Limits...
Stroke patients' knowledge about cardiovascular family history - the Norwegian Stroke in the Young Study (NOR-SYS).

Øygarden H, Fromm A, Sand KM, Eide GE, Thomassen L, Naess H, Waje-Andreassen U - BMC Neurol (2015)

Bottom Line: Multiple logistic regression analyses were used to test the influence of patient sex on FH reporting and to adjust for possible confounding factors.Detailed knowledge on FH was best for CAD.Our results suggest sex has a big impact on FH knowledge.

View Article: PubMed Central - PubMed

Affiliation: Department of Clinical Medicine, University of Bergen, Bergen, Norway. havy@helse-bergen.no.

ABSTRACT

Background: Family history (FH) is a risk factor for cardiovascular disease, especially coronary artery disease (CAD). The impact on risk of stroke is less clear. This study investigated young and middle-aged ischemic stroke patients' knowledge on FH of stroke, CAD, and peripheral artery disease (PAD) with a special regard to sex differences.

Methods: From September 2010 to February 2014, all ischemic stroke patients aged 15-60 years were prospectively included in the Norwegian Stroke in the Young Study (NOR-SYS). FH of stroke, CAD and PAD in offspring, siblings, parents, and grandparents was assessed using a standardized face-to-face interview. In addition to 'yes' and 'no', the optional reply 'don't know' was included to improve accuracy. McNemar's test was used to compare paired proportions, i.e. FH in male vs. female relatives. Multiple logistic regression analyses were used to test the influence of patient sex on FH reporting and to adjust for possible confounding factors.

Results: Altogether 257 patients were included. Mean age was 49.5 years and 68.1% were males. FH of cardiovascular disease was reported by 59% of patients. When asked about FH of stroke, 48 (18.7%) and 46 (17.9%) patients reported yes, whereas 17 (6.6%) and 9 (3.5%) reported 'don't know' regarding father and mother respectively, similarly patients reported 'don't know' regarding 117 (45.5%) paternal vs. 83 (32.4%) maternal grandmothers (p < 0.001). Female patients reported less 'don't know' and were more likely to report a positive cardiovascular FH than males (OR: 3.4; 95% CI: 1.5 to 7.7; p = 0.004). Patients had more detailed knowledge about CAD than stroke in fathers (p < 0.001), mothers (p < 0.001) and siblings (p = 0.01).

Conclusions: Young and middle-aged stroke patients reported a high FH burden of cardiovascular disease. Females are more likely to report a positive FH than males. Detailed knowledge on FH was best for CAD. Our results suggest sex has a big impact on FH knowledge. Females have more knowledge of FH than males and knowledge is better for relatives with a female than male linkage.

Clinical trial registration: http://www.clinicaltrials.gov , unique identifier: NCT01597453 .

No MeSH data available.


Related in: MedlinePlus

Reported parental history of cerebrovascular disease, coronary artery disease and peripheral artery disease from the 257 young and middle-aged ischemic stroke patients included in the Stroke in the Young Study (NOR-SYS) in Bergen, Norway 2010–2014, stratified by sex. Answers ‘Yes’ and ‘Don’t know’ are displayed in percentage proportions with 95% confidence intervals of the total N, the remaining answering ‘No’.
© Copyright Policy - open-access
Related In: Results  -  Collection

License 1 - License 2
getmorefigures.php?uid=PMC4359475&req=5

Fig1: Reported parental history of cerebrovascular disease, coronary artery disease and peripheral artery disease from the 257 young and middle-aged ischemic stroke patients included in the Stroke in the Young Study (NOR-SYS) in Bergen, Norway 2010–2014, stratified by sex. Answers ‘Yes’ and ‘Don’t know’ are displayed in percentage proportions with 95% confidence intervals of the total N, the remaining answering ‘No’.

Mentions: There was a trend of more reported FH of CVD events and less frequent reporting of ‘don’t know’ among females compared to males (Figure 1). When analyzing FH of CVD in grandparents, females reported significantly less ‘don’t know’ regarding heart disease in mothers‘ mothers (p = 0.02) and of stroke in fathers’ mothers (p = 0.02). Patients reported ‘Yes’ or ‘No’ on FH of stroke in both parents in 235 (91%) cases and having knowledge of both parents’ FH was most common. Patients consistently reported less ‘don’t know’ regarding maternal FH than paternal FH (Table 4). Males reported a mean number of 1.5 (SD: 1.28) family members with CVD, whereas females reported 1.9 (SD: 1.25; p = 0.01). Females reported a positive FH more often than males with an OR of 3.4 (95% CI: 1.5 to 7.7; p < 0.01; Table 5). When analyzing a positive FH in FDRs only, females are more likely to report a positive FH with an OR of 2.5 (95% CI: 1.3 to 4.8; p < 0.01). In addition, increasing age was associated with a positive FH and higher educational category was associated with a negative FH.Figure 1


Stroke patients' knowledge about cardiovascular family history - the Norwegian Stroke in the Young Study (NOR-SYS).

Øygarden H, Fromm A, Sand KM, Eide GE, Thomassen L, Naess H, Waje-Andreassen U - BMC Neurol (2015)

Reported parental history of cerebrovascular disease, coronary artery disease and peripheral artery disease from the 257 young and middle-aged ischemic stroke patients included in the Stroke in the Young Study (NOR-SYS) in Bergen, Norway 2010–2014, stratified by sex. Answers ‘Yes’ and ‘Don’t know’ are displayed in percentage proportions with 95% confidence intervals of the total N, the remaining answering ‘No’.
© Copyright Policy - open-access
Related In: Results  -  Collection

License 1 - License 2
Show All Figures
getmorefigures.php?uid=PMC4359475&req=5

Fig1: Reported parental history of cerebrovascular disease, coronary artery disease and peripheral artery disease from the 257 young and middle-aged ischemic stroke patients included in the Stroke in the Young Study (NOR-SYS) in Bergen, Norway 2010–2014, stratified by sex. Answers ‘Yes’ and ‘Don’t know’ are displayed in percentage proportions with 95% confidence intervals of the total N, the remaining answering ‘No’.
Mentions: There was a trend of more reported FH of CVD events and less frequent reporting of ‘don’t know’ among females compared to males (Figure 1). When analyzing FH of CVD in grandparents, females reported significantly less ‘don’t know’ regarding heart disease in mothers‘ mothers (p = 0.02) and of stroke in fathers’ mothers (p = 0.02). Patients reported ‘Yes’ or ‘No’ on FH of stroke in both parents in 235 (91%) cases and having knowledge of both parents’ FH was most common. Patients consistently reported less ‘don’t know’ regarding maternal FH than paternal FH (Table 4). Males reported a mean number of 1.5 (SD: 1.28) family members with CVD, whereas females reported 1.9 (SD: 1.25; p = 0.01). Females reported a positive FH more often than males with an OR of 3.4 (95% CI: 1.5 to 7.7; p < 0.01; Table 5). When analyzing a positive FH in FDRs only, females are more likely to report a positive FH with an OR of 2.5 (95% CI: 1.3 to 4.8; p < 0.01). In addition, increasing age was associated with a positive FH and higher educational category was associated with a negative FH.Figure 1

Bottom Line: Multiple logistic regression analyses were used to test the influence of patient sex on FH reporting and to adjust for possible confounding factors.Detailed knowledge on FH was best for CAD.Our results suggest sex has a big impact on FH knowledge.

View Article: PubMed Central - PubMed

Affiliation: Department of Clinical Medicine, University of Bergen, Bergen, Norway. havy@helse-bergen.no.

ABSTRACT

Background: Family history (FH) is a risk factor for cardiovascular disease, especially coronary artery disease (CAD). The impact on risk of stroke is less clear. This study investigated young and middle-aged ischemic stroke patients' knowledge on FH of stroke, CAD, and peripheral artery disease (PAD) with a special regard to sex differences.

Methods: From September 2010 to February 2014, all ischemic stroke patients aged 15-60 years were prospectively included in the Norwegian Stroke in the Young Study (NOR-SYS). FH of stroke, CAD and PAD in offspring, siblings, parents, and grandparents was assessed using a standardized face-to-face interview. In addition to 'yes' and 'no', the optional reply 'don't know' was included to improve accuracy. McNemar's test was used to compare paired proportions, i.e. FH in male vs. female relatives. Multiple logistic regression analyses were used to test the influence of patient sex on FH reporting and to adjust for possible confounding factors.

Results: Altogether 257 patients were included. Mean age was 49.5 years and 68.1% were males. FH of cardiovascular disease was reported by 59% of patients. When asked about FH of stroke, 48 (18.7%) and 46 (17.9%) patients reported yes, whereas 17 (6.6%) and 9 (3.5%) reported 'don't know' regarding father and mother respectively, similarly patients reported 'don't know' regarding 117 (45.5%) paternal vs. 83 (32.4%) maternal grandmothers (p < 0.001). Female patients reported less 'don't know' and were more likely to report a positive cardiovascular FH than males (OR: 3.4; 95% CI: 1.5 to 7.7; p = 0.004). Patients had more detailed knowledge about CAD than stroke in fathers (p < 0.001), mothers (p < 0.001) and siblings (p = 0.01).

Conclusions: Young and middle-aged stroke patients reported a high FH burden of cardiovascular disease. Females are more likely to report a positive FH than males. Detailed knowledge on FH was best for CAD. Our results suggest sex has a big impact on FH knowledge. Females have more knowledge of FH than males and knowledge is better for relatives with a female than male linkage.

Clinical trial registration: http://www.clinicaltrials.gov , unique identifier: NCT01597453 .

No MeSH data available.


Related in: MedlinePlus