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The comparison of surgical patients with primary hepatic squamous cell carcinoma or adenosquamous carcinoma and surgical patients with hepatocellular carcinoma.

Yan L, Xie F, Yang C, Yu L, Zheng T, Fu J, Yang J - World J Surg Oncol (2015)

Bottom Line: Serum tumor markers showed significant differences between primary hepatic SCC/ASC and HCC patients, especially for serum alpha fetal protein (AFP) level and carbohydrate antigen 19-9 (CA 19-9).Significant difference was not discovered when SCC and ASC patients were compared with HCC patients (P = 0.294).And the treatment of liver resection was effective for those patients who met the selection criteria for liver resection.

View Article: PubMed Central - PubMed

Affiliation: Department of Special Treatment and Liver Transplantation, Eastern Hepatobiliary Hospital, the Second Military Medical University, 255 Changhai Road, Shanghai, 200438, China. hunanxiefeng@yahoo.com.cn.

ABSTRACT

Background: There are still several controversies and ambiguities in the aspects of primary hepatic squamous cell carcinoma and primary hepatic adenosquamous carcinoma. To further clarify the specific features of these two infrequent diseases and provide beneficial propose for clinical decision, we did this retrospective study.

Methods: We reviewed the clinical features and outcomes of three primary hepatic squamous cell carcinoma (SCC) patients and six primary hepatic adenosquamous carcinoma (ASC) patients from January 1998 to December 2011 in Eastern Hepatobiliary Surgery Hospital in China. Meanwhile, 40 hepatocellular carcinoma (HCC) patients and 26 metastatic hepatic SCC or ASC patients who were hospitalized in the same period were also reviewed to make a comparison. In order to find out the definite survival information of SCC and ASC patients, 30 previous studies containing 37 primary hepatic SCC (16) and ASC (21) patients were reviewed, and their information of survival was analyzed together with the included patients in our hospital.

Results: Serum tumor markers showed significant differences between primary hepatic SCC/ASC and HCC patients, especially for serum alpha fetal protein (AFP) level and carbohydrate antigen 19-9 (CA 19-9). On the pathologic performance, primary SCC/ASC tumor was rarely accompanied with tumor capsule. They presented peripheral hepatic lymph node metastasis more likely and showed low proportion of microvascular invasion. The median survival time of primary hepatic SCC/ASC patients after liver resection (LR) was 15 months. And the 1-, 3-, 5-year survival rates after LR were 60%, 24%, and 12%, respectively. Significant difference was not discovered when SCC and ASC patients were compared with HCC patients (P = 0.294). The median survival time after LR for primary SCC and ASC patients was respectively 23 months and 13 months.

Conclusions: The comprehensive application of some clinical characteristics, histopathologic features, and imaging findings may be useful for us in making definite diagnoses for primary hepatic SCC and ASC patients preoperatively. And the treatment of liver resection was effective for those patients who met the selection criteria for liver resection.

No MeSH data available.


Related in: MedlinePlus

Two typical HE tumor tissue slices.(A) The squamous cancer cells were polygonal and arranged as strips, and their nucleuses were round or orbicular-ovate, most of which even had pathologic change, like karyomegaly and anachromasis (H & E stain, ×200). (B) Except the performance of squamous cell carcinoma components, adenocarcinoma cells were cubic or columnar and arranged like glandular tube (H & E stain, ×200).
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Fig1: Two typical HE tumor tissue slices.(A) The squamous cancer cells were polygonal and arranged as strips, and their nucleuses were round or orbicular-ovate, most of which even had pathologic change, like karyomegaly and anachromasis (H & E stain, ×200). (B) Except the performance of squamous cell carcinoma components, adenocarcinoma cells were cubic or columnar and arranged like glandular tube (H & E stain, ×200).

Mentions: Microscopically, the postoperative tumor tissue slice of primary hepatic SCC presented that the cancer cells were polygonal and arranged as strips, and their nucleuses were round or orbicular-ovate, most of which even had pathologic change, like karyomegaly and anachromasis. No capsule was found around the tumor and it appeared multifocal growth. Apart from the performance of squamous cancer cells, the tumor tissue of primary hepatic ASC arranged like glandular tube, adenocarcinoma cells were cubic or columnar and the tumor appeared infiltrative growth. We chose two typical HE tumor tissue slices from the nine primary carcinoma patients (Figure 1), of whom one was primary SCC (A), and the other was ASC (B).Figure 1


The comparison of surgical patients with primary hepatic squamous cell carcinoma or adenosquamous carcinoma and surgical patients with hepatocellular carcinoma.

Yan L, Xie F, Yang C, Yu L, Zheng T, Fu J, Yang J - World J Surg Oncol (2015)

Two typical HE tumor tissue slices.(A) The squamous cancer cells were polygonal and arranged as strips, and their nucleuses were round or orbicular-ovate, most of which even had pathologic change, like karyomegaly and anachromasis (H & E stain, ×200). (B) Except the performance of squamous cell carcinoma components, adenocarcinoma cells were cubic or columnar and arranged like glandular tube (H & E stain, ×200).
© Copyright Policy - open-access
Related In: Results  -  Collection

License 1 - License 2
Show All Figures
getmorefigures.php?uid=PMC4358902&req=5

Fig1: Two typical HE tumor tissue slices.(A) The squamous cancer cells were polygonal and arranged as strips, and their nucleuses were round or orbicular-ovate, most of which even had pathologic change, like karyomegaly and anachromasis (H & E stain, ×200). (B) Except the performance of squamous cell carcinoma components, adenocarcinoma cells were cubic or columnar and arranged like glandular tube (H & E stain, ×200).
Mentions: Microscopically, the postoperative tumor tissue slice of primary hepatic SCC presented that the cancer cells were polygonal and arranged as strips, and their nucleuses were round or orbicular-ovate, most of which even had pathologic change, like karyomegaly and anachromasis. No capsule was found around the tumor and it appeared multifocal growth. Apart from the performance of squamous cancer cells, the tumor tissue of primary hepatic ASC arranged like glandular tube, adenocarcinoma cells were cubic or columnar and the tumor appeared infiltrative growth. We chose two typical HE tumor tissue slices from the nine primary carcinoma patients (Figure 1), of whom one was primary SCC (A), and the other was ASC (B).Figure 1

Bottom Line: Serum tumor markers showed significant differences between primary hepatic SCC/ASC and HCC patients, especially for serum alpha fetal protein (AFP) level and carbohydrate antigen 19-9 (CA 19-9).Significant difference was not discovered when SCC and ASC patients were compared with HCC patients (P = 0.294).And the treatment of liver resection was effective for those patients who met the selection criteria for liver resection.

View Article: PubMed Central - PubMed

Affiliation: Department of Special Treatment and Liver Transplantation, Eastern Hepatobiliary Hospital, the Second Military Medical University, 255 Changhai Road, Shanghai, 200438, China. hunanxiefeng@yahoo.com.cn.

ABSTRACT

Background: There are still several controversies and ambiguities in the aspects of primary hepatic squamous cell carcinoma and primary hepatic adenosquamous carcinoma. To further clarify the specific features of these two infrequent diseases and provide beneficial propose for clinical decision, we did this retrospective study.

Methods: We reviewed the clinical features and outcomes of three primary hepatic squamous cell carcinoma (SCC) patients and six primary hepatic adenosquamous carcinoma (ASC) patients from January 1998 to December 2011 in Eastern Hepatobiliary Surgery Hospital in China. Meanwhile, 40 hepatocellular carcinoma (HCC) patients and 26 metastatic hepatic SCC or ASC patients who were hospitalized in the same period were also reviewed to make a comparison. In order to find out the definite survival information of SCC and ASC patients, 30 previous studies containing 37 primary hepatic SCC (16) and ASC (21) patients were reviewed, and their information of survival was analyzed together with the included patients in our hospital.

Results: Serum tumor markers showed significant differences between primary hepatic SCC/ASC and HCC patients, especially for serum alpha fetal protein (AFP) level and carbohydrate antigen 19-9 (CA 19-9). On the pathologic performance, primary SCC/ASC tumor was rarely accompanied with tumor capsule. They presented peripheral hepatic lymph node metastasis more likely and showed low proportion of microvascular invasion. The median survival time of primary hepatic SCC/ASC patients after liver resection (LR) was 15 months. And the 1-, 3-, 5-year survival rates after LR were 60%, 24%, and 12%, respectively. Significant difference was not discovered when SCC and ASC patients were compared with HCC patients (P = 0.294). The median survival time after LR for primary SCC and ASC patients was respectively 23 months and 13 months.

Conclusions: The comprehensive application of some clinical characteristics, histopathologic features, and imaging findings may be useful for us in making definite diagnoses for primary hepatic SCC and ASC patients preoperatively. And the treatment of liver resection was effective for those patients who met the selection criteria for liver resection.

No MeSH data available.


Related in: MedlinePlus