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Complete blood count reference intervals for healthy Han Chinese adults.

Wu X, Zhao M, Pan B, Zhang J, Peng M, Wang L, Hao X, Huang X, Mu R, Guo W, Qiao R, Chen W, Jiang H, Ma Y, Shang H - PLoS ONE (2015)

Bottom Line: Median and mean platelet counts from the Chengdu center were significantly lower than those from other centers.Other CBC parameters showed no significant instrument-, region-, age-, or sex-dependent difference.The reference interval for platelets for the Chengdu center should be established independently.

View Article: PubMed Central - PubMed

Affiliation: Department of Laboratory Science, the Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangdong, China.

ABSTRACT

Background: Complete blood count (CBC) reference intervals are important to diagnose diseases, screen blood donors, and assess overall health. However, current reference intervals established by older instruments and technologies and those from American and European populations are not suitable for Chinese samples due to ethnic, dietary, and lifestyle differences. The aim of this multicenter collaborative study was to establish CBC reference intervals for healthy Han Chinese adults.

Methods: A total of 4,642 healthy individuals (2,136 males and 2,506 females) were recruited from six clinical centers in China (Shenyang, Beijing, Shanghai, Guangzhou, Chengdu, and Xi'an). Blood samples collected in K2EDTA anticoagulant tubes were analyzed. Analysis of variance was performed to determine differences in consensus intervals according to the use of data from the combined sample and selected samples.

Results: Median and mean platelet counts from the Chengdu center were significantly lower than those from other centers. Red blood cell count (RBC), hemoglobin (HGB), and hematocrit (HCT) values were higher in males than in females at all ages. Other CBC parameters showed no significant instrument-, region-, age-, or sex-dependent difference. Thalassemia carriers were found to affect the lower or upper limit of different RBC profiles.

Conclusion: We were able to establish consensus intervals for CBC parameters in healthy Han Chinese adults. RBC, HGB, and HCT intervals were established for each sex. The reference interval for platelets for the Chengdu center should be established independently.

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Related in: MedlinePlus

Median and mean platelet counts (PLT, A) and eosinophil (EO, B) values for different regions and sexes.
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pone.0119669.g001: Median and mean platelet counts (PLT, A) and eosinophil (EO, B) values for different regions and sexes.

Mentions: Median and mean values of the PLT parameter in samples from the Chengdu center were significantly lower than values from other centers (Fig. 1A; P < 0.05). The difference between means was greater than 25% of the width of the 95% reference interval estimated from the combined sample data; therefore, data from the Chengdu center were excluded from the consensus interval for PLT. Median and mean EO values were significantly greater in samples from the Guangzhou center than in those from other centers (Fig. 1B; P < 0.05). However, the difference between means was minor, and EO data from all centers could be combined to calculate the consensus interval.


Complete blood count reference intervals for healthy Han Chinese adults.

Wu X, Zhao M, Pan B, Zhang J, Peng M, Wang L, Hao X, Huang X, Mu R, Guo W, Qiao R, Chen W, Jiang H, Ma Y, Shang H - PLoS ONE (2015)

Median and mean platelet counts (PLT, A) and eosinophil (EO, B) values for different regions and sexes.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4358890&req=5

pone.0119669.g001: Median and mean platelet counts (PLT, A) and eosinophil (EO, B) values for different regions and sexes.
Mentions: Median and mean values of the PLT parameter in samples from the Chengdu center were significantly lower than values from other centers (Fig. 1A; P < 0.05). The difference between means was greater than 25% of the width of the 95% reference interval estimated from the combined sample data; therefore, data from the Chengdu center were excluded from the consensus interval for PLT. Median and mean EO values were significantly greater in samples from the Guangzhou center than in those from other centers (Fig. 1B; P < 0.05). However, the difference between means was minor, and EO data from all centers could be combined to calculate the consensus interval.

Bottom Line: Median and mean platelet counts from the Chengdu center were significantly lower than those from other centers.Other CBC parameters showed no significant instrument-, region-, age-, or sex-dependent difference.The reference interval for platelets for the Chengdu center should be established independently.

View Article: PubMed Central - PubMed

Affiliation: Department of Laboratory Science, the Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangdong, China.

ABSTRACT

Background: Complete blood count (CBC) reference intervals are important to diagnose diseases, screen blood donors, and assess overall health. However, current reference intervals established by older instruments and technologies and those from American and European populations are not suitable for Chinese samples due to ethnic, dietary, and lifestyle differences. The aim of this multicenter collaborative study was to establish CBC reference intervals for healthy Han Chinese adults.

Methods: A total of 4,642 healthy individuals (2,136 males and 2,506 females) were recruited from six clinical centers in China (Shenyang, Beijing, Shanghai, Guangzhou, Chengdu, and Xi'an). Blood samples collected in K2EDTA anticoagulant tubes were analyzed. Analysis of variance was performed to determine differences in consensus intervals according to the use of data from the combined sample and selected samples.

Results: Median and mean platelet counts from the Chengdu center were significantly lower than those from other centers. Red blood cell count (RBC), hemoglobin (HGB), and hematocrit (HCT) values were higher in males than in females at all ages. Other CBC parameters showed no significant instrument-, region-, age-, or sex-dependent difference. Thalassemia carriers were found to affect the lower or upper limit of different RBC profiles.

Conclusion: We were able to establish consensus intervals for CBC parameters in healthy Han Chinese adults. RBC, HGB, and HCT intervals were established for each sex. The reference interval for platelets for the Chengdu center should be established independently.

Show MeSH
Related in: MedlinePlus