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Clinical relevance of Küttner tumour and IgG4-related dacryoadenitis and sialoadenitis.

Furukawa S, Moriyama M, Kawano S, Tanaka A, Maehara T, Hayashida JN, Goto Y, Kiyoshima T, Shiratsuchi H, Ohyama Y, Ohta M, Imabayashi Y, Nakamura S - Oral Dis (2014)

Bottom Line: The aim of this study was to clarify the clinical and pathological associations between KT and IgG4-DS.There were no significant differences in the clinical findings, including the mean age, sex and disease duration, between the two groups.These results suggest an association between the pathogeneses of KT-S (-) and IgG4-DS, but not KT-S (+).

View Article: PubMed Central - PubMed

Affiliation: Section of Oral and Maxillofacial Oncology, Division of Maxillofacial Diagnostic and Surgical Sciences, Faculty of Dental Science, Kyushu University, Fukuoka, Japan.

No MeSH data available.


Related in: MedlinePlus

IgG4 production of patients with Küttner tumour (KT)-S (+) and KT-S (−). HPF, high-power field. The bar shows the mean value ± standard deviation (s.d.). *P < 0.05, **P < 0.01 (Mann–Whitney U-test)
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fig03: IgG4 production of patients with Küttner tumour (KT)-S (+) and KT-S (−). HPF, high-power field. The bar shows the mean value ± standard deviation (s.d.). *P < 0.05, **P < 0.01 (Mann–Whitney U-test)

Mentions: Representative sialographic findings in the SMGs of both KT-S (+) and KT-S (−) patients are shown in Figure2. KT-S (+) showed strong non-IgG4 lymphocytic infiltration and severe widespread fibrosis. Seven of the eight KT-S (−) patients showed selective infiltration of IgG4-positive cells [IgG4-positive cells/IgG-positive cells >0.4 based on ‘Diagnostic criteria for IgG4-related Mikulicz's disease’ (Umehara et al, 2012b)] and severe cordlike fibrosis with formation of ectopic germinal centres (eGCs). In contrast, one of the eight KT-S (−) patients showed moderate widespread fibrosis and diffuse lymphocytic infiltration without eGCs and a very small number of IgG-positive and IgG4-positive cells. The frequency and number of IgG4-positive cells in the SMGs of KT-S (−) patients were significantly higher than those of KT-S (+) patients (Figure3).


Clinical relevance of Küttner tumour and IgG4-related dacryoadenitis and sialoadenitis.

Furukawa S, Moriyama M, Kawano S, Tanaka A, Maehara T, Hayashida JN, Goto Y, Kiyoshima T, Shiratsuchi H, Ohyama Y, Ohta M, Imabayashi Y, Nakamura S - Oral Dis (2014)

IgG4 production of patients with Küttner tumour (KT)-S (+) and KT-S (−). HPF, high-power field. The bar shows the mean value ± standard deviation (s.d.). *P < 0.05, **P < 0.01 (Mann–Whitney U-test)
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4359042&req=5

fig03: IgG4 production of patients with Küttner tumour (KT)-S (+) and KT-S (−). HPF, high-power field. The bar shows the mean value ± standard deviation (s.d.). *P < 0.05, **P < 0.01 (Mann–Whitney U-test)
Mentions: Representative sialographic findings in the SMGs of both KT-S (+) and KT-S (−) patients are shown in Figure2. KT-S (+) showed strong non-IgG4 lymphocytic infiltration and severe widespread fibrosis. Seven of the eight KT-S (−) patients showed selective infiltration of IgG4-positive cells [IgG4-positive cells/IgG-positive cells >0.4 based on ‘Diagnostic criteria for IgG4-related Mikulicz's disease’ (Umehara et al, 2012b)] and severe cordlike fibrosis with formation of ectopic germinal centres (eGCs). In contrast, one of the eight KT-S (−) patients showed moderate widespread fibrosis and diffuse lymphocytic infiltration without eGCs and a very small number of IgG-positive and IgG4-positive cells. The frequency and number of IgG4-positive cells in the SMGs of KT-S (−) patients were significantly higher than those of KT-S (+) patients (Figure3).

Bottom Line: The aim of this study was to clarify the clinical and pathological associations between KT and IgG4-DS.There were no significant differences in the clinical findings, including the mean age, sex and disease duration, between the two groups.These results suggest an association between the pathogeneses of KT-S (-) and IgG4-DS, but not KT-S (+).

View Article: PubMed Central - PubMed

Affiliation: Section of Oral and Maxillofacial Oncology, Division of Maxillofacial Diagnostic and Surgical Sciences, Faculty of Dental Science, Kyushu University, Fukuoka, Japan.

No MeSH data available.


Related in: MedlinePlus