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Development of an oral push-pull osmotic pump of fenofibrate-loaded mesoporous silica nanoparticles.

Zhao Z, Wu C, Zhao Y, Hao Y, Liu Y, Zhao W - Int J Nanomedicine (2015)

Bottom Line: The in vitro dissolution studies indicated that the osmotic pump tablet combined with MSNs was able to deliver fenofibrate in an approximately zero-order manner in 24 hours.A pharmacokinetic study showed that, although the maximum plasma concentration of the osmotic pump was lower than that of the reference formulation, the relative bioavailability was increased, indicating that the osmotic pump was more efficient than the reference tablets.Therefore, using MSNs as a carrier for poorly water-soluble drugs is an effective method for preparing osmotic pump tablets.

View Article: PubMed Central - PubMed

Affiliation: Pharmacy School, Liaoning Medical University, Jinzhou, Liaoning Province, People's Republic of China.

ABSTRACT
In this study, mesoporous silica nanoparticles (MSNs) were used to prepare an oral push-pull osmotic pump. Fenofibrate, the selected model drug, was firstly loaded into the MSNs, followed by a suspending agent consisting of a drug layer of push-pull osmotic pump. Fenofibrate-loaded MSNs were characterized by scanning electron microscopy (SEM), transmission electron microscopy (TEM), nitrogen adsorption/desorption analysis, differential scanning calorimetry (DSC), powder X-ray diffractometry (PXRD) analysis, and Fourier-transform infrared (FT-IR) spectroscopy. Polyethylene oxide of molecular weight (MW) 100,000 and polyethylene oxide of MW 6,000,000 were selected as the suspending agent and the expanding agent, respectively. Cellulose acetate was used as the semipermeable membrane, along with polyethylene glycol 6,000 to increase the flexibility and control the membrane permeability. The in vitro dissolution studies indicated that the osmotic pump tablet combined with MSNs was able to deliver fenofibrate in an approximately zero-order manner in 24 hours. A pharmacokinetic study showed that, although the maximum plasma concentration of the osmotic pump was lower than that of the reference formulation, the relative bioavailability was increased, indicating that the osmotic pump was more efficient than the reference tablets. Therefore, using MSNs as a carrier for poorly water-soluble drugs is an effective method for preparing osmotic pump tablets.

No MeSH data available.


Cytotoxicity study of the MSNs in Caco-2 cells.Abbreviation: MSN, mesoporous silica nanoparticle.
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f10-ijn-10-1691: Cytotoxicity study of the MSNs in Caco-2 cells.Abbreviation: MSN, mesoporous silica nanoparticle.

Mentions: Figure 10 presented the cytotoxicity of different concentrations of MSNs on Caco-2 cells in 24 hours. As can be seen, cell viability was dependent on the concentration of MSNs. When the concentration increased, there was a slight decrease in cell viability, but the cell viability remained above 90%, which indicated that the MSNs exhibited no significant cytotoxicity on Caco-2 cells; at the concentration of 20–500 μg/mL, all the cells treated with MSNs could survive and maintain a normal growth rate. MSNs only produced a slight toxicity at higher concentration. Therefore, MSNs are biocompatible and can be an excellent vehicle for drug delivery, as concluded in many related studies.7,34,35


Development of an oral push-pull osmotic pump of fenofibrate-loaded mesoporous silica nanoparticles.

Zhao Z, Wu C, Zhao Y, Hao Y, Liu Y, Zhao W - Int J Nanomedicine (2015)

Cytotoxicity study of the MSNs in Caco-2 cells.Abbreviation: MSN, mesoporous silica nanoparticle.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4356664&req=5

f10-ijn-10-1691: Cytotoxicity study of the MSNs in Caco-2 cells.Abbreviation: MSN, mesoporous silica nanoparticle.
Mentions: Figure 10 presented the cytotoxicity of different concentrations of MSNs on Caco-2 cells in 24 hours. As can be seen, cell viability was dependent on the concentration of MSNs. When the concentration increased, there was a slight decrease in cell viability, but the cell viability remained above 90%, which indicated that the MSNs exhibited no significant cytotoxicity on Caco-2 cells; at the concentration of 20–500 μg/mL, all the cells treated with MSNs could survive and maintain a normal growth rate. MSNs only produced a slight toxicity at higher concentration. Therefore, MSNs are biocompatible and can be an excellent vehicle for drug delivery, as concluded in many related studies.7,34,35

Bottom Line: The in vitro dissolution studies indicated that the osmotic pump tablet combined with MSNs was able to deliver fenofibrate in an approximately zero-order manner in 24 hours.A pharmacokinetic study showed that, although the maximum plasma concentration of the osmotic pump was lower than that of the reference formulation, the relative bioavailability was increased, indicating that the osmotic pump was more efficient than the reference tablets.Therefore, using MSNs as a carrier for poorly water-soluble drugs is an effective method for preparing osmotic pump tablets.

View Article: PubMed Central - PubMed

Affiliation: Pharmacy School, Liaoning Medical University, Jinzhou, Liaoning Province, People's Republic of China.

ABSTRACT
In this study, mesoporous silica nanoparticles (MSNs) were used to prepare an oral push-pull osmotic pump. Fenofibrate, the selected model drug, was firstly loaded into the MSNs, followed by a suspending agent consisting of a drug layer of push-pull osmotic pump. Fenofibrate-loaded MSNs were characterized by scanning electron microscopy (SEM), transmission electron microscopy (TEM), nitrogen adsorption/desorption analysis, differential scanning calorimetry (DSC), powder X-ray diffractometry (PXRD) analysis, and Fourier-transform infrared (FT-IR) spectroscopy. Polyethylene oxide of molecular weight (MW) 100,000 and polyethylene oxide of MW 6,000,000 were selected as the suspending agent and the expanding agent, respectively. Cellulose acetate was used as the semipermeable membrane, along with polyethylene glycol 6,000 to increase the flexibility and control the membrane permeability. The in vitro dissolution studies indicated that the osmotic pump tablet combined with MSNs was able to deliver fenofibrate in an approximately zero-order manner in 24 hours. A pharmacokinetic study showed that, although the maximum plasma concentration of the osmotic pump was lower than that of the reference formulation, the relative bioavailability was increased, indicating that the osmotic pump was more efficient than the reference tablets. Therefore, using MSNs as a carrier for poorly water-soluble drugs is an effective method for preparing osmotic pump tablets.

No MeSH data available.