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Formulation and evaluation of mouth disintegrating tablets of atenolol and atorvastatin.

Sarfraz RM, Khan HU, Mahmood A, Ahmad M, Maheen S, Sher M - Indian J Pharm Sci (2015 Jan-Feb)

Bottom Line: Precompression studies like bulk density, tapped density, angle of repose, Carr's compressibility index, Hausner's ratio and compatibility studies such as Fourier transform infrared spectroscopy and differential scanning calorimetry were performed.Finally results were statistically analyzed by the application of one way ANOVA test.Formulation F13 containing Kyron-T134 (6%) and croscarmellose sodium (2%) was found to be the best among all fifteen formulations prepared in all aspects evaluated.

View Article: PubMed Central - PubMed

Affiliation: Faculty of Pharmacy, Islamia University of Bahawalpur, Bahawalpur, 63100, Punjab, Pakistan.

ABSTRACT
In this study, mouth-disintegrating tablets of atenolol and atorvastatin combination were formulated using superdisintegrants to impart fast disintegration. Fifteen formulations were prepared based on different concentrations of two superdisintegrants, croscarmellose sodium and Kyron-T134. Three different techniques such as direct compression, effervescent and sublimation were used to study the effect of manufacturing processes, nature and concentration of superdisintegrants on various features of these tablets. Five formulations were made using each method. Precompression studies like bulk density, tapped density, angle of repose, Carr's compressibility index, Hausner's ratio and compatibility studies such as Fourier transform infrared spectroscopy and differential scanning calorimetry were performed. Various features such as hardness, thickness, diameter, weight variation, friability, disintegration time, dissolution studies, wetting time, wetting volume, water absorption ratio, modified disintegration, uniformity of contents and stability were evaluated. Finally results were statistically analyzed by the application of one way ANOVA test. Formulation F13 containing Kyron-T134 (6%) and croscarmellose sodium (2%) was found to be the best among all fifteen formulations prepared in all aspects evaluated. Sublimation method is found to be the best among three methods of preparation used.

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Mentions: The release studies of both drugs were measured by using UV/Vis spectrophotometer. The results had shown that the release of atenolol was in the range of 97 to 101% for 15 formulations in 12 min. Atorvastatin release was in the range of 96 to 100.5% (fig. 3). These results had shown that atenolol release is more as compared to atorvastatin. Wetting volume was 10 to 26 ml. Water absorption ratio was up to 1.55 which shown that tablets can absorb water more than 1.5 times of its weight as shown in Table 4.


Formulation and evaluation of mouth disintegrating tablets of atenolol and atorvastatin.

Sarfraz RM, Khan HU, Mahmood A, Ahmad M, Maheen S, Sher M - Indian J Pharm Sci (2015 Jan-Feb)

© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4355887&req=5

Mentions: The release studies of both drugs were measured by using UV/Vis spectrophotometer. The results had shown that the release of atenolol was in the range of 97 to 101% for 15 formulations in 12 min. Atorvastatin release was in the range of 96 to 100.5% (fig. 3). These results had shown that atenolol release is more as compared to atorvastatin. Wetting volume was 10 to 26 ml. Water absorption ratio was up to 1.55 which shown that tablets can absorb water more than 1.5 times of its weight as shown in Table 4.

Bottom Line: Precompression studies like bulk density, tapped density, angle of repose, Carr's compressibility index, Hausner's ratio and compatibility studies such as Fourier transform infrared spectroscopy and differential scanning calorimetry were performed.Finally results were statistically analyzed by the application of one way ANOVA test.Formulation F13 containing Kyron-T134 (6%) and croscarmellose sodium (2%) was found to be the best among all fifteen formulations prepared in all aspects evaluated.

View Article: PubMed Central - PubMed

Affiliation: Faculty of Pharmacy, Islamia University of Bahawalpur, Bahawalpur, 63100, Punjab, Pakistan.

ABSTRACT
In this study, mouth-disintegrating tablets of atenolol and atorvastatin combination were formulated using superdisintegrants to impart fast disintegration. Fifteen formulations were prepared based on different concentrations of two superdisintegrants, croscarmellose sodium and Kyron-T134. Three different techniques such as direct compression, effervescent and sublimation were used to study the effect of manufacturing processes, nature and concentration of superdisintegrants on various features of these tablets. Five formulations were made using each method. Precompression studies like bulk density, tapped density, angle of repose, Carr's compressibility index, Hausner's ratio and compatibility studies such as Fourier transform infrared spectroscopy and differential scanning calorimetry were performed. Various features such as hardness, thickness, diameter, weight variation, friability, disintegration time, dissolution studies, wetting time, wetting volume, water absorption ratio, modified disintegration, uniformity of contents and stability were evaluated. Finally results were statistically analyzed by the application of one way ANOVA test. Formulation F13 containing Kyron-T134 (6%) and croscarmellose sodium (2%) was found to be the best among all fifteen formulations prepared in all aspects evaluated. Sublimation method is found to be the best among three methods of preparation used.

No MeSH data available.


Related in: MedlinePlus