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Formulation and evaluation of mouth disintegrating tablets of atenolol and atorvastatin.

Sarfraz RM, Khan HU, Mahmood A, Ahmad M, Maheen S, Sher M - Indian J Pharm Sci (2015 Jan-Feb)

Bottom Line: Precompression studies like bulk density, tapped density, angle of repose, Carr's compressibility index, Hausner's ratio and compatibility studies such as Fourier transform infrared spectroscopy and differential scanning calorimetry were performed.Finally results were statistically analyzed by the application of one way ANOVA test.Formulation F13 containing Kyron-T134 (6%) and croscarmellose sodium (2%) was found to be the best among all fifteen formulations prepared in all aspects evaluated.

View Article: PubMed Central - PubMed

Affiliation: Faculty of Pharmacy, Islamia University of Bahawalpur, Bahawalpur, 63100, Punjab, Pakistan.

ABSTRACT
In this study, mouth-disintegrating tablets of atenolol and atorvastatin combination were formulated using superdisintegrants to impart fast disintegration. Fifteen formulations were prepared based on different concentrations of two superdisintegrants, croscarmellose sodium and Kyron-T134. Three different techniques such as direct compression, effervescent and sublimation were used to study the effect of manufacturing processes, nature and concentration of superdisintegrants on various features of these tablets. Five formulations were made using each method. Precompression studies like bulk density, tapped density, angle of repose, Carr's compressibility index, Hausner's ratio and compatibility studies such as Fourier transform infrared spectroscopy and differential scanning calorimetry were performed. Various features such as hardness, thickness, diameter, weight variation, friability, disintegration time, dissolution studies, wetting time, wetting volume, water absorption ratio, modified disintegration, uniformity of contents and stability were evaluated. Finally results were statistically analyzed by the application of one way ANOVA test. Formulation F13 containing Kyron-T134 (6%) and croscarmellose sodium (2%) was found to be the best among all fifteen formulations prepared in all aspects evaluated. Sublimation method is found to be the best among three methods of preparation used.

No MeSH data available.


Related in: MedlinePlus

DSC Spectra of individual components and blends.Differential scanning calorimetric spectra of A. blend of croscarmellose sodium + atenolol + atorvastatin + KyronT134, B. mixture of KyronT134 + croscarmellose sodium, C. croscarmellose sodium alone, D. KyronT134 alone, E. atenolol+atorvastatin mixture, F. atorvastatin and G. atenolol.
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Figure 2: DSC Spectra of individual components and blends.Differential scanning calorimetric spectra of A. blend of croscarmellose sodium + atenolol + atorvastatin + KyronT134, B. mixture of KyronT134 + croscarmellose sodium, C. croscarmellose sodium alone, D. KyronT134 alone, E. atenolol+atorvastatin mixture, F. atorvastatin and G. atenolol.

Mentions: FTIR results showed that there were no interactions between the drugs as well as drugs and superdisintegrants and between the superdisintegrants (fig. 1). DSC study also showed that drugs and excipients had no interactions with each other (fig. 2). Accelerated stability studies had revealed that tablets remained stable for a recommended time period.


Formulation and evaluation of mouth disintegrating tablets of atenolol and atorvastatin.

Sarfraz RM, Khan HU, Mahmood A, Ahmad M, Maheen S, Sher M - Indian J Pharm Sci (2015 Jan-Feb)

DSC Spectra of individual components and blends.Differential scanning calorimetric spectra of A. blend of croscarmellose sodium + atenolol + atorvastatin + KyronT134, B. mixture of KyronT134 + croscarmellose sodium, C. croscarmellose sodium alone, D. KyronT134 alone, E. atenolol+atorvastatin mixture, F. atorvastatin and G. atenolol.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4355887&req=5

Figure 2: DSC Spectra of individual components and blends.Differential scanning calorimetric spectra of A. blend of croscarmellose sodium + atenolol + atorvastatin + KyronT134, B. mixture of KyronT134 + croscarmellose sodium, C. croscarmellose sodium alone, D. KyronT134 alone, E. atenolol+atorvastatin mixture, F. atorvastatin and G. atenolol.
Mentions: FTIR results showed that there were no interactions between the drugs as well as drugs and superdisintegrants and between the superdisintegrants (fig. 1). DSC study also showed that drugs and excipients had no interactions with each other (fig. 2). Accelerated stability studies had revealed that tablets remained stable for a recommended time period.

Bottom Line: Precompression studies like bulk density, tapped density, angle of repose, Carr's compressibility index, Hausner's ratio and compatibility studies such as Fourier transform infrared spectroscopy and differential scanning calorimetry were performed.Finally results were statistically analyzed by the application of one way ANOVA test.Formulation F13 containing Kyron-T134 (6%) and croscarmellose sodium (2%) was found to be the best among all fifteen formulations prepared in all aspects evaluated.

View Article: PubMed Central - PubMed

Affiliation: Faculty of Pharmacy, Islamia University of Bahawalpur, Bahawalpur, 63100, Punjab, Pakistan.

ABSTRACT
In this study, mouth-disintegrating tablets of atenolol and atorvastatin combination were formulated using superdisintegrants to impart fast disintegration. Fifteen formulations were prepared based on different concentrations of two superdisintegrants, croscarmellose sodium and Kyron-T134. Three different techniques such as direct compression, effervescent and sublimation were used to study the effect of manufacturing processes, nature and concentration of superdisintegrants on various features of these tablets. Five formulations were made using each method. Precompression studies like bulk density, tapped density, angle of repose, Carr's compressibility index, Hausner's ratio and compatibility studies such as Fourier transform infrared spectroscopy and differential scanning calorimetry were performed. Various features such as hardness, thickness, diameter, weight variation, friability, disintegration time, dissolution studies, wetting time, wetting volume, water absorption ratio, modified disintegration, uniformity of contents and stability were evaluated. Finally results were statistically analyzed by the application of one way ANOVA test. Formulation F13 containing Kyron-T134 (6%) and croscarmellose sodium (2%) was found to be the best among all fifteen formulations prepared in all aspects evaluated. Sublimation method is found to be the best among three methods of preparation used.

No MeSH data available.


Related in: MedlinePlus