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Circulating level of CTRP1 in patients with nonalcoholic fatty liver disease (NAFLD): is it through insulin resistance?

Shabani P, Naeimi Khaledi H, Beigy M, Emamgholipour S, Parvaz E, Poustchi H, Doosti M - PLoS ONE (2015)

Bottom Line: Plasma concentration of CTRP1 in patients with NAFLD, T2DM and NAFLD+T2DM were significantly higher than healthy subjects (p<0.0001).Our results indicate the strong association of CTRP1 with insulin resistance in NAFLD.Also, it seems that CTRP1 can be considered as an emerging biomarker for NAFLD, however, more studies are necessary to unravel the role of CTRP1 in NAFLD pathogenesis.

View Article: PubMed Central - PubMed

Affiliation: Department of Biochemistry, Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran.

ABSTRACT
Nonalcoholic fatty liver disease (NAFLD) is considered as one of the most common liver diseases. It is robustly linked to obesity and insulin resistance and is regarded as hepatic manifestation of metabolic syndrome (MetS). Adipokines are involved in the pathophysiology of liver diseases. The aim of this study was to evaluate the plasma concentrations of CTRP1 (complement-C1q TNF-related protein 1) in 22 patients with NAFLD, 22 patients with type 2 diabetes mellitus (T2DM), 22 patients with NAFLD+T2DM and 21 healthy controls, as well as their correlation with the level of metabolic and hepatic parameters. Plasma concentration of CTRP1 was measured with ELISA method. Plasma concentration of CTRP1 in patients with NAFLD, T2DM and NAFLD+T2DM were significantly higher than healthy subjects (p<0.0001). Moreover, we observed significant positive correlations between plasma level of CTRP1 and fasting blood glucose (FBG) (p<0.001), homeostasis model assessment of insulin resistance (HOMA-IR) (p<0.001), body mass index (BMI) (p = 0.001), alanine amino transferase (ALT) (p = 0.002), gamma glutamyl transferase (γ-GT) (p<0.001) and liver stiffness (LS) (p<0.001). Our results indicate the strong association of CTRP1 with insulin resistance in NAFLD. Also, it seems that CTRP1 can be considered as an emerging biomarker for NAFLD, however, more studies are necessary to unravel the role of CTRP1 in NAFLD pathogenesis.

No MeSH data available.


Related in: MedlinePlus

Significant positive correlations between plasma CTRP1 levels and serum ALT (a), γ-GT (b), LS (c), FBG (d), BMI (e), HOMA-IR (f) were found.Linear regression equation and r square (R2) are displayed at upper left position below the legends of participants’ status.
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pone.0118650.g002: Significant positive correlations between plasma CTRP1 levels and serum ALT (a), γ-GT (b), LS (c), FBG (d), BMI (e), HOMA-IR (f) were found.Linear regression equation and r square (R2) are displayed at upper left position below the legends of participants’ status.

Mentions: Also we assessed the correlation between plasma CTRP1 levels and liver enzymes, liver stiffness and metabolic profile in the whole study population. Plasma CTRP1 level showed a significant positive correlation with serum levels of liver enzymes including ALT and γ-GT (Fig. 2a and 2b). There was also significant positive correlation between plasma level of CTRP1 and liver stiffness (Fig. 2c); furthermore, significant positive correlations were found between plasma CTRP1 levels with BMI, FBG and HOMA-IR (Fig. 2d, 2e and 2f). Subgroup analyses revealed significant positive correlations between plasma level of CTRP1 and FBG in three patient groups, however correlations between plasma level of CTRP1 and liver stiffness was only observed in NAFLD group (Spearman Rho = 0.521; p = 0.011) and there was not a significant correlation between plasma level of CTRP1 and other parameters in subgroups.


Circulating level of CTRP1 in patients with nonalcoholic fatty liver disease (NAFLD): is it through insulin resistance?

Shabani P, Naeimi Khaledi H, Beigy M, Emamgholipour S, Parvaz E, Poustchi H, Doosti M - PLoS ONE (2015)

Significant positive correlations between plasma CTRP1 levels and serum ALT (a), γ-GT (b), LS (c), FBG (d), BMI (e), HOMA-IR (f) were found.Linear regression equation and r square (R2) are displayed at upper left position below the legends of participants’ status.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4358971&req=5

pone.0118650.g002: Significant positive correlations between plasma CTRP1 levels and serum ALT (a), γ-GT (b), LS (c), FBG (d), BMI (e), HOMA-IR (f) were found.Linear regression equation and r square (R2) are displayed at upper left position below the legends of participants’ status.
Mentions: Also we assessed the correlation between plasma CTRP1 levels and liver enzymes, liver stiffness and metabolic profile in the whole study population. Plasma CTRP1 level showed a significant positive correlation with serum levels of liver enzymes including ALT and γ-GT (Fig. 2a and 2b). There was also significant positive correlation between plasma level of CTRP1 and liver stiffness (Fig. 2c); furthermore, significant positive correlations were found between plasma CTRP1 levels with BMI, FBG and HOMA-IR (Fig. 2d, 2e and 2f). Subgroup analyses revealed significant positive correlations between plasma level of CTRP1 and FBG in three patient groups, however correlations between plasma level of CTRP1 and liver stiffness was only observed in NAFLD group (Spearman Rho = 0.521; p = 0.011) and there was not a significant correlation between plasma level of CTRP1 and other parameters in subgroups.

Bottom Line: Plasma concentration of CTRP1 in patients with NAFLD, T2DM and NAFLD+T2DM were significantly higher than healthy subjects (p<0.0001).Our results indicate the strong association of CTRP1 with insulin resistance in NAFLD.Also, it seems that CTRP1 can be considered as an emerging biomarker for NAFLD, however, more studies are necessary to unravel the role of CTRP1 in NAFLD pathogenesis.

View Article: PubMed Central - PubMed

Affiliation: Department of Biochemistry, Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran.

ABSTRACT
Nonalcoholic fatty liver disease (NAFLD) is considered as one of the most common liver diseases. It is robustly linked to obesity and insulin resistance and is regarded as hepatic manifestation of metabolic syndrome (MetS). Adipokines are involved in the pathophysiology of liver diseases. The aim of this study was to evaluate the plasma concentrations of CTRP1 (complement-C1q TNF-related protein 1) in 22 patients with NAFLD, 22 patients with type 2 diabetes mellitus (T2DM), 22 patients with NAFLD+T2DM and 21 healthy controls, as well as their correlation with the level of metabolic and hepatic parameters. Plasma concentration of CTRP1 was measured with ELISA method. Plasma concentration of CTRP1 in patients with NAFLD, T2DM and NAFLD+T2DM were significantly higher than healthy subjects (p<0.0001). Moreover, we observed significant positive correlations between plasma level of CTRP1 and fasting blood glucose (FBG) (p<0.001), homeostasis model assessment of insulin resistance (HOMA-IR) (p<0.001), body mass index (BMI) (p = 0.001), alanine amino transferase (ALT) (p = 0.002), gamma glutamyl transferase (γ-GT) (p<0.001) and liver stiffness (LS) (p<0.001). Our results indicate the strong association of CTRP1 with insulin resistance in NAFLD. Also, it seems that CTRP1 can be considered as an emerging biomarker for NAFLD, however, more studies are necessary to unravel the role of CTRP1 in NAFLD pathogenesis.

No MeSH data available.


Related in: MedlinePlus