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Food allergy in the Netherlands: differences in clinical severity, causative foods, sensitization and DBPCFC between community and outpatients.

Le TM, van Hoffen E, Kummeling I, Potts J, Ballmer-Weber BK, Bruijnzeel-Koomen CA, Lebens AF, Lidholm J, Lindner TM, Mackie A, Mills EC, van Ree R, Vieths S, Fernández-Rivas M, Burney PG, Knulst AC - Clin Transl Allergy (2015)

Bottom Line: When selecting only those with a probable FA (i.e. symptoms of priority food and elevation of sIgE to the respective food), no major differences were observed with respect to severity, causative foods, sensitization and DBPCFC between the groups.In the Netherlands, there are large differences in self-reported FA between community and outpatients.However, Dutch community and outpatients with a probable FA do not differ with respect to severity, causative foods, sensitization and DBPCFC-outcome.

View Article: PubMed Central - PubMed

Affiliation: Department of Dermatology/Allergology, University Medical Center Utrecht, PO Box 85500, 3508 GA Utrecht, The Netherlands.

ABSTRACT

Background: It is unknown whether food allergy (FA) in an unselected population is comparable to those from an outpatient clinic population.

Objective: To discover if FA in a random sample from the Dutch community is comparable to that of outpatients.

Methods: This study was part of the Europrevall-project. A random sample of 6600 adults received a questionnaire. Those with symptoms to one of 24 defined priority foods were tested for sIgE. Participants with a positive case history and elevated sIgE were evaluated by double-blind placebo-controlled food challenge (DBPCFC). Outpatients with a suspicion of FA were evaluated by questionnaire, sIgE and DBPCFC.

Results: In the community, severe symptoms were reported less often than in outpatients (39.3% vs. 54.3%). Participants in the community were less commonly sensitized to any of the foods. When selecting only those with a probable FA (i.e. symptoms of priority food and elevation of sIgE to the respective food), no major differences were observed with respect to severity, causative foods, sensitization and DBPCFC between the groups.

Conclusion: In the Netherlands, there are large differences in self-reported FA between community and outpatients. However, Dutch community and outpatients with a probable FA do not differ with respect to severity, causative foods, sensitization and DBPCFC-outcome.

No MeSH data available.


Related in: MedlinePlus

Percentage of positive sIgE in the community and outpatients with symptoms to the food in the 2nd stage (reported symptoms) and 3rd stage (reported symptoms and positive sIgE for at least 1 food) of the study. The number (n = ..) between brackets indicates the total number of the community and outpatients that reported symptoms to that respective priority food. *p-value <0.05.
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Fig2: Percentage of positive sIgE in the community and outpatients with symptoms to the food in the 2nd stage (reported symptoms) and 3rd stage (reported symptoms and positive sIgE for at least 1 food) of the study. The number (n = ..) between brackets indicates the total number of the community and outpatients that reported symptoms to that respective priority food. *p-value <0.05.

Mentions: Of the participants reporting adverse reactions to any food (n = 967), 43.0% reported symptoms to at least one of the priority foods. Walnut, apple, cow’s milk, hazelnut and kiwi were the most commonly reported priority foods in the community (Table 1, 2nd stage). The frequency of severe symptoms rose from 21.4% in the 1st stage to 39.3% in the 2nd stage in participants from the community. Remarkably, only a small percentage of participants from the community who reported symptoms to priority foods also had a positive sIgE for the respective food (Figure 2).Table 1


Food allergy in the Netherlands: differences in clinical severity, causative foods, sensitization and DBPCFC between community and outpatients.

Le TM, van Hoffen E, Kummeling I, Potts J, Ballmer-Weber BK, Bruijnzeel-Koomen CA, Lebens AF, Lidholm J, Lindner TM, Mackie A, Mills EC, van Ree R, Vieths S, Fernández-Rivas M, Burney PG, Knulst AC - Clin Transl Allergy (2015)

Percentage of positive sIgE in the community and outpatients with symptoms to the food in the 2nd stage (reported symptoms) and 3rd stage (reported symptoms and positive sIgE for at least 1 food) of the study. The number (n = ..) between brackets indicates the total number of the community and outpatients that reported symptoms to that respective priority food. *p-value <0.05.
© Copyright Policy - open-access
Related In: Results  -  Collection

License 1 - License 2
Show All Figures
getmorefigures.php?uid=PMC4359480&req=5

Fig2: Percentage of positive sIgE in the community and outpatients with symptoms to the food in the 2nd stage (reported symptoms) and 3rd stage (reported symptoms and positive sIgE for at least 1 food) of the study. The number (n = ..) between brackets indicates the total number of the community and outpatients that reported symptoms to that respective priority food. *p-value <0.05.
Mentions: Of the participants reporting adverse reactions to any food (n = 967), 43.0% reported symptoms to at least one of the priority foods. Walnut, apple, cow’s milk, hazelnut and kiwi were the most commonly reported priority foods in the community (Table 1, 2nd stage). The frequency of severe symptoms rose from 21.4% in the 1st stage to 39.3% in the 2nd stage in participants from the community. Remarkably, only a small percentage of participants from the community who reported symptoms to priority foods also had a positive sIgE for the respective food (Figure 2).Table 1

Bottom Line: When selecting only those with a probable FA (i.e. symptoms of priority food and elevation of sIgE to the respective food), no major differences were observed with respect to severity, causative foods, sensitization and DBPCFC between the groups.In the Netherlands, there are large differences in self-reported FA between community and outpatients.However, Dutch community and outpatients with a probable FA do not differ with respect to severity, causative foods, sensitization and DBPCFC-outcome.

View Article: PubMed Central - PubMed

Affiliation: Department of Dermatology/Allergology, University Medical Center Utrecht, PO Box 85500, 3508 GA Utrecht, The Netherlands.

ABSTRACT

Background: It is unknown whether food allergy (FA) in an unselected population is comparable to those from an outpatient clinic population.

Objective: To discover if FA in a random sample from the Dutch community is comparable to that of outpatients.

Methods: This study was part of the Europrevall-project. A random sample of 6600 adults received a questionnaire. Those with symptoms to one of 24 defined priority foods were tested for sIgE. Participants with a positive case history and elevated sIgE were evaluated by double-blind placebo-controlled food challenge (DBPCFC). Outpatients with a suspicion of FA were evaluated by questionnaire, sIgE and DBPCFC.

Results: In the community, severe symptoms were reported less often than in outpatients (39.3% vs. 54.3%). Participants in the community were less commonly sensitized to any of the foods. When selecting only those with a probable FA (i.e. symptoms of priority food and elevation of sIgE to the respective food), no major differences were observed with respect to severity, causative foods, sensitization and DBPCFC between the groups.

Conclusion: In the Netherlands, there are large differences in self-reported FA between community and outpatients. However, Dutch community and outpatients with a probable FA do not differ with respect to severity, causative foods, sensitization and DBPCFC-outcome.

No MeSH data available.


Related in: MedlinePlus