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Long-term outcomes of intravitreal injection of bevacizumab for choroidal neovascularization associated with choroidal osteoma.

Yoshikawa T, Takahashi K - Clin Ophthalmol (2015)

Bottom Line: The mean central foveal thickness decreased from 407 μm to 251 μm.The mean tumor thickness decreased from 709 μm to 608 μm.Intravitreal injections of bevacizumab for subfoveal CNV associated with decalcified choroidal osteoma resulted in poor visual acuity.

View Article: PubMed Central - PubMed

Affiliation: Department of Ophthalmology, Kansai Medical University, Osaka, Japan.

ABSTRACT

Purpose: To describe the outcomes of intravitreal injections of bevacizumab for choroidal neovascularization (CNV) associated with choroidal osteoma.

Methods: Retrospective consecutive case series. Three eyes of three patients were studied. All patients were treated with intravitreal injections of bevacizumab for CNV associated with choroidal osteoma. Best-corrected visual acuity, central foveal thickness, tumor thickness on spectral domain optical coherence tomography, and subretinal pigmentation around the CNV were evaluated.

Results: The mean number of intravitreal injections of bevacizumab was 2.0 (range 1-3). The mean follow-up time was 56.0 months (range 25-99 months). The mean LogMAR visual acuity worsened from 0.1 to 0.6. LogMAR visual acuity loss of 0.7 or worse occurred in two of three eyes. CNV was located in the subfoveal area in two eyes, and CNV was located in the juxtafoveal area in one eye. The mean central foveal thickness decreased from 407 μm to 251 μm. The mean tumor thickness decreased from 709 μm to 608 μm. All eyes had subretinal pigmentation around the CNV.

Conclusion: Intravitreal injections of bevacizumab for subfoveal CNV associated with decalcified choroidal osteoma resulted in poor visual acuity.

No MeSH data available.


Related in: MedlinePlus

Photograph and spectral domain optical coherence tomography (SD-OCT) findings for case 2.Notes: (A) Thirty-one months after the first visit. A fundus photograph shows yellow–white lesions of approximately five disk diameters in size. There is no SD-OCT findings in the first visit of case 2. (B) Forty-three months after the first visit. SD-OCT shows subfoveal choroidal neovascularization with retinal edema and subretinal fluid. White arrow denotes longitudinal scans of the SD-OCT. (C) Forty-seven months after the first visit. Intravitreal injections of bevacizumab decreased the choroidal neovascularization and subretinal fluid. (D) Ninety-nine months after the first visit. Fundus photograph and SD-OCT show retinal pigment epithelium atrophy.
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f4-opth-9-429: Photograph and spectral domain optical coherence tomography (SD-OCT) findings for case 2.Notes: (A) Thirty-one months after the first visit. A fundus photograph shows yellow–white lesions of approximately five disk diameters in size. There is no SD-OCT findings in the first visit of case 2. (B) Forty-three months after the first visit. SD-OCT shows subfoveal choroidal neovascularization with retinal edema and subretinal fluid. White arrow denotes longitudinal scans of the SD-OCT. (C) Forty-seven months after the first visit. Intravitreal injections of bevacizumab decreased the choroidal neovascularization and subretinal fluid. (D) Ninety-nine months after the first visit. Fundus photograph and SD-OCT show retinal pigment epithelium atrophy.

Mentions: In case 2, fundus examination revealed yellow–white lesions of approximately five disk diameters in size with a strong deposition of subretinal pigmentation below the fovea. CNV was located in the subfoveal area. Although IVB decreased the exudation of CNV and retinal edema, the retinal layer was disrupted by the RPE atrophy (Figure 4).


Long-term outcomes of intravitreal injection of bevacizumab for choroidal neovascularization associated with choroidal osteoma.

Yoshikawa T, Takahashi K - Clin Ophthalmol (2015)

Photograph and spectral domain optical coherence tomography (SD-OCT) findings for case 2.Notes: (A) Thirty-one months after the first visit. A fundus photograph shows yellow–white lesions of approximately five disk diameters in size. There is no SD-OCT findings in the first visit of case 2. (B) Forty-three months after the first visit. SD-OCT shows subfoveal choroidal neovascularization with retinal edema and subretinal fluid. White arrow denotes longitudinal scans of the SD-OCT. (C) Forty-seven months after the first visit. Intravitreal injections of bevacizumab decreased the choroidal neovascularization and subretinal fluid. (D) Ninety-nine months after the first visit. Fundus photograph and SD-OCT show retinal pigment epithelium atrophy.
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Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4356687&req=5

f4-opth-9-429: Photograph and spectral domain optical coherence tomography (SD-OCT) findings for case 2.Notes: (A) Thirty-one months after the first visit. A fundus photograph shows yellow–white lesions of approximately five disk diameters in size. There is no SD-OCT findings in the first visit of case 2. (B) Forty-three months after the first visit. SD-OCT shows subfoveal choroidal neovascularization with retinal edema and subretinal fluid. White arrow denotes longitudinal scans of the SD-OCT. (C) Forty-seven months after the first visit. Intravitreal injections of bevacizumab decreased the choroidal neovascularization and subretinal fluid. (D) Ninety-nine months after the first visit. Fundus photograph and SD-OCT show retinal pigment epithelium atrophy.
Mentions: In case 2, fundus examination revealed yellow–white lesions of approximately five disk diameters in size with a strong deposition of subretinal pigmentation below the fovea. CNV was located in the subfoveal area. Although IVB decreased the exudation of CNV and retinal edema, the retinal layer was disrupted by the RPE atrophy (Figure 4).

Bottom Line: The mean central foveal thickness decreased from 407 μm to 251 μm.The mean tumor thickness decreased from 709 μm to 608 μm.Intravitreal injections of bevacizumab for subfoveal CNV associated with decalcified choroidal osteoma resulted in poor visual acuity.

View Article: PubMed Central - PubMed

Affiliation: Department of Ophthalmology, Kansai Medical University, Osaka, Japan.

ABSTRACT

Purpose: To describe the outcomes of intravitreal injections of bevacizumab for choroidal neovascularization (CNV) associated with choroidal osteoma.

Methods: Retrospective consecutive case series. Three eyes of three patients were studied. All patients were treated with intravitreal injections of bevacizumab for CNV associated with choroidal osteoma. Best-corrected visual acuity, central foveal thickness, tumor thickness on spectral domain optical coherence tomography, and subretinal pigmentation around the CNV were evaluated.

Results: The mean number of intravitreal injections of bevacizumab was 2.0 (range 1-3). The mean follow-up time was 56.0 months (range 25-99 months). The mean LogMAR visual acuity worsened from 0.1 to 0.6. LogMAR visual acuity loss of 0.7 or worse occurred in two of three eyes. CNV was located in the subfoveal area in two eyes, and CNV was located in the juxtafoveal area in one eye. The mean central foveal thickness decreased from 407 μm to 251 μm. The mean tumor thickness decreased from 709 μm to 608 μm. All eyes had subretinal pigmentation around the CNV.

Conclusion: Intravitreal injections of bevacizumab for subfoveal CNV associated with decalcified choroidal osteoma resulted in poor visual acuity.

No MeSH data available.


Related in: MedlinePlus