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Microwave-assisted Extraction of Alantolactone and Isoalantolactone from Inula helenium.

Zhao YM, Wang J, Liu HB, Guo CY, Zhang WM - Indian J Pharm Sci (2015 Jan-Feb)

Bottom Line: Microwave-assisted extraction was used for the extraction of alantolactone and isoalantolactone from Inula helenium.The optimal extracting process of the alantolactone and isoalantolactone from the root of the Inula helenium was 1 g plant sample (sifted through 140 mesh) mixed with 15 ml of 80% ethanol solution, microwave radiation 120 s at 50°.Under these optimal conditions, the yield of alantolactone and isoalantolactone was 31.83±2.08 mg/g and 21.25±1.37 mg/g, respectively.

View Article: PubMed Central - PubMed

Affiliation: Department of Pharmacy, Hebei North University, No.11 Zuanshi South Road, Zhangjiakou-075 000, China.

ABSTRACT
Microwave-assisted extraction was used for the extraction of alantolactone and isoalantolactone from Inula helenium. Effects of various experimental factors including ethanol concentration, particle size, microwave radiation time, the ratio of material to liquid and extraction temperature on yield of alantolactone and isoalantolactone were evaluated. The optimal extracting process of the alantolactone and isoalantolactone from the root of the Inula helenium was 1 g plant sample (sifted through 140 mesh) mixed with 15 ml of 80% ethanol solution, microwave radiation 120 s at 50°. Under these optimal conditions, the yield of alantolactone and isoalantolactone was 31.83±2.08 mg/g and 21.25±1.37 mg/g, respectively. Compared with heat reflux extraction, ultrasound-assisted extraction, microwave-assisted extraction was more efficient and timesaving for the extraction of alantolactone and isoalantolactone from Inula helenium.

No MeSH data available.


Related in: MedlinePlus

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Mentions: In order to elucidate the influence of MAE temperature on yield of alantolactone and isoalantolactone, five grams powder was mixed with ethanol solution at various temperature (30, 40, 50, 60 and 70°, respectively) for 120 s. fig. 5 showed that the yield of alantolactone and isoalantolactone was increased with the increased of temperature. It meant that the solubility of alantolactone and isoalantolactone increased by elevated temperature. Meanwhile, with the increased of temperature, the diffusion of the active ingredients will accelerate, the solvent viscosity and surface tension decreased, which contribute to the sample wetting and matrix penetration. However, there was no statistical difference on the yield of alantolactone and isoalantolactone among 50, 60 and 70°. Thus, the MAE temperature of 50° was selected as the extraction temperature.


Microwave-assisted Extraction of Alantolactone and Isoalantolactone from Inula helenium.

Zhao YM, Wang J, Liu HB, Guo CY, Zhang WM - Indian J Pharm Sci (2015 Jan-Feb)

© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4355875&req=5

Mentions: In order to elucidate the influence of MAE temperature on yield of alantolactone and isoalantolactone, five grams powder was mixed with ethanol solution at various temperature (30, 40, 50, 60 and 70°, respectively) for 120 s. fig. 5 showed that the yield of alantolactone and isoalantolactone was increased with the increased of temperature. It meant that the solubility of alantolactone and isoalantolactone increased by elevated temperature. Meanwhile, with the increased of temperature, the diffusion of the active ingredients will accelerate, the solvent viscosity and surface tension decreased, which contribute to the sample wetting and matrix penetration. However, there was no statistical difference on the yield of alantolactone and isoalantolactone among 50, 60 and 70°. Thus, the MAE temperature of 50° was selected as the extraction temperature.

Bottom Line: Microwave-assisted extraction was used for the extraction of alantolactone and isoalantolactone from Inula helenium.The optimal extracting process of the alantolactone and isoalantolactone from the root of the Inula helenium was 1 g plant sample (sifted through 140 mesh) mixed with 15 ml of 80% ethanol solution, microwave radiation 120 s at 50°.Under these optimal conditions, the yield of alantolactone and isoalantolactone was 31.83±2.08 mg/g and 21.25±1.37 mg/g, respectively.

View Article: PubMed Central - PubMed

Affiliation: Department of Pharmacy, Hebei North University, No.11 Zuanshi South Road, Zhangjiakou-075 000, China.

ABSTRACT
Microwave-assisted extraction was used for the extraction of alantolactone and isoalantolactone from Inula helenium. Effects of various experimental factors including ethanol concentration, particle size, microwave radiation time, the ratio of material to liquid and extraction temperature on yield of alantolactone and isoalantolactone were evaluated. The optimal extracting process of the alantolactone and isoalantolactone from the root of the Inula helenium was 1 g plant sample (sifted through 140 mesh) mixed with 15 ml of 80% ethanol solution, microwave radiation 120 s at 50°. Under these optimal conditions, the yield of alantolactone and isoalantolactone was 31.83±2.08 mg/g and 21.25±1.37 mg/g, respectively. Compared with heat reflux extraction, ultrasound-assisted extraction, microwave-assisted extraction was more efficient and timesaving for the extraction of alantolactone and isoalantolactone from Inula helenium.

No MeSH data available.


Related in: MedlinePlus