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Preferential recruitment of Th17 cells to cervical cancer via CCR6-CCL20 pathway.

Yu Q, Lou XM, He Y - PLoS ONE (2015)

Bottom Line: However, the source of the increased tumor-infiltrating Th17 cells remains poorly understood.We investigated the prevalence, phenotype and trafficking property of Th17 cells in patients with cervical cancer.In conclusion, Th17 cells are recruited into tumor tissues preferentially through CCR6-CCL20 pathway, which can serve as a novel therapeutic target for cervical cancer.

View Article: PubMed Central - PubMed

Affiliation: Department of Obstetrics and Gynecology, Hangzhou Obstetrics and Gynecology Hospital, Hangzhou First People's Hospital, Hangzhou, China.

ABSTRACT
Our previous studies suggest that Th17 cells accumulate within tumor tissues and correlate with recurrence of cervical cancer patients. However, the source of the increased tumor-infiltrating Th17 cells remains poorly understood. We investigated the prevalence, phenotype and trafficking property of Th17 cells in patients with cervical cancer. Our results showed that Th17 cells highly aggregated within tumor tissues in an activated phenotype with markedly increased expression of CCR6. Correspondingly, level of CCL20 in the tumor tissues was significantly higher than that in non-tumor and normal control tissues, and strongly positively associated with Th17 cells. Further, in vitro migration assay showed CCL20 had effective chemotaxis to circulating Th17 cells. In conclusion, Th17 cells are recruited into tumor tissues preferentially through CCR6-CCL20 pathway, which can serve as a novel therapeutic target for cervical cancer.

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Association of intratumoral Th17-cell prevalence with clinical parameters.
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pone.0120855.g002: Association of intratumoral Th17-cell prevalence with clinical parameters.

Mentions: Furthermore, the prevalence of Th17 cells was higher in advanced stage tumors than that in early stage tumors (8.12 ± 1.31% in FIGO I vs. 14.18 ± 2.78% in FIGO II vs. 15.50 ±1.73 in FIGO III; Fig. 2). However, there were no significant differences in the prevalence of Th17 cells for age, HPV status, tumor size, infiltration depth, lymph node status, lymph-vascular space invasion and tumor differentiation (Fig. 2).


Preferential recruitment of Th17 cells to cervical cancer via CCR6-CCL20 pathway.

Yu Q, Lou XM, He Y - PLoS ONE (2015)

Association of intratumoral Th17-cell prevalence with clinical parameters.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4359139&req=5

pone.0120855.g002: Association of intratumoral Th17-cell prevalence with clinical parameters.
Mentions: Furthermore, the prevalence of Th17 cells was higher in advanced stage tumors than that in early stage tumors (8.12 ± 1.31% in FIGO I vs. 14.18 ± 2.78% in FIGO II vs. 15.50 ±1.73 in FIGO III; Fig. 2). However, there were no significant differences in the prevalence of Th17 cells for age, HPV status, tumor size, infiltration depth, lymph node status, lymph-vascular space invasion and tumor differentiation (Fig. 2).

Bottom Line: However, the source of the increased tumor-infiltrating Th17 cells remains poorly understood.We investigated the prevalence, phenotype and trafficking property of Th17 cells in patients with cervical cancer.In conclusion, Th17 cells are recruited into tumor tissues preferentially through CCR6-CCL20 pathway, which can serve as a novel therapeutic target for cervical cancer.

View Article: PubMed Central - PubMed

Affiliation: Department of Obstetrics and Gynecology, Hangzhou Obstetrics and Gynecology Hospital, Hangzhou First People's Hospital, Hangzhou, China.

ABSTRACT
Our previous studies suggest that Th17 cells accumulate within tumor tissues and correlate with recurrence of cervical cancer patients. However, the source of the increased tumor-infiltrating Th17 cells remains poorly understood. We investigated the prevalence, phenotype and trafficking property of Th17 cells in patients with cervical cancer. Our results showed that Th17 cells highly aggregated within tumor tissues in an activated phenotype with markedly increased expression of CCR6. Correspondingly, level of CCL20 in the tumor tissues was significantly higher than that in non-tumor and normal control tissues, and strongly positively associated with Th17 cells. Further, in vitro migration assay showed CCL20 had effective chemotaxis to circulating Th17 cells. In conclusion, Th17 cells are recruited into tumor tissues preferentially through CCR6-CCL20 pathway, which can serve as a novel therapeutic target for cervical cancer.

Show MeSH
Related in: MedlinePlus