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Increased plasma levels of heat shock protein 70 associated with subsequent clinical conversion to mild cognitive impairment in cognitively healthy elderly.

Son SJ, Lee KS, Chung JH, Chang KJ, Roh HW, Kim SH, Jin T, Back JH, Kim HJ, Lee Y, Choi SH, Noh JS, Lim KY, Chung YK, Hong CH, Oh BH - PLoS ONE (2015)

Bottom Line: Heat shock proteins (HSPs) have been regarded as cytoprotectants that protect brain cells during the progression of neurodegenerative diseases and from damage resulting from cerebral ischemia.Among participants in the community-based cohort study of dementia called the Gwangju Dementia and Mild Cognitive Impairment Study, subjects without cognitive impairment at baseline, who then either remained without impairment (non-conversion group), or suffered mild cognitive impairment (MCI) (conversion group) (non-conversion group, N = 36; conversion group, N = 30) were analyzed.After a five to six year follow-up period, comparison of the plasma HSP 70 and HSP 27 levels of the two groups revealed that only the plasma HSP 70 level was associated with a conversion to MCI after adjustments for age, gender, years of education, follow-up duration, APOE e4, hypertension, and diabetes (repeated measure analysis of variance: F = 7.59, p = 0.008).

View Article: PubMed Central - PubMed

Affiliation: Department of Psychiatry, Ajou University School of Medicine, 164 Worldcup-ro, Yeongtong-gu, Suwon-si, Gyeonggi-do 443-380, Republic of Korea.

ABSTRACT

Background and aims: Heat shock proteins (HSPs) have been regarded as cytoprotectants that protect brain cells during the progression of neurodegenerative diseases and from damage resulting from cerebral ischemia. In this study, we assessed the association between plasma HSP 70/27 levels and cognitive decline.

Methods: Among participants in the community-based cohort study of dementia called the Gwangju Dementia and Mild Cognitive Impairment Study, subjects without cognitive impairment at baseline, who then either remained without impairment (non-conversion group), or suffered mild cognitive impairment (MCI) (conversion group) (non-conversion group, N = 36; conversion group, N = 30) were analyzed.

Results: After a five to six year follow-up period, comparison of the plasma HSP 70 and HSP 27 levels of the two groups revealed that only the plasma HSP 70 level was associated with a conversion to MCI after adjustments for age, gender, years of education, follow-up duration, APOE e4, hypertension, and diabetes (repeated measure analysis of variance: F = 7.59, p = 0.008). Furthermore, an increase in plasma HSP 70 level was associated with cognitive decline in language and executive function (linear mixed model: Korean Boston Naming Test, -0.426 [-0.781, -0.071], p = 0.019; Controlled Oral Word Association Test, -0.176 [-0.328, -0.023], p = 0.024; Stroop Test, -0.304 [-0.458, -0.150], p<0.001).

Conclusions: These findings suggest that the plasma HSP 70 level may be related to cognitive decline in the elderly.

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Related in: MedlinePlus

Interactive effects between time and group on change in plasma HSP levels.Repeated measure ANOVA was tested. Adjusted for age, gender, years of education, follow-up duration, APOE e4, hypertension, and diabetes (HSP70: F = 7.59 p = 0.008; HSP27: F = 0.67, p = 0.416). * p = 0.008.
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pone.0119180.g001: Interactive effects between time and group on change in plasma HSP levels.Repeated measure ANOVA was tested. Adjusted for age, gender, years of education, follow-up duration, APOE e4, hypertension, and diabetes (HSP70: F = 7.59 p = 0.008; HSP27: F = 0.67, p = 0.416). * p = 0.008.

Mentions: Using repeated measure ANOVA, the interactive effects between the group and time on the change in plasma HSPs levels were tested after adjusting for confounding variables. We observed that plasma HSPs levels tended to increase with age, even though the change was not statistically significant (HSP 70: F = 0.07, p = 0.792; HSP 27: F = 0.25, p = 0.622). However, when considering the effect of the different groups, a significant interaction between group and time was observed in the plasma HSP 70 level (HSP 70: F = 7.59, p = 0.008; HSP 27: F = 0.67, p = 0.416) (Fig. 1).


Increased plasma levels of heat shock protein 70 associated with subsequent clinical conversion to mild cognitive impairment in cognitively healthy elderly.

Son SJ, Lee KS, Chung JH, Chang KJ, Roh HW, Kim SH, Jin T, Back JH, Kim HJ, Lee Y, Choi SH, Noh JS, Lim KY, Chung YK, Hong CH, Oh BH - PLoS ONE (2015)

Interactive effects between time and group on change in plasma HSP levels.Repeated measure ANOVA was tested. Adjusted for age, gender, years of education, follow-up duration, APOE e4, hypertension, and diabetes (HSP70: F = 7.59 p = 0.008; HSP27: F = 0.67, p = 0.416). * p = 0.008.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4359110&req=5

pone.0119180.g001: Interactive effects between time and group on change in plasma HSP levels.Repeated measure ANOVA was tested. Adjusted for age, gender, years of education, follow-up duration, APOE e4, hypertension, and diabetes (HSP70: F = 7.59 p = 0.008; HSP27: F = 0.67, p = 0.416). * p = 0.008.
Mentions: Using repeated measure ANOVA, the interactive effects between the group and time on the change in plasma HSPs levels were tested after adjusting for confounding variables. We observed that plasma HSPs levels tended to increase with age, even though the change was not statistically significant (HSP 70: F = 0.07, p = 0.792; HSP 27: F = 0.25, p = 0.622). However, when considering the effect of the different groups, a significant interaction between group and time was observed in the plasma HSP 70 level (HSP 70: F = 7.59, p = 0.008; HSP 27: F = 0.67, p = 0.416) (Fig. 1).

Bottom Line: Heat shock proteins (HSPs) have been regarded as cytoprotectants that protect brain cells during the progression of neurodegenerative diseases and from damage resulting from cerebral ischemia.Among participants in the community-based cohort study of dementia called the Gwangju Dementia and Mild Cognitive Impairment Study, subjects without cognitive impairment at baseline, who then either remained without impairment (non-conversion group), or suffered mild cognitive impairment (MCI) (conversion group) (non-conversion group, N = 36; conversion group, N = 30) were analyzed.After a five to six year follow-up period, comparison of the plasma HSP 70 and HSP 27 levels of the two groups revealed that only the plasma HSP 70 level was associated with a conversion to MCI after adjustments for age, gender, years of education, follow-up duration, APOE e4, hypertension, and diabetes (repeated measure analysis of variance: F = 7.59, p = 0.008).

View Article: PubMed Central - PubMed

Affiliation: Department of Psychiatry, Ajou University School of Medicine, 164 Worldcup-ro, Yeongtong-gu, Suwon-si, Gyeonggi-do 443-380, Republic of Korea.

ABSTRACT

Background and aims: Heat shock proteins (HSPs) have been regarded as cytoprotectants that protect brain cells during the progression of neurodegenerative diseases and from damage resulting from cerebral ischemia. In this study, we assessed the association between plasma HSP 70/27 levels and cognitive decline.

Methods: Among participants in the community-based cohort study of dementia called the Gwangju Dementia and Mild Cognitive Impairment Study, subjects without cognitive impairment at baseline, who then either remained without impairment (non-conversion group), or suffered mild cognitive impairment (MCI) (conversion group) (non-conversion group, N = 36; conversion group, N = 30) were analyzed.

Results: After a five to six year follow-up period, comparison of the plasma HSP 70 and HSP 27 levels of the two groups revealed that only the plasma HSP 70 level was associated with a conversion to MCI after adjustments for age, gender, years of education, follow-up duration, APOE e4, hypertension, and diabetes (repeated measure analysis of variance: F = 7.59, p = 0.008). Furthermore, an increase in plasma HSP 70 level was associated with cognitive decline in language and executive function (linear mixed model: Korean Boston Naming Test, -0.426 [-0.781, -0.071], p = 0.019; Controlled Oral Word Association Test, -0.176 [-0.328, -0.023], p = 0.024; Stroop Test, -0.304 [-0.458, -0.150], p<0.001).

Conclusions: These findings suggest that the plasma HSP 70 level may be related to cognitive decline in the elderly.

Show MeSH
Related in: MedlinePlus