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Rosa damascena oil improves SSRI-induced sexual dysfunction in male patients suffering from major depressive disorders: results from a double-blind, randomized, and placebo-controlled clinical trial.

Farnia V, Shirzadifar M, Shakeri J, Rezaei M, Bajoghli H, Holsboer-Trachsler E, Brand S - Neuropsychiatr Dis Treat (2015)

Bottom Line: A substantial disadvantage of psychopharmacological treatment of major depressive disorder (MDD) with selective serotonin-reuptake inhibitors (SSRIs) is the impact on sexual dysfunction.Improvements were observed in the verum group from week 4 to week 8.Self-rated symptoms of depression reduced over time in both groups, but did so more so in the verum group than in the control group.

View Article: PubMed Central - PubMed

Affiliation: Substance Abuse Prevention Research Center, Psychiatry Department, Kermanshah University of Medical Sciences, Kermanshah, Iran.

ABSTRACT

Background: A substantial disadvantage of psychopharmacological treatment of major depressive disorder (MDD) with selective serotonin-reuptake inhibitors (SSRIs) is the impact on sexual dysfunction. The aim of the present study was to investigate whether the oil of Rosa damascena can have a positive influence on SSRI-induced sexual dysfunction (SSRI-I SD) of male patients who are suffering from MDD and are being treated with SSRIs.

Method: In a double-blind, randomized, and placebo-controlled clinical trial, a total of 60 male patients treated with an SSRI and suffering from MDD (mean age =32 years) and SSRI-I SD were randomly assigned to take either verum (R. damascena oil) or a placebo. Patients completed self-ratings of depression and sexual function at baseline, at 4 weeks later, and at the end of the study, 8 weeks after it started.

Results: Over time, sexual dysfunction improved more in the verum group than in the control group. Improvements were observed in the verum group from week 4 to week 8. Self-rated symptoms of depression reduced over time in both groups, but did so more so in the verum group than in the control group.

Conclusion: This double-blind, randomized, and placebo-controlled clinical trial showed that the administration of R. damascena oil ameliorates sexual dysfunction in male patients suffering from both MDD and SSRI-I SD. Further, the symptoms of depression reduced as sexual dysfunction improved.

No MeSH data available.


Related in: MedlinePlus

Comparison of BDI scores between verum and placebo groups.Notes: Over time, symptoms of depression (BDI scores) decreased significantly more in the verum (Rosa damascena extract) group than in the placebo group. Points are means, and bars are standard deviations.Abbreviation: BDI, Beck Depression Inventory.
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f3-ndt-11-625: Comparison of BDI scores between verum and placebo groups.Notes: Over time, symptoms of depression (BDI scores) decreased significantly more in the verum (Rosa damascena extract) group than in the placebo group. Points are means, and bars are standard deviations.Abbreviation: BDI, Beck Depression Inventory.

Mentions: Patients rated their depressive symptoms via the BDI at baseline and at the end of the study (Tables 1 and 2 and Figure 3). Depressive symptoms declined over time; the significant time × group interaction showed that depressive symptoms declined more in the verum group than in the placebo group.


Rosa damascena oil improves SSRI-induced sexual dysfunction in male patients suffering from major depressive disorders: results from a double-blind, randomized, and placebo-controlled clinical trial.

Farnia V, Shirzadifar M, Shakeri J, Rezaei M, Bajoghli H, Holsboer-Trachsler E, Brand S - Neuropsychiatr Dis Treat (2015)

Comparison of BDI scores between verum and placebo groups.Notes: Over time, symptoms of depression (BDI scores) decreased significantly more in the verum (Rosa damascena extract) group than in the placebo group. Points are means, and bars are standard deviations.Abbreviation: BDI, Beck Depression Inventory.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4358691&req=5

f3-ndt-11-625: Comparison of BDI scores between verum and placebo groups.Notes: Over time, symptoms of depression (BDI scores) decreased significantly more in the verum (Rosa damascena extract) group than in the placebo group. Points are means, and bars are standard deviations.Abbreviation: BDI, Beck Depression Inventory.
Mentions: Patients rated their depressive symptoms via the BDI at baseline and at the end of the study (Tables 1 and 2 and Figure 3). Depressive symptoms declined over time; the significant time × group interaction showed that depressive symptoms declined more in the verum group than in the placebo group.

Bottom Line: A substantial disadvantage of psychopharmacological treatment of major depressive disorder (MDD) with selective serotonin-reuptake inhibitors (SSRIs) is the impact on sexual dysfunction.Improvements were observed in the verum group from week 4 to week 8.Self-rated symptoms of depression reduced over time in both groups, but did so more so in the verum group than in the control group.

View Article: PubMed Central - PubMed

Affiliation: Substance Abuse Prevention Research Center, Psychiatry Department, Kermanshah University of Medical Sciences, Kermanshah, Iran.

ABSTRACT

Background: A substantial disadvantage of psychopharmacological treatment of major depressive disorder (MDD) with selective serotonin-reuptake inhibitors (SSRIs) is the impact on sexual dysfunction. The aim of the present study was to investigate whether the oil of Rosa damascena can have a positive influence on SSRI-induced sexual dysfunction (SSRI-I SD) of male patients who are suffering from MDD and are being treated with SSRIs.

Method: In a double-blind, randomized, and placebo-controlled clinical trial, a total of 60 male patients treated with an SSRI and suffering from MDD (mean age =32 years) and SSRI-I SD were randomly assigned to take either verum (R. damascena oil) or a placebo. Patients completed self-ratings of depression and sexual function at baseline, at 4 weeks later, and at the end of the study, 8 weeks after it started.

Results: Over time, sexual dysfunction improved more in the verum group than in the control group. Improvements were observed in the verum group from week 4 to week 8. Self-rated symptoms of depression reduced over time in both groups, but did so more so in the verum group than in the control group.

Conclusion: This double-blind, randomized, and placebo-controlled clinical trial showed that the administration of R. damascena oil ameliorates sexual dysfunction in male patients suffering from both MDD and SSRI-I SD. Further, the symptoms of depression reduced as sexual dysfunction improved.

No MeSH data available.


Related in: MedlinePlus