Limits...
Clinical relevance of Küttner tumour and IgG4-related dacryoadenitis and sialoadenitis.

Furukawa S, Moriyama M, Kawano S, Tanaka A, Maehara T, Hayashida JN, Goto Y, Kiyoshima T, Shiratsuchi H, Ohyama Y, Ohta M, Imabayashi Y, Nakamura S - Oral Dis (2014)

Bottom Line: The aim of this study was to clarify the clinical and pathological associations between KT and IgG4-DS.There were no significant differences in the clinical findings, including the mean age, sex and disease duration, between the two groups.These results suggest an association between the pathogeneses of KT-S (-) and IgG4-DS, but not KT-S (+).

View Article: PubMed Central - PubMed

Affiliation: Section of Oral and Maxillofacial Oncology, Division of Maxillofacial Diagnostic and Surgical Sciences, Faculty of Dental Science, Kyushu University, Fukuoka, Japan.

No MeSH data available.


Related in: MedlinePlus

Histological findings in submandibular glands of patients with CS. IgG4 (+), IgG4-positive plasma cells/IgG-positive plasma cells >0.4; IgG4 (−), IgG4-positive plasma cells/IgG-positive plasma cells ≤0.4; MT, Masson's trichrome staining; Scale bars, 400 μm
© Copyright Policy - open-access
Related In: Results  -  Collection

License
getmorefigures.php?uid=PMC4359042&req=5

fig02: Histological findings in submandibular glands of patients with CS. IgG4 (+), IgG4-positive plasma cells/IgG-positive plasma cells >0.4; IgG4 (−), IgG4-positive plasma cells/IgG-positive plasma cells ≤0.4; MT, Masson's trichrome staining; Scale bars, 400 μm

Mentions: Representative sialographic findings in the SMGs of both KT-S (+) and KT-S (−) patients are shown in Figure2. KT-S (+) showed strong non-IgG4 lymphocytic infiltration and severe widespread fibrosis. Seven of the eight KT-S (−) patients showed selective infiltration of IgG4-positive cells [IgG4-positive cells/IgG-positive cells >0.4 based on ‘Diagnostic criteria for IgG4-related Mikulicz's disease’ (Umehara et al, 2012b)] and severe cordlike fibrosis with formation of ectopic germinal centres (eGCs). In contrast, one of the eight KT-S (−) patients showed moderate widespread fibrosis and diffuse lymphocytic infiltration without eGCs and a very small number of IgG-positive and IgG4-positive cells. The frequency and number of IgG4-positive cells in the SMGs of KT-S (−) patients were significantly higher than those of KT-S (+) patients (Figure3).


Clinical relevance of Küttner tumour and IgG4-related dacryoadenitis and sialoadenitis.

Furukawa S, Moriyama M, Kawano S, Tanaka A, Maehara T, Hayashida JN, Goto Y, Kiyoshima T, Shiratsuchi H, Ohyama Y, Ohta M, Imabayashi Y, Nakamura S - Oral Dis (2014)

Histological findings in submandibular glands of patients with CS. IgG4 (+), IgG4-positive plasma cells/IgG-positive plasma cells >0.4; IgG4 (−), IgG4-positive plasma cells/IgG-positive plasma cells ≤0.4; MT, Masson's trichrome staining; Scale bars, 400 μm
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4359042&req=5

fig02: Histological findings in submandibular glands of patients with CS. IgG4 (+), IgG4-positive plasma cells/IgG-positive plasma cells >0.4; IgG4 (−), IgG4-positive plasma cells/IgG-positive plasma cells ≤0.4; MT, Masson's trichrome staining; Scale bars, 400 μm
Mentions: Representative sialographic findings in the SMGs of both KT-S (+) and KT-S (−) patients are shown in Figure2. KT-S (+) showed strong non-IgG4 lymphocytic infiltration and severe widespread fibrosis. Seven of the eight KT-S (−) patients showed selective infiltration of IgG4-positive cells [IgG4-positive cells/IgG-positive cells >0.4 based on ‘Diagnostic criteria for IgG4-related Mikulicz's disease’ (Umehara et al, 2012b)] and severe cordlike fibrosis with formation of ectopic germinal centres (eGCs). In contrast, one of the eight KT-S (−) patients showed moderate widespread fibrosis and diffuse lymphocytic infiltration without eGCs and a very small number of IgG-positive and IgG4-positive cells. The frequency and number of IgG4-positive cells in the SMGs of KT-S (−) patients were significantly higher than those of KT-S (+) patients (Figure3).

Bottom Line: The aim of this study was to clarify the clinical and pathological associations between KT and IgG4-DS.There were no significant differences in the clinical findings, including the mean age, sex and disease duration, between the two groups.These results suggest an association between the pathogeneses of KT-S (-) and IgG4-DS, but not KT-S (+).

View Article: PubMed Central - PubMed

Affiliation: Section of Oral and Maxillofacial Oncology, Division of Maxillofacial Diagnostic and Surgical Sciences, Faculty of Dental Science, Kyushu University, Fukuoka, Japan.

No MeSH data available.


Related in: MedlinePlus