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Invasive cribriform carcinoma of the breast: A report of nine cases and a review of the literature.

Cong Y, Qiao G, Zou H, Lin J, Wang X, Li X, Li Y, Zhu S - Oncol Lett (2015)

Bottom Line: Four patients were treated with mastectomy and the others with breast-conserving surgery.Following surgery, three patients received adjuvant chemotherapy, radiotherapy and hormonal therapy, respectively.With a median follow-up time of 38 months (range, 4-70 months), one patient developed local recurrence following breast-conserving surgery; axillary lymph nodes and distant metastases were not observed.

View Article: PubMed Central - PubMed

Affiliation: Department of Breast Surgery, Yantai Yuhuangding Hospital Affiliated to the Medical College of Qingdao University, Yantai, Shandong 264400, P.R. China.

ABSTRACT

Nine cases of infiltrating cribriform carcinoma (ICC) of the breast are reported and the clinicopathological features, particularly the imaging findings, are analyzed in the present study. Sonograms revealed that all masses exhibited a hypoechoic internal echo texture (9/9) and that a number of masses presented with an irregular shape (8/9), obscure boundary (5/9), partially microlobulated (5/9) or well-circumscribed (4/9) margins, and an inhomogeneous echo (8/9). Mammographic imaging revealed increased radiological density masses (6/8), and sand-like calcification was not observed in all patients. In two patients, the tumors were mammographically occult. Magnetic resonance imaging performed on one patient revealed a slightly high signal intensity on fat-saturated T1- and T2-weighted images. Following contrast enhancement, a homogeneous early enhancement was revealed with a quick ascent and quick descent time-density curve. Immunohistochemistry revealed that all ICCs expressed estrogen receptor and progesterone receptor, but that none were positive for human epidermal growth factor receptor 2. The Ki-67 labeling index was 3.75% (range, 2-5%) in the tumor tissue. Four patients were treated with mastectomy and the others with breast-conserving surgery. Six clinically node-negative patients underwent sentinel lymph node biopsy; three then received axillary lymph node dissection. Following surgery, three patients received adjuvant chemotherapy, radiotherapy and hormonal therapy, respectively. With a median follow-up time of 38 months (range, 4-70 months), one patient developed local recurrence following breast-conserving surgery; axillary lymph nodes and distant metastases were not observed. This study confirms that this type of carcinoma has unique biological characteristics and a favorable prognosis, but that it remains possible to experience local recurrence.

No MeSH data available.


Related in: MedlinePlus

Case 4 from Table I. (A and B) Magnetic resonance imaging findings. The mass measuring 1.3×0.9 cm exhibited a slightly high signal intensity on fat-saturated T1- and T2-weighted images. Following contrast enhancement, (A) a homogeneous early enhancement was revealed with (B) a quick ascent and descent time-density curve. (C) Echography imaging revealed that the low echo mass range of 1.2×0.7 cm was less regular in morphology with a well-defined margin and uneven echo. Color Doppler flow imaging detected no blood flow signal in and around the mass. (D) Pathological results revealed invasive cribriform carcinoma of the breast (hematoxylin and eosin staining; magnification, ×100).
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f2-ol-09-04-1753: Case 4 from Table I. (A and B) Magnetic resonance imaging findings. The mass measuring 1.3×0.9 cm exhibited a slightly high signal intensity on fat-saturated T1- and T2-weighted images. Following contrast enhancement, (A) a homogeneous early enhancement was revealed with (B) a quick ascent and descent time-density curve. (C) Echography imaging revealed that the low echo mass range of 1.2×0.7 cm was less regular in morphology with a well-defined margin and uneven echo. Color Doppler flow imaging detected no blood flow signal in and around the mass. (D) Pathological results revealed invasive cribriform carcinoma of the breast (hematoxylin and eosin staining; magnification, ×100).

Mentions: Tumor marker detection revealed that the level of carcinoembryonic antigen in the blood serum was high in one patient (4.01 ng/ml; normal range, 0–3.4 ng/ml) and that the ferritin level was high in two patients (193.0 and 181.7 ng/ml; normal range, 13–150 ng/ml). Pre-operative sonographic findings were available for review for all patients. Sonograms revealed that all masses exhibited a hypoechoic internal echo texture (9/9) and that a number of masses presented with an irregular shape (8/9), obscure boundary (5/9), partially microlobulated (5/9) or well-circumscribed (4/9) margins, and an inhomogeneous echo (8/9). Color Doppler flow imaging revealed markedly increased flow signals in two patients and a resistance index of 0.77 in one patient. Pre-operative mammographic imaging was available for review for eight patients. The tumors in two patients were mammographically occult. The other six tumors that were visible exhibited increased radiological density masses, and sand-like calcification was not observed in all patients (Fig. 1). Magnetic resonance imaging performed in one patient revealed that the mass exhibited a slightly high signal intensity on fat-saturated T1- and T2-weighted images. Following contrast enhancement, a homogeneous early enhancement was revealed with a quick ascent and quick descent time-density curve (Fig. 2).


Invasive cribriform carcinoma of the breast: A report of nine cases and a review of the literature.

Cong Y, Qiao G, Zou H, Lin J, Wang X, Li X, Li Y, Zhu S - Oncol Lett (2015)

Case 4 from Table I. (A and B) Magnetic resonance imaging findings. The mass measuring 1.3×0.9 cm exhibited a slightly high signal intensity on fat-saturated T1- and T2-weighted images. Following contrast enhancement, (A) a homogeneous early enhancement was revealed with (B) a quick ascent and descent time-density curve. (C) Echography imaging revealed that the low echo mass range of 1.2×0.7 cm was less regular in morphology with a well-defined margin and uneven echo. Color Doppler flow imaging detected no blood flow signal in and around the mass. (D) Pathological results revealed invasive cribriform carcinoma of the breast (hematoxylin and eosin staining; magnification, ×100).
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4356388&req=5

f2-ol-09-04-1753: Case 4 from Table I. (A and B) Magnetic resonance imaging findings. The mass measuring 1.3×0.9 cm exhibited a slightly high signal intensity on fat-saturated T1- and T2-weighted images. Following contrast enhancement, (A) a homogeneous early enhancement was revealed with (B) a quick ascent and descent time-density curve. (C) Echography imaging revealed that the low echo mass range of 1.2×0.7 cm was less regular in morphology with a well-defined margin and uneven echo. Color Doppler flow imaging detected no blood flow signal in and around the mass. (D) Pathological results revealed invasive cribriform carcinoma of the breast (hematoxylin and eosin staining; magnification, ×100).
Mentions: Tumor marker detection revealed that the level of carcinoembryonic antigen in the blood serum was high in one patient (4.01 ng/ml; normal range, 0–3.4 ng/ml) and that the ferritin level was high in two patients (193.0 and 181.7 ng/ml; normal range, 13–150 ng/ml). Pre-operative sonographic findings were available for review for all patients. Sonograms revealed that all masses exhibited a hypoechoic internal echo texture (9/9) and that a number of masses presented with an irregular shape (8/9), obscure boundary (5/9), partially microlobulated (5/9) or well-circumscribed (4/9) margins, and an inhomogeneous echo (8/9). Color Doppler flow imaging revealed markedly increased flow signals in two patients and a resistance index of 0.77 in one patient. Pre-operative mammographic imaging was available for review for eight patients. The tumors in two patients were mammographically occult. The other six tumors that were visible exhibited increased radiological density masses, and sand-like calcification was not observed in all patients (Fig. 1). Magnetic resonance imaging performed in one patient revealed that the mass exhibited a slightly high signal intensity on fat-saturated T1- and T2-weighted images. Following contrast enhancement, a homogeneous early enhancement was revealed with a quick ascent and quick descent time-density curve (Fig. 2).

Bottom Line: Four patients were treated with mastectomy and the others with breast-conserving surgery.Following surgery, three patients received adjuvant chemotherapy, radiotherapy and hormonal therapy, respectively.With a median follow-up time of 38 months (range, 4-70 months), one patient developed local recurrence following breast-conserving surgery; axillary lymph nodes and distant metastases were not observed.

View Article: PubMed Central - PubMed

Affiliation: Department of Breast Surgery, Yantai Yuhuangding Hospital Affiliated to the Medical College of Qingdao University, Yantai, Shandong 264400, P.R. China.

ABSTRACT

Nine cases of infiltrating cribriform carcinoma (ICC) of the breast are reported and the clinicopathological features, particularly the imaging findings, are analyzed in the present study. Sonograms revealed that all masses exhibited a hypoechoic internal echo texture (9/9) and that a number of masses presented with an irregular shape (8/9), obscure boundary (5/9), partially microlobulated (5/9) or well-circumscribed (4/9) margins, and an inhomogeneous echo (8/9). Mammographic imaging revealed increased radiological density masses (6/8), and sand-like calcification was not observed in all patients. In two patients, the tumors were mammographically occult. Magnetic resonance imaging performed on one patient revealed a slightly high signal intensity on fat-saturated T1- and T2-weighted images. Following contrast enhancement, a homogeneous early enhancement was revealed with a quick ascent and quick descent time-density curve. Immunohistochemistry revealed that all ICCs expressed estrogen receptor and progesterone receptor, but that none were positive for human epidermal growth factor receptor 2. The Ki-67 labeling index was 3.75% (range, 2-5%) in the tumor tissue. Four patients were treated with mastectomy and the others with breast-conserving surgery. Six clinically node-negative patients underwent sentinel lymph node biopsy; three then received axillary lymph node dissection. Following surgery, three patients received adjuvant chemotherapy, radiotherapy and hormonal therapy, respectively. With a median follow-up time of 38 months (range, 4-70 months), one patient developed local recurrence following breast-conserving surgery; axillary lymph nodes and distant metastases were not observed. This study confirms that this type of carcinoma has unique biological characteristics and a favorable prognosis, but that it remains possible to experience local recurrence.

No MeSH data available.


Related in: MedlinePlus