis.

Huang X, Huang Q, Chen S, Zhang J, Lin K, Zhang X - BMC Womens Health (2015)

Changes of serum CA125 levels, uterine size, pain scores, and menorrhagia before and after surgery in groups A and B. Group A = Conventional method, Group B = Double-flap method.
© Copyright Policy - open-access
Related In: Results  -  Collection

License 1 - License 2
Show All Figures
getmorefigures.php?uid=PMC4359498&req=5

Fig3: Changes of serum CA125 levels, uterine size, pain scores, and menorrhagia before and after surgery in groups A and B. Group A = Conventional method, Group B = Double-flap method.
Mentions: No significant differences in age, gravidity, parity, abortion, hemoglobin levels, uterine volume, VAS score, menorrhagia, and serum CA125 levels were found between the two groups (P > 0.05, Table 1). Six months after surgery, five patients (5/48, 10.4%) in group A and two patients (2/46, 4.3%) in group B still exhibited pain symptoms with VAS scores of ≤2. The VAS scores at six-month follow-up period in group A or B significantly decreased compared with those before surgery (P <0.0001), but no statistically significant differences were found between groups A and B (P > 0.05, Table 2, Figure 3). Uterine size and serum CA125 levels six months after surgery were significantly higher in group A than in group B (P < 0.0001), although both parameters in each group were statistically decreased compared with those obtained before surgery (P <0.0001, Table 2, Figure 3).Table 1

Bottom Line: The VAS scores, menstrual amount, serum CA125 levels, and uterine volume at 12 or 24 months after surgery significantly reduced in group B than in group A (P < 0.05); these parameters were statistically decreased in both groups after surgery compared with those obtained before surgery (P < 0.001).Moreover, serum CA125 levels and uterine volume at six months of follow up were significantly lower in group B than in group A (P < 0.01).In addition, blood loss during surgery was similar in groups A and B (P > 0.05), although the operative time was significantly longer in group B than that in group A (P < 0.05).

View Article: PubMed Central - PubMed

Affiliation: The Department of Gynecology, Women's Hospital, Zhejiang University School of Medicine, 1 Xueshi Road, Hangzhou, Zhejiang, 310006, P. R. China, huangxiufeng73@163.com.

ABSTRACT

Background: Adenomyomectomy has recently been considered the priority option for the treatment of adenomyosis, however, the surgical efficacy and modes are still debated. We aimed to evaluate the efficacy of laparoscopic adenomyomectomy using a double-flap method for the treatment of uterine diffuse adenomyosis when compared with conventional laparoscopic adenomyomectomy.

Methods: Laparoscopic adenomyomectomy using the conventional method (group A, n = 48) and the double-flap method (group B, n = 46) to treat diffuse uterine adenomyosis, respectively. Visual analog scale (VAS), menstrual amount, serum CA125 levels, and uterine volume were comparatively analyzed in both groups.

Results: The VAS scores, menstrual amount, serum CA125 levels, and uterine volume at 12 or 24 months after surgery significantly reduced in group B than in group A (P < 0.05); these parameters were statistically decreased in both groups after surgery compared with those obtained before surgery (P < 0.001). Moreover, serum CA125 levels and uterine volume at six months of follow up were significantly lower in group B than in group A (P < 0.01). In addition, blood loss during surgery was similar in groups A and B (P > 0.05), although the operative time was significantly longer in group B than that in group A (P < 0.05).

Conclusions: Laparoscopic adenomyomectomy using the double-flap method may be an effective technique to treat uterine diffuse adenomyosis.

Show MeSH
Related in: MedlinePlus