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Complete blood count reference intervals for healthy Han Chinese adults.

Wu X, Zhao M, Pan B, Zhang J, Peng M, Wang L, Hao X, Huang X, Mu R, Guo W, Qiao R, Chen W, Jiang H, Ma Y, Shang H - PLoS ONE (2015)

Bottom Line: Median and mean platelet counts from the Chengdu center were significantly lower than those from other centers.Other CBC parameters showed no significant instrument-, region-, age-, or sex-dependent difference.The reference interval for platelets for the Chengdu center should be established independently.

View Article: PubMed Central - PubMed

Affiliation: Department of Laboratory Science, the Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangdong, China.

ABSTRACT

Background: Complete blood count (CBC) reference intervals are important to diagnose diseases, screen blood donors, and assess overall health. However, current reference intervals established by older instruments and technologies and those from American and European populations are not suitable for Chinese samples due to ethnic, dietary, and lifestyle differences. The aim of this multicenter collaborative study was to establish CBC reference intervals for healthy Han Chinese adults.

Methods: A total of 4,642 healthy individuals (2,136 males and 2,506 females) were recruited from six clinical centers in China (Shenyang, Beijing, Shanghai, Guangzhou, Chengdu, and Xi'an). Blood samples collected in K2EDTA anticoagulant tubes were analyzed. Analysis of variance was performed to determine differences in consensus intervals according to the use of data from the combined sample and selected samples.

Results: Median and mean platelet counts from the Chengdu center were significantly lower than those from other centers. Red blood cell count (RBC), hemoglobin (HGB), and hematocrit (HCT) values were higher in males than in females at all ages. Other CBC parameters showed no significant instrument-, region-, age-, or sex-dependent difference. Thalassemia carriers were found to affect the lower or upper limit of different RBC profiles.

Conclusion: We were able to establish consensus intervals for CBC parameters in healthy Han Chinese adults. RBC, HGB, and HCT intervals were established for each sex. The reference interval for platelets for the Chengdu center should be established independently.

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Related in: MedlinePlus

Mean platelet count (PLT, A), red blood cell count (RBC, B), mean corpuscular volume (MCV, C), and mean corpuscular hemoglobin (MCH, D) value according to the use of different instruments.
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pone.0119669.g002: Mean platelet count (PLT, A), red blood cell count (RBC, B), mean corpuscular volume (MCV, C), and mean corpuscular hemoglobin (MCH, D) value according to the use of different instruments.

Mentions: No statistically significant differences in the RBC, MCV, MCH, and PLT parameters were observed between the Mindray BC-5800 and SYSMEX XE-5000 analyzers (Fig. 2A-2D; P > 0.05). Similar results were obtained for HGB, HCT, MCHC, WBC, and WBC differentials between the two instruments (data not shown; P > 0.05). Thus, the data obtained for each parameter from each instrument could be pooled to determine the consensus intervals.


Complete blood count reference intervals for healthy Han Chinese adults.

Wu X, Zhao M, Pan B, Zhang J, Peng M, Wang L, Hao X, Huang X, Mu R, Guo W, Qiao R, Chen W, Jiang H, Ma Y, Shang H - PLoS ONE (2015)

Mean platelet count (PLT, A), red blood cell count (RBC, B), mean corpuscular volume (MCV, C), and mean corpuscular hemoglobin (MCH, D) value according to the use of different instruments.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4358890&req=5

pone.0119669.g002: Mean platelet count (PLT, A), red blood cell count (RBC, B), mean corpuscular volume (MCV, C), and mean corpuscular hemoglobin (MCH, D) value according to the use of different instruments.
Mentions: No statistically significant differences in the RBC, MCV, MCH, and PLT parameters were observed between the Mindray BC-5800 and SYSMEX XE-5000 analyzers (Fig. 2A-2D; P > 0.05). Similar results were obtained for HGB, HCT, MCHC, WBC, and WBC differentials between the two instruments (data not shown; P > 0.05). Thus, the data obtained for each parameter from each instrument could be pooled to determine the consensus intervals.

Bottom Line: Median and mean platelet counts from the Chengdu center were significantly lower than those from other centers.Other CBC parameters showed no significant instrument-, region-, age-, or sex-dependent difference.The reference interval for platelets for the Chengdu center should be established independently.

View Article: PubMed Central - PubMed

Affiliation: Department of Laboratory Science, the Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangdong, China.

ABSTRACT

Background: Complete blood count (CBC) reference intervals are important to diagnose diseases, screen blood donors, and assess overall health. However, current reference intervals established by older instruments and technologies and those from American and European populations are not suitable for Chinese samples due to ethnic, dietary, and lifestyle differences. The aim of this multicenter collaborative study was to establish CBC reference intervals for healthy Han Chinese adults.

Methods: A total of 4,642 healthy individuals (2,136 males and 2,506 females) were recruited from six clinical centers in China (Shenyang, Beijing, Shanghai, Guangzhou, Chengdu, and Xi'an). Blood samples collected in K2EDTA anticoagulant tubes were analyzed. Analysis of variance was performed to determine differences in consensus intervals according to the use of data from the combined sample and selected samples.

Results: Median and mean platelet counts from the Chengdu center were significantly lower than those from other centers. Red blood cell count (RBC), hemoglobin (HGB), and hematocrit (HCT) values were higher in males than in females at all ages. Other CBC parameters showed no significant instrument-, region-, age-, or sex-dependent difference. Thalassemia carriers were found to affect the lower or upper limit of different RBC profiles.

Conclusion: We were able to establish consensus intervals for CBC parameters in healthy Han Chinese adults. RBC, HGB, and HCT intervals were established for each sex. The reference interval for platelets for the Chengdu center should be established independently.

Show MeSH
Related in: MedlinePlus