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Statin myalgia is not associated with reduced muscle strength, mass or protein turnover in older male volunteers, but is allied with a slowing of time to peak power output, insulin resistance and differential muscle mRNA expression.

Mallinson JE, Marimuthu K, Murton A, Selby A, Smith K, Constantin-Teodosiu D, Rennie MJ, Greenhaff PL - J. Physiol. (Lond.) (2015)

Bottom Line: Statins are associated with muscle myalgia and myopathy, which probably reduce habitual physical activity.Statin myalgic subjects had reduced whole body (P = 0.05) and leg (P < 0.01) glucose disposal, greater abdominal adiposity (P < 0.05) and differential expression of 33 muscle mRNAs (5% false discovery rate (FDR)), six of which, linked to mitochondrial dysfunction and apoptosis, increased at 1% FDR.Statin myalgia was associated with impaired muscle function, increased abdominal adiposity, whole body and leg insulin resistance, and evidence of mitochondrial dysfunction and apoptosis.

View Article: PubMed Central - PubMed

Affiliation: MRC/Arthritis Research UK Centre for Musculoskeletal Ageing Research, University of Nottingham, Nottingham, NG7 2UH, UK.

No MeSH data available.


Related in: MedlinePlus

Muscle protein synthesis and leg protein breakdown in control and statin user groupsA, rate of muscle protein synthesis (fractional synthetic rate, FSR) during a 2 h fasted state insulin clamp (0.6 mU m−2 min−1 insulin) and a 2 h fed state insulin clamp (40 mU m−2 min−1 insulin and 10 g h−1 mixed AAs); B, rate of leg protein breakdown during a 2 h fasted state and a 2 h fed state insulin clamp. Values are expressed as mean ± SEM. ***P < 0.001 when fasted vs. fed clamp.
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fig05: Muscle protein synthesis and leg protein breakdown in control and statin user groupsA, rate of muscle protein synthesis (fractional synthetic rate, FSR) during a 2 h fasted state insulin clamp (0.6 mU m−2 min−1 insulin) and a 2 h fed state insulin clamp (40 mU m−2 min−1 insulin and 10 g h−1 mixed AAs); B, rate of leg protein breakdown during a 2 h fasted state and a 2 h fed state insulin clamp. Values are expressed as mean ± SEM. ***P < 0.001 when fasted vs. fed clamp.

Mentions: The rate of MPS was similar between control and statin myalgic subjects during the fasting insulin clamp (Fig. 5A). As expected, the fed state clamp nearly doubled MPS (P < 0.001 for both groups), but the magnitude of the increase was not different between groups (Fig. 5A). LPB was not different between the control and statin myalgic subjects during the fasting insulin clamp (Fig. 5B). Furthermore, no statistical difference was seen when comparing treatment groups during the fed state insulin clamp, although the average reduction in LPB by insulin was greater in the statin myalgic subjects (Fig. 5B), probably reflecting the trend for steady-state serum insulin concentration to be greater in this group (Fig. 4A).


Statin myalgia is not associated with reduced muscle strength, mass or protein turnover in older male volunteers, but is allied with a slowing of time to peak power output, insulin resistance and differential muscle mRNA expression.

Mallinson JE, Marimuthu K, Murton A, Selby A, Smith K, Constantin-Teodosiu D, Rennie MJ, Greenhaff PL - J. Physiol. (Lond.) (2015)

Muscle protein synthesis and leg protein breakdown in control and statin user groupsA, rate of muscle protein synthesis (fractional synthetic rate, FSR) during a 2 h fasted state insulin clamp (0.6 mU m−2 min−1 insulin) and a 2 h fed state insulin clamp (40 mU m−2 min−1 insulin and 10 g h−1 mixed AAs); B, rate of leg protein breakdown during a 2 h fasted state and a 2 h fed state insulin clamp. Values are expressed as mean ± SEM. ***P < 0.001 when fasted vs. fed clamp.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4358682&req=5

fig05: Muscle protein synthesis and leg protein breakdown in control and statin user groupsA, rate of muscle protein synthesis (fractional synthetic rate, FSR) during a 2 h fasted state insulin clamp (0.6 mU m−2 min−1 insulin) and a 2 h fed state insulin clamp (40 mU m−2 min−1 insulin and 10 g h−1 mixed AAs); B, rate of leg protein breakdown during a 2 h fasted state and a 2 h fed state insulin clamp. Values are expressed as mean ± SEM. ***P < 0.001 when fasted vs. fed clamp.
Mentions: The rate of MPS was similar between control and statin myalgic subjects during the fasting insulin clamp (Fig. 5A). As expected, the fed state clamp nearly doubled MPS (P < 0.001 for both groups), but the magnitude of the increase was not different between groups (Fig. 5A). LPB was not different between the control and statin myalgic subjects during the fasting insulin clamp (Fig. 5B). Furthermore, no statistical difference was seen when comparing treatment groups during the fed state insulin clamp, although the average reduction in LPB by insulin was greater in the statin myalgic subjects (Fig. 5B), probably reflecting the trend for steady-state serum insulin concentration to be greater in this group (Fig. 4A).

Bottom Line: Statins are associated with muscle myalgia and myopathy, which probably reduce habitual physical activity.Statin myalgic subjects had reduced whole body (P = 0.05) and leg (P < 0.01) glucose disposal, greater abdominal adiposity (P < 0.05) and differential expression of 33 muscle mRNAs (5% false discovery rate (FDR)), six of which, linked to mitochondrial dysfunction and apoptosis, increased at 1% FDR.Statin myalgia was associated with impaired muscle function, increased abdominal adiposity, whole body and leg insulin resistance, and evidence of mitochondrial dysfunction and apoptosis.

View Article: PubMed Central - PubMed

Affiliation: MRC/Arthritis Research UK Centre for Musculoskeletal Ageing Research, University of Nottingham, Nottingham, NG7 2UH, UK.

No MeSH data available.


Related in: MedlinePlus