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Miniaturized plate readers for low-cost, high-throughput phenotypic screening.

Jensen PA, Dougherty BV, Moutinho TJ, Papin JA - J Lab Autom (2014)

Bottom Line: The device contains no moving parts, allowing an entire 96-well plate to be read several times per second.A wireless communication module allows remote monitoring of multiple devices in real time.These features allow easy assembly of multiple readers to create a scalable, accurate solution for high-throughput phenotypic screening.

View Article: PubMed Central - PubMed

Affiliation: Department of Biomedical Engineering, University of Virginia, Charlottesville, VA, USA Biology Department, Boston College, Chestnut Hill, MA, USA.

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Related in: MedlinePlus

(A) Close-up of the phototransistor (PT) (top) and light-emitting diode (LED) (bottom) arrays. (B) The overall dimensions of the miniaturized reader are slightly larger than those of a standard 96-well plate. (C) Eight miniaturized plate readers stacked in a standard bench top incubator.
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Related In: Results  -  Collection

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fig2-2211068214555414: (A) Close-up of the phototransistor (PT) (top) and light-emitting diode (LED) (bottom) arrays. (B) The overall dimensions of the miniaturized reader are slightly larger than those of a standard 96-well plate. (C) Eight miniaturized plate readers stacked in a standard bench top incubator.

Mentions: The LED–PT arrays were attached to an aluminum frame (Fig. 2A–B). The frames are stackable, and multiple devices fit into a bench top incubator (Fig. 2C). The bottom surface of the frame includes adjustable spacers to secure a multiwell plate. The spacing between the aluminum frames is adjustable to accommodate deep well plates or plates with thick lids.


Miniaturized plate readers for low-cost, high-throughput phenotypic screening.

Jensen PA, Dougherty BV, Moutinho TJ, Papin JA - J Lab Autom (2014)

(A) Close-up of the phototransistor (PT) (top) and light-emitting diode (LED) (bottom) arrays. (B) The overall dimensions of the miniaturized reader are slightly larger than those of a standard 96-well plate. (C) Eight miniaturized plate readers stacked in a standard bench top incubator.
© Copyright Policy - open-access
Related In: Results  -  Collection

License 1 - License 2 - License 3
Show All Figures
getmorefigures.php?uid=PMC4359207&req=5

fig2-2211068214555414: (A) Close-up of the phototransistor (PT) (top) and light-emitting diode (LED) (bottom) arrays. (B) The overall dimensions of the miniaturized reader are slightly larger than those of a standard 96-well plate. (C) Eight miniaturized plate readers stacked in a standard bench top incubator.
Mentions: The LED–PT arrays were attached to an aluminum frame (Fig. 2A–B). The frames are stackable, and multiple devices fit into a bench top incubator (Fig. 2C). The bottom surface of the frame includes adjustable spacers to secure a multiwell plate. The spacing between the aluminum frames is adjustable to accommodate deep well plates or plates with thick lids.

Bottom Line: The device contains no moving parts, allowing an entire 96-well plate to be read several times per second.A wireless communication module allows remote monitoring of multiple devices in real time.These features allow easy assembly of multiple readers to create a scalable, accurate solution for high-throughput phenotypic screening.

View Article: PubMed Central - PubMed

Affiliation: Department of Biomedical Engineering, University of Virginia, Charlottesville, VA, USA Biology Department, Boston College, Chestnut Hill, MA, USA.

Show MeSH
Related in: MedlinePlus