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Association between Environmental Dioxin-Related Toxicants Exposure and Adverse Pregnancy Outcome: Systematic Review and Meta-Analysis.

Pan X, Liu X, Li X, Niu N, Yin X, Li N, Yu Z - Int J Fertil Steril (2015)

Bottom Line: Dioxin-related compounds are associated with teratogenic and mutagenic risks in laboratory animals, and result in adverse pregnancy outcomes.However, there were inconsistent results in epidemiology studies.In either cohort studies (I(2)=0.89, p<0.0001) or case control studies (I(2)=0.69, p=0.02), significant heterogeneity of risk estimates were observed.

View Article: PubMed Central - PubMed

Affiliation: College of Public Health, Zhengzhou University, Zhengzhou, China ; Medical College, Henan University of Science and Technology, Luoyang, China.

ABSTRACT
Dioxin-related compounds are associated with teratogenic and mutagenic risks in laboratory animals, and result in adverse pregnancy outcomes. However, there were inconsistent results in epidemiology studies. In view of this difference, we conducted a systematic review and meta-analysis to examine this association and to assess the heterogeneity among studies. Comprehensive literature searches were performed to search for relevant articles published in English up to 15 May 2012. In total, we identified 15 studies which included 9 cohort and 6 case control studies. The Cochrane Q test and index of heterogeneity (I(2)) were used to evaluate heterogeneity. In either cohort studies (I(2)=0.89, p<0.0001) or case control studies (I(2)=0.69, p=0.02), significant heterogeneity of risk estimates were observed. Subgroup analyses found no significant increased risk of adverse pregnancy outcome with air dioxin-related compounds exposure (RR=0.99, 95% CI:0.85-1.16), no significant increased risk of spontaneous abortion (SAB) with exposure to food dioxin-related compounds (RR=1.05, 95% CI:0.80-1.37), higher significant risks of low birth weight (LBW) with exposure to food dioxin-related compounds (RR=1.55, 95% CI:1.24-1.94), and higher significant risks of birth defects with maternal solid contaminants dioxin exposure (OR=1.24, 95% CI:1.19-1.29). In conclusion, more evidences are needed to confirm the association between environmental dioxin-related compounds exposure and pregnancy outcome.

No MeSH data available.


Related in: MedlinePlus

A flow diagram for selecting studies and specific exclusion reasons in this meta-analysis.
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Figure 1: A flow diagram for selecting studies and specific exclusion reasons in this meta-analysis.

Mentions: This review included 15 studies. Among the 15studies identified, there were 9 cohort and 6 case–control studies. The results of the searches and thearticles selection log are reported in figure 1. Thecharacteristics of the 15 studies which includedfirst author, year of publication, country, study period,characteristics of the study population, exposuredefinition/data source and measurement, exposedlevel, case ascertainment, and study resultsare reported in tables 1 and 2.


Association between Environmental Dioxin-Related Toxicants Exposure and Adverse Pregnancy Outcome: Systematic Review and Meta-Analysis.

Pan X, Liu X, Li X, Niu N, Yin X, Li N, Yu Z - Int J Fertil Steril (2015)

A flow diagram for selecting studies and specific exclusion reasons in this meta-analysis.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4355921&req=5

Figure 1: A flow diagram for selecting studies and specific exclusion reasons in this meta-analysis.
Mentions: This review included 15 studies. Among the 15studies identified, there were 9 cohort and 6 case–control studies. The results of the searches and thearticles selection log are reported in figure 1. Thecharacteristics of the 15 studies which includedfirst author, year of publication, country, study period,characteristics of the study population, exposuredefinition/data source and measurement, exposedlevel, case ascertainment, and study resultsare reported in tables 1 and 2.

Bottom Line: Dioxin-related compounds are associated with teratogenic and mutagenic risks in laboratory animals, and result in adverse pregnancy outcomes.However, there were inconsistent results in epidemiology studies.In either cohort studies (I(2)=0.89, p<0.0001) or case control studies (I(2)=0.69, p=0.02), significant heterogeneity of risk estimates were observed.

View Article: PubMed Central - PubMed

Affiliation: College of Public Health, Zhengzhou University, Zhengzhou, China ; Medical College, Henan University of Science and Technology, Luoyang, China.

ABSTRACT
Dioxin-related compounds are associated with teratogenic and mutagenic risks in laboratory animals, and result in adverse pregnancy outcomes. However, there were inconsistent results in epidemiology studies. In view of this difference, we conducted a systematic review and meta-analysis to examine this association and to assess the heterogeneity among studies. Comprehensive literature searches were performed to search for relevant articles published in English up to 15 May 2012. In total, we identified 15 studies which included 9 cohort and 6 case control studies. The Cochrane Q test and index of heterogeneity (I(2)) were used to evaluate heterogeneity. In either cohort studies (I(2)=0.89, p<0.0001) or case control studies (I(2)=0.69, p=0.02), significant heterogeneity of risk estimates were observed. Subgroup analyses found no significant increased risk of adverse pregnancy outcome with air dioxin-related compounds exposure (RR=0.99, 95% CI:0.85-1.16), no significant increased risk of spontaneous abortion (SAB) with exposure to food dioxin-related compounds (RR=1.05, 95% CI:0.80-1.37), higher significant risks of low birth weight (LBW) with exposure to food dioxin-related compounds (RR=1.55, 95% CI:1.24-1.94), and higher significant risks of birth defects with maternal solid contaminants dioxin exposure (OR=1.24, 95% CI:1.19-1.29). In conclusion, more evidences are needed to confirm the association between environmental dioxin-related compounds exposure and pregnancy outcome.

No MeSH data available.


Related in: MedlinePlus