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Statin myalgia is not associated with reduced muscle strength, mass or protein turnover in older male volunteers, but is allied with a slowing of time to peak power output, insulin resistance and differential muscle mRNA expression.

Mallinson JE, Marimuthu K, Murton A, Selby A, Smith K, Constantin-Teodosiu D, Rennie MJ, Greenhaff PL - J. Physiol. (Lond.) (2015)

Bottom Line: Statins are associated with muscle myalgia and myopathy, which probably reduce habitual physical activity.Statin myalgic subjects had reduced whole body (P = 0.05) and leg (P < 0.01) glucose disposal, greater abdominal adiposity (P < 0.05) and differential expression of 33 muscle mRNAs (5% false discovery rate (FDR)), six of which, linked to mitochondrial dysfunction and apoptosis, increased at 1% FDR.Statin myalgia was associated with impaired muscle function, increased abdominal adiposity, whole body and leg insulin resistance, and evidence of mitochondrial dysfunction and apoptosis.

View Article: PubMed Central - PubMed

Affiliation: MRC/Arthritis Research UK Centre for Musculoskeletal Ageing Research, University of Nottingham, Nottingham, NG7 2UH, UK.

No MeSH data available.


Related in: MedlinePlus

Expression levels of proteins involved in translation initiation of muscle protein synthesis in skeletal muscle in control and statin user groupsA, ratio of muscle phosphorylated to total p70S6k protein expression; and B, ratio of muscle phosphorylated to total 4EBP1 protein expression. *P < 0.05 compared to control within the fed state clamp. Values are expressed as mean intensity (normalised to β-actin) ± SEM.
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fig06: Expression levels of proteins involved in translation initiation of muscle protein synthesis in skeletal muscle in control and statin user groupsA, ratio of muscle phosphorylated to total p70S6k protein expression; and B, ratio of muscle phosphorylated to total 4EBP1 protein expression. *P < 0.05 compared to control within the fed state clamp. Values are expressed as mean intensity (normalised to β-actin) ± SEM.

Mentions: There was no change in the ratio of muscle phosphorylated to total p70S6k protein expression from basal during the fasted state insulin clamp when comparing control and statin myalgic subjects. The fed state clamp tended to increase p70S6k protein phosphorylation in statin myalgic subjects above control (P = 0.08, Fig. 6A). Similarly, there was no change from basal in the ratio of phosphorylated to total 4EBP1 protein expression during the fasted state insulin clamp in both experimental groups. However, 4EBP1 phosphorylation was significantly greater in the statin myalgic subjects at the end of the fed state clamp relative to the control group (P < 0.05, Fig. 6B). The greater phosphorylation status of p70S6k and 4EBP1 at the end of the fed state clamp in the statin myalgic subjects relative to control probably reflects the trend for steady-state serum insulin concentration to be greater in the statin group (Fig. 4A).


Statin myalgia is not associated with reduced muscle strength, mass or protein turnover in older male volunteers, but is allied with a slowing of time to peak power output, insulin resistance and differential muscle mRNA expression.

Mallinson JE, Marimuthu K, Murton A, Selby A, Smith K, Constantin-Teodosiu D, Rennie MJ, Greenhaff PL - J. Physiol. (Lond.) (2015)

Expression levels of proteins involved in translation initiation of muscle protein synthesis in skeletal muscle in control and statin user groupsA, ratio of muscle phosphorylated to total p70S6k protein expression; and B, ratio of muscle phosphorylated to total 4EBP1 protein expression. *P < 0.05 compared to control within the fed state clamp. Values are expressed as mean intensity (normalised to β-actin) ± SEM.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4358682&req=5

fig06: Expression levels of proteins involved in translation initiation of muscle protein synthesis in skeletal muscle in control and statin user groupsA, ratio of muscle phosphorylated to total p70S6k protein expression; and B, ratio of muscle phosphorylated to total 4EBP1 protein expression. *P < 0.05 compared to control within the fed state clamp. Values are expressed as mean intensity (normalised to β-actin) ± SEM.
Mentions: There was no change in the ratio of muscle phosphorylated to total p70S6k protein expression from basal during the fasted state insulin clamp when comparing control and statin myalgic subjects. The fed state clamp tended to increase p70S6k protein phosphorylation in statin myalgic subjects above control (P = 0.08, Fig. 6A). Similarly, there was no change from basal in the ratio of phosphorylated to total 4EBP1 protein expression during the fasted state insulin clamp in both experimental groups. However, 4EBP1 phosphorylation was significantly greater in the statin myalgic subjects at the end of the fed state clamp relative to the control group (P < 0.05, Fig. 6B). The greater phosphorylation status of p70S6k and 4EBP1 at the end of the fed state clamp in the statin myalgic subjects relative to control probably reflects the trend for steady-state serum insulin concentration to be greater in the statin group (Fig. 4A).

Bottom Line: Statins are associated with muscle myalgia and myopathy, which probably reduce habitual physical activity.Statin myalgic subjects had reduced whole body (P = 0.05) and leg (P < 0.01) glucose disposal, greater abdominal adiposity (P < 0.05) and differential expression of 33 muscle mRNAs (5% false discovery rate (FDR)), six of which, linked to mitochondrial dysfunction and apoptosis, increased at 1% FDR.Statin myalgia was associated with impaired muscle function, increased abdominal adiposity, whole body and leg insulin resistance, and evidence of mitochondrial dysfunction and apoptosis.

View Article: PubMed Central - PubMed

Affiliation: MRC/Arthritis Research UK Centre for Musculoskeletal Ageing Research, University of Nottingham, Nottingham, NG7 2UH, UK.

No MeSH data available.


Related in: MedlinePlus