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Statin myalgia is not associated with reduced muscle strength, mass or protein turnover in older male volunteers, but is allied with a slowing of time to peak power output, insulin resistance and differential muscle mRNA expression.

Mallinson JE, Marimuthu K, Murton A, Selby A, Smith K, Constantin-Teodosiu D, Rennie MJ, Greenhaff PL - J. Physiol. (Lond.) (2015)

Bottom Line: Statins are associated with muscle myalgia and myopathy, which probably reduce habitual physical activity.Statin myalgic subjects had reduced whole body (P = 0.05) and leg (P < 0.01) glucose disposal, greater abdominal adiposity (P < 0.05) and differential expression of 33 muscle mRNAs (5% false discovery rate (FDR)), six of which, linked to mitochondrial dysfunction and apoptosis, increased at 1% FDR.Statin myalgia was associated with impaired muscle function, increased abdominal adiposity, whole body and leg insulin resistance, and evidence of mitochondrial dysfunction and apoptosis.

View Article: PubMed Central - PubMed

Affiliation: MRC/Arthritis Research UK Centre for Musculoskeletal Ageing Research, University of Nottingham, Nottingham, NG7 2UH, UK.

No MeSH data available.


Related in: MedlinePlus

Muscle functional measurements in control and statin user groupsA, isometric strength (kg kg leg lean mass−1); B, peak power output (W kg leg lean mass−1); C, peak isokinetic work per contraction (Nm) during 30 maximal isokinetic contractions. Values are expressed as mean ± SEM. *P < 0.05 compared to control.
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fig03: Muscle functional measurements in control and statin user groupsA, isometric strength (kg kg leg lean mass−1); B, peak power output (W kg leg lean mass−1); C, peak isokinetic work per contraction (Nm) during 30 maximal isokinetic contractions. Values are expressed as mean ± SEM. *P < 0.05 compared to control.

Mentions: Isometric strength of the knee extensors was not different between control and statin myalgic subjects (Fig. 3A). Similarly, peak power output during 30 maximal knee extensor contractions was not different between groups (Fig. 3B). However, whilst the control group achieved peak power at the third contraction, the statin user group achieved peak power output at the twelfth contraction, producing significantly less work output per contraction at the onset of exercise (Fig. 3C, P < 0.05).


Statin myalgia is not associated with reduced muscle strength, mass or protein turnover in older male volunteers, but is allied with a slowing of time to peak power output, insulin resistance and differential muscle mRNA expression.

Mallinson JE, Marimuthu K, Murton A, Selby A, Smith K, Constantin-Teodosiu D, Rennie MJ, Greenhaff PL - J. Physiol. (Lond.) (2015)

Muscle functional measurements in control and statin user groupsA, isometric strength (kg kg leg lean mass−1); B, peak power output (W kg leg lean mass−1); C, peak isokinetic work per contraction (Nm) during 30 maximal isokinetic contractions. Values are expressed as mean ± SEM. *P < 0.05 compared to control.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4358682&req=5

fig03: Muscle functional measurements in control and statin user groupsA, isometric strength (kg kg leg lean mass−1); B, peak power output (W kg leg lean mass−1); C, peak isokinetic work per contraction (Nm) during 30 maximal isokinetic contractions. Values are expressed as mean ± SEM. *P < 0.05 compared to control.
Mentions: Isometric strength of the knee extensors was not different between control and statin myalgic subjects (Fig. 3A). Similarly, peak power output during 30 maximal knee extensor contractions was not different between groups (Fig. 3B). However, whilst the control group achieved peak power at the third contraction, the statin user group achieved peak power output at the twelfth contraction, producing significantly less work output per contraction at the onset of exercise (Fig. 3C, P < 0.05).

Bottom Line: Statins are associated with muscle myalgia and myopathy, which probably reduce habitual physical activity.Statin myalgic subjects had reduced whole body (P = 0.05) and leg (P < 0.01) glucose disposal, greater abdominal adiposity (P < 0.05) and differential expression of 33 muscle mRNAs (5% false discovery rate (FDR)), six of which, linked to mitochondrial dysfunction and apoptosis, increased at 1% FDR.Statin myalgia was associated with impaired muscle function, increased abdominal adiposity, whole body and leg insulin resistance, and evidence of mitochondrial dysfunction and apoptosis.

View Article: PubMed Central - PubMed

Affiliation: MRC/Arthritis Research UK Centre for Musculoskeletal Ageing Research, University of Nottingham, Nottingham, NG7 2UH, UK.

No MeSH data available.


Related in: MedlinePlus