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Complete blood count reference intervals for healthy Han Chinese adults.

Wu X, Zhao M, Pan B, Zhang J, Peng M, Wang L, Hao X, Huang X, Mu R, Guo W, Qiao R, Chen W, Jiang H, Ma Y, Shang H - PLoS ONE (2015)

Bottom Line: Median and mean platelet counts from the Chengdu center were significantly lower than those from other centers.Other CBC parameters showed no significant instrument-, region-, age-, or sex-dependent difference.The reference interval for platelets for the Chengdu center should be established independently.

View Article: PubMed Central - PubMed

Affiliation: Department of Laboratory Science, the Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangdong, China.

ABSTRACT

Background: Complete blood count (CBC) reference intervals are important to diagnose diseases, screen blood donors, and assess overall health. However, current reference intervals established by older instruments and technologies and those from American and European populations are not suitable for Chinese samples due to ethnic, dietary, and lifestyle differences. The aim of this multicenter collaborative study was to establish CBC reference intervals for healthy Han Chinese adults.

Methods: A total of 4,642 healthy individuals (2,136 males and 2,506 females) were recruited from six clinical centers in China (Shenyang, Beijing, Shanghai, Guangzhou, Chengdu, and Xi'an). Blood samples collected in K2EDTA anticoagulant tubes were analyzed. Analysis of variance was performed to determine differences in consensus intervals according to the use of data from the combined sample and selected samples.

Results: Median and mean platelet counts from the Chengdu center were significantly lower than those from other centers. Red blood cell count (RBC), hemoglobin (HGB), and hematocrit (HCT) values were higher in males than in females at all ages. Other CBC parameters showed no significant instrument-, region-, age-, or sex-dependent difference. Thalassemia carriers were found to affect the lower or upper limit of different RBC profiles.

Conclusion: We were able to establish consensus intervals for CBC parameters in healthy Han Chinese adults. RBC, HGB, and HCT intervals were established for each sex. The reference interval for platelets for the Chengdu center should be established independently.

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Related in: MedlinePlus

Variations in red blood cell (RBC) profile according to age and sex.(A) RBC, (B) hemoglobin (HGB), (C) hematocrit (HCT), (D) mean corpuscular volume (MCV), (E) mean corpuscular hemoglobin (MCH), (F) MCH concentration (MCHC). *Females show significantly lower values (P < 0.05) than males in the same age group.
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pone.0119669.g003: Variations in red blood cell (RBC) profile according to age and sex.(A) RBC, (B) hemoglobin (HGB), (C) hematocrit (HCT), (D) mean corpuscular volume (MCV), (E) mean corpuscular hemoglobin (MCH), (F) MCH concentration (MCHC). *Females show significantly lower values (P < 0.05) than males in the same age group.

Mentions: Fig. 3A-3C display mean values of RBC, HGB, and HCT according to age and sex. A significant difference between sexes (P < 0.05) and a minor difference among age groups were observed. Thus, RBC, HGB, and HCT data from different age groups were pooled, but the sex distinction was preserved when establishing reference intervals. RBC, HGB, and HCT values tended to decrease with age in males and were obviously reduced in the 70–79 age group, and these values tended to increase slightly with age in females and were lower than values in males in all age groups. Mean values of MCV, MCH, and MCHC did not differ according to age or sex in the combined analysis of all data (Fig. 3D-3F).


Complete blood count reference intervals for healthy Han Chinese adults.

Wu X, Zhao M, Pan B, Zhang J, Peng M, Wang L, Hao X, Huang X, Mu R, Guo W, Qiao R, Chen W, Jiang H, Ma Y, Shang H - PLoS ONE (2015)

Variations in red blood cell (RBC) profile according to age and sex.(A) RBC, (B) hemoglobin (HGB), (C) hematocrit (HCT), (D) mean corpuscular volume (MCV), (E) mean corpuscular hemoglobin (MCH), (F) MCH concentration (MCHC). *Females show significantly lower values (P < 0.05) than males in the same age group.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4358890&req=5

pone.0119669.g003: Variations in red blood cell (RBC) profile according to age and sex.(A) RBC, (B) hemoglobin (HGB), (C) hematocrit (HCT), (D) mean corpuscular volume (MCV), (E) mean corpuscular hemoglobin (MCH), (F) MCH concentration (MCHC). *Females show significantly lower values (P < 0.05) than males in the same age group.
Mentions: Fig. 3A-3C display mean values of RBC, HGB, and HCT according to age and sex. A significant difference between sexes (P < 0.05) and a minor difference among age groups were observed. Thus, RBC, HGB, and HCT data from different age groups were pooled, but the sex distinction was preserved when establishing reference intervals. RBC, HGB, and HCT values tended to decrease with age in males and were obviously reduced in the 70–79 age group, and these values tended to increase slightly with age in females and were lower than values in males in all age groups. Mean values of MCV, MCH, and MCHC did not differ according to age or sex in the combined analysis of all data (Fig. 3D-3F).

Bottom Line: Median and mean platelet counts from the Chengdu center were significantly lower than those from other centers.Other CBC parameters showed no significant instrument-, region-, age-, or sex-dependent difference.The reference interval for platelets for the Chengdu center should be established independently.

View Article: PubMed Central - PubMed

Affiliation: Department of Laboratory Science, the Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangdong, China.

ABSTRACT

Background: Complete blood count (CBC) reference intervals are important to diagnose diseases, screen blood donors, and assess overall health. However, current reference intervals established by older instruments and technologies and those from American and European populations are not suitable for Chinese samples due to ethnic, dietary, and lifestyle differences. The aim of this multicenter collaborative study was to establish CBC reference intervals for healthy Han Chinese adults.

Methods: A total of 4,642 healthy individuals (2,136 males and 2,506 females) were recruited from six clinical centers in China (Shenyang, Beijing, Shanghai, Guangzhou, Chengdu, and Xi'an). Blood samples collected in K2EDTA anticoagulant tubes were analyzed. Analysis of variance was performed to determine differences in consensus intervals according to the use of data from the combined sample and selected samples.

Results: Median and mean platelet counts from the Chengdu center were significantly lower than those from other centers. Red blood cell count (RBC), hemoglobin (HGB), and hematocrit (HCT) values were higher in males than in females at all ages. Other CBC parameters showed no significant instrument-, region-, age-, or sex-dependent difference. Thalassemia carriers were found to affect the lower or upper limit of different RBC profiles.

Conclusion: We were able to establish consensus intervals for CBC parameters in healthy Han Chinese adults. RBC, HGB, and HCT intervals were established for each sex. The reference interval for platelets for the Chengdu center should be established independently.

Show MeSH
Related in: MedlinePlus