Limits...
Single and dual drug release patterns from shellac wax-lutrol matrix tablets fabricated with fusion and molding techniques.

Phaechamud T, Choncheewa C - Indian J Pharm Sci (2015 Jan-Feb)

Bottom Line: The gel network from high content of Lutrol was hexagonal which was a dense and more compact structure than the other structures found when low amounts of Lutrol were present in the formula.Therefore, the formulae with high content of Lutrol could prolong drug release more efficiently than those containing low content of Lutrol.Sustainable dual drug release was also obtained from these developed matrix tablets.

View Article: PubMed Central - PubMed

Affiliation: Department of Pharmaceutical Technology, Faculty of Pharmacy, Silpakorn University, Nakorn Pathom 73000, Thailand.

ABSTRACT
The objective of this investigation was to prepare the shellac wax matrix tablets by fusion and molding technique incorporated with Lutrol in different ratios to modify the hydrophobicity of matrix tablet. The matrix tablets with single drug were loaded either with propranolol hydrochloride or hydrochlorothiazide as hydrophilic and hydrophobic model drugs, and a dual drug formula was also prepared. The single and dual drug release patterns were studied in a dissolution apparatus using distilled water as medium. Propranolol hydrochloride released from matrix was easier than hydrochlorothiazide. Drug release from shellac wax matrix could be enhanced by incorporation of Lutrol. However retardation of drug release from some matrix tablets was evident for the systems that could form dispersion in the dissolution medium. The gel network from high content of Lutrol was hexagonal which was a dense and more compact structure than the other structures found when low amounts of Lutrol were present in the formula. Therefore, the formulae with high content of Lutrol could prolong drug release more efficiently than those containing low content of Lutrol. Hence shellac wax matrix could modulate the drug release with the addition of Lutrol. Sustainable dual drug release was also obtained from these developed matrix tablets. Thus shellac wax-Lutrol component could be used as a potential matrix tablet prepared with fusion and molding technique with excellent controlled drug release.

No MeSH data available.


Calculated SFE of molded tablets.Calculated SFE of molded tablets containing various ratios of L:S.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
getmorefigures.php?uid=PMC4355884&req=5

Figure 4: Calculated SFE of molded tablets.Calculated SFE of molded tablets containing various ratios of L:S.

Mentions: The contact angle on surface of molded tablet was used to determine SFE for determination of the wettability. The higher SFE indicates the higher polarity hence the system with high SFE could be easily spread with the fluid such as dissolution medium. In the other meaning, the low of contact angle could also indicate the easily spreading or miscible well of the medium on the prepared matrix. Contact angle of tablets loaded with the combined model drugs at various ratios of L:S are shown in fig. 3. The high contact angle was found when the ratio was 0:10 L:S. The other formula showed a small value with no difference of contact angle in each formula. Therefore, it could conclude that the distilled water hardly penetrated or spread on the surface of 0:10 L:S tablet because of its high hydrophobicity, but the distilled water could be easier spread on the surface of other formula. The SFE (fig. 4) showed the trend relevant with those of their contact angle which the high contact angle caused the low SFE indicating the lower polarity of the surface. Increment of L tended to increase the SFE. The SFE increased rapidly in 3:7 L:S then it seem constant but slightly decreased in the 7:3 L:S.


Single and dual drug release patterns from shellac wax-lutrol matrix tablets fabricated with fusion and molding techniques.

Phaechamud T, Choncheewa C - Indian J Pharm Sci (2015 Jan-Feb)

Calculated SFE of molded tablets.Calculated SFE of molded tablets containing various ratios of L:S.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4355884&req=5

Figure 4: Calculated SFE of molded tablets.Calculated SFE of molded tablets containing various ratios of L:S.
Mentions: The contact angle on surface of molded tablet was used to determine SFE for determination of the wettability. The higher SFE indicates the higher polarity hence the system with high SFE could be easily spread with the fluid such as dissolution medium. In the other meaning, the low of contact angle could also indicate the easily spreading or miscible well of the medium on the prepared matrix. Contact angle of tablets loaded with the combined model drugs at various ratios of L:S are shown in fig. 3. The high contact angle was found when the ratio was 0:10 L:S. The other formula showed a small value with no difference of contact angle in each formula. Therefore, it could conclude that the distilled water hardly penetrated or spread on the surface of 0:10 L:S tablet because of its high hydrophobicity, but the distilled water could be easier spread on the surface of other formula. The SFE (fig. 4) showed the trend relevant with those of their contact angle which the high contact angle caused the low SFE indicating the lower polarity of the surface. Increment of L tended to increase the SFE. The SFE increased rapidly in 3:7 L:S then it seem constant but slightly decreased in the 7:3 L:S.

Bottom Line: The gel network from high content of Lutrol was hexagonal which was a dense and more compact structure than the other structures found when low amounts of Lutrol were present in the formula.Therefore, the formulae with high content of Lutrol could prolong drug release more efficiently than those containing low content of Lutrol.Sustainable dual drug release was also obtained from these developed matrix tablets.

View Article: PubMed Central - PubMed

Affiliation: Department of Pharmaceutical Technology, Faculty of Pharmacy, Silpakorn University, Nakorn Pathom 73000, Thailand.

ABSTRACT
The objective of this investigation was to prepare the shellac wax matrix tablets by fusion and molding technique incorporated with Lutrol in different ratios to modify the hydrophobicity of matrix tablet. The matrix tablets with single drug were loaded either with propranolol hydrochloride or hydrochlorothiazide as hydrophilic and hydrophobic model drugs, and a dual drug formula was also prepared. The single and dual drug release patterns were studied in a dissolution apparatus using distilled water as medium. Propranolol hydrochloride released from matrix was easier than hydrochlorothiazide. Drug release from shellac wax matrix could be enhanced by incorporation of Lutrol. However retardation of drug release from some matrix tablets was evident for the systems that could form dispersion in the dissolution medium. The gel network from high content of Lutrol was hexagonal which was a dense and more compact structure than the other structures found when low amounts of Lutrol were present in the formula. Therefore, the formulae with high content of Lutrol could prolong drug release more efficiently than those containing low content of Lutrol. Hence shellac wax matrix could modulate the drug release with the addition of Lutrol. Sustainable dual drug release was also obtained from these developed matrix tablets. Thus shellac wax-Lutrol component could be used as a potential matrix tablet prepared with fusion and molding technique with excellent controlled drug release.

No MeSH data available.