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Randomized trial of complete versus lesion-only revascularization in patients undergoing primary percutaneous coronary intervention for STEMI and multivessel disease: the CvLPRIT trial.

Gershlick AH, Khan JN, Kelly DJ, Greenwood JP, Sasikaran T, Curzen N, Blackman DJ, Dalby M, Fairbrother KL, Banya W, Wang D, Flather M, Hetherington SL, Kelion AD, Talwar S, Gunning M, Hall R, Swanton H, McCann GP - J. Am. Coll. Cardiol. (2015)

Bottom Line: Patient groups were well matched for baseline clinical characteristics.Although there was no significant reduction in death or MI, a nonsignificant reduction in all primary endpoint components was seen.There was no reduction in ischemic burden on myocardial perfusion scintigraphy or in the safety endpoints of major bleeding, contrast-induced nephropathy, or stroke between the groups.

View Article: PubMed Central - PubMed

Affiliation: Department of Cardiovascular Sciences, University of Leicester and National Institute of Health Research Leicester Cardiovascular Biomedical Research Unit, Glenfield Hospital, Leicester, United Kingdom. Electronic address: agershlick@aol.com.

No MeSH data available.


Related in: MedlinePlus

Kaplan-Meier CurvesCumulative event rate for IRA-only versus complete revascularization groups. CI = confidence interval; other abbreviations as in Figure 1.
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Related In: Results  -  Collection


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fig3: Kaplan-Meier CurvesCumulative event rate for IRA-only versus complete revascularization groups. CI = confidence interval; other abbreviations as in Figure 1.

Mentions: The primary endpoint is presented as time to first event (Table 3). MACE was significantly lower in the complete revascularization arm (10.0%) than in the IRA-only arm (21.2%; hazard ratio: 0.45; 95% confidence interval: 0.24 to 0.84; p = 0.009). The individual components of the primary endpoint and cardiovascular mortality were all also lower, although none were statistically significant. The Kaplan-Meier curves (Figure 2) showed early divergence, with continuing separation during follow-up. The forest plot for pre-specified subanalyses is shown in Online Figure 1. Kaplan-Meier curves to 30 days are shown in Online Figure 2.


Randomized trial of complete versus lesion-only revascularization in patients undergoing primary percutaneous coronary intervention for STEMI and multivessel disease: the CvLPRIT trial.

Gershlick AH, Khan JN, Kelly DJ, Greenwood JP, Sasikaran T, Curzen N, Blackman DJ, Dalby M, Fairbrother KL, Banya W, Wang D, Flather M, Hetherington SL, Kelion AD, Talwar S, Gunning M, Hall R, Swanton H, McCann GP - J. Am. Coll. Cardiol. (2015)

Kaplan-Meier CurvesCumulative event rate for IRA-only versus complete revascularization groups. CI = confidence interval; other abbreviations as in Figure 1.
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4359051&req=5

fig3: Kaplan-Meier CurvesCumulative event rate for IRA-only versus complete revascularization groups. CI = confidence interval; other abbreviations as in Figure 1.
Mentions: The primary endpoint is presented as time to first event (Table 3). MACE was significantly lower in the complete revascularization arm (10.0%) than in the IRA-only arm (21.2%; hazard ratio: 0.45; 95% confidence interval: 0.24 to 0.84; p = 0.009). The individual components of the primary endpoint and cardiovascular mortality were all also lower, although none were statistically significant. The Kaplan-Meier curves (Figure 2) showed early divergence, with continuing separation during follow-up. The forest plot for pre-specified subanalyses is shown in Online Figure 1. Kaplan-Meier curves to 30 days are shown in Online Figure 2.

Bottom Line: Patient groups were well matched for baseline clinical characteristics.Although there was no significant reduction in death or MI, a nonsignificant reduction in all primary endpoint components was seen.There was no reduction in ischemic burden on myocardial perfusion scintigraphy or in the safety endpoints of major bleeding, contrast-induced nephropathy, or stroke between the groups.

View Article: PubMed Central - PubMed

Affiliation: Department of Cardiovascular Sciences, University of Leicester and National Institute of Health Research Leicester Cardiovascular Biomedical Research Unit, Glenfield Hospital, Leicester, United Kingdom. Electronic address: agershlick@aol.com.

No MeSH data available.


Related in: MedlinePlus