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Microwave-assisted Extraction of Alantolactone and Isoalantolactone from Inula helenium.

Zhao YM, Wang J, Liu HB, Guo CY, Zhang WM - Indian J Pharm Sci (2015 Jan-Feb)

Bottom Line: Microwave-assisted extraction was used for the extraction of alantolactone and isoalantolactone from Inula helenium.The optimal extracting process of the alantolactone and isoalantolactone from the root of the Inula helenium was 1 g plant sample (sifted through 140 mesh) mixed with 15 ml of 80% ethanol solution, microwave radiation 120 s at 50°.Under these optimal conditions, the yield of alantolactone and isoalantolactone was 31.83±2.08 mg/g and 21.25±1.37 mg/g, respectively.

View Article: PubMed Central - PubMed

Affiliation: Department of Pharmacy, Hebei North University, No.11 Zuanshi South Road, Zhangjiakou-075 000, China.

ABSTRACT
Microwave-assisted extraction was used for the extraction of alantolactone and isoalantolactone from Inula helenium. Effects of various experimental factors including ethanol concentration, particle size, microwave radiation time, the ratio of material to liquid and extraction temperature on yield of alantolactone and isoalantolactone were evaluated. The optimal extracting process of the alantolactone and isoalantolactone from the root of the Inula helenium was 1 g plant sample (sifted through 140 mesh) mixed with 15 ml of 80% ethanol solution, microwave radiation 120 s at 50°. Under these optimal conditions, the yield of alantolactone and isoalantolactone was 31.83±2.08 mg/g and 21.25±1.37 mg/g, respectively. Compared with heat reflux extraction, ultrasound-assisted extraction, microwave-assisted extraction was more efficient and timesaving for the extraction of alantolactone and isoalantolactone from Inula helenium.

No MeSH data available.


Related in: MedlinePlus

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Mentions: Under the optimal condition as mentioned above, effect of the ratio of material to liquid (1:5, 1:10, 1:15, 1:20, 1:30, g/ml) on yield of alantolactone and isoalantolactone was evaluated with the extraction temperature at 50° in the present study. As it shown in fig. 4, the extraction yield of alantolactone and isoalantolactone was first increased then reached a maximum (31.57 and 20.68 mg/g respectively) when the ratio was 15:1. However, there were nearly unchanged when the ratio increased. This may be caused by reducing the extraction solvent, which would reduce the surface area for solvent to penetrate plant tissue and to solubilize the target compounds that was not beneficial for the extracting process. On the contrary, a larger volume of solvent caused sufficient swelling of material, but inadequate agitation of solvent may occurred during irradiation. For this reason, the solid/liquid ratio of 1:15 was appropriate to reach the high yield of alantolactone and isoalantolactone.


Microwave-assisted Extraction of Alantolactone and Isoalantolactone from Inula helenium.

Zhao YM, Wang J, Liu HB, Guo CY, Zhang WM - Indian J Pharm Sci (2015 Jan-Feb)

© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4355875&req=5

Mentions: Under the optimal condition as mentioned above, effect of the ratio of material to liquid (1:5, 1:10, 1:15, 1:20, 1:30, g/ml) on yield of alantolactone and isoalantolactone was evaluated with the extraction temperature at 50° in the present study. As it shown in fig. 4, the extraction yield of alantolactone and isoalantolactone was first increased then reached a maximum (31.57 and 20.68 mg/g respectively) when the ratio was 15:1. However, there were nearly unchanged when the ratio increased. This may be caused by reducing the extraction solvent, which would reduce the surface area for solvent to penetrate plant tissue and to solubilize the target compounds that was not beneficial for the extracting process. On the contrary, a larger volume of solvent caused sufficient swelling of material, but inadequate agitation of solvent may occurred during irradiation. For this reason, the solid/liquid ratio of 1:15 was appropriate to reach the high yield of alantolactone and isoalantolactone.

Bottom Line: Microwave-assisted extraction was used for the extraction of alantolactone and isoalantolactone from Inula helenium.The optimal extracting process of the alantolactone and isoalantolactone from the root of the Inula helenium was 1 g plant sample (sifted through 140 mesh) mixed with 15 ml of 80% ethanol solution, microwave radiation 120 s at 50°.Under these optimal conditions, the yield of alantolactone and isoalantolactone was 31.83±2.08 mg/g and 21.25±1.37 mg/g, respectively.

View Article: PubMed Central - PubMed

Affiliation: Department of Pharmacy, Hebei North University, No.11 Zuanshi South Road, Zhangjiakou-075 000, China.

ABSTRACT
Microwave-assisted extraction was used for the extraction of alantolactone and isoalantolactone from Inula helenium. Effects of various experimental factors including ethanol concentration, particle size, microwave radiation time, the ratio of material to liquid and extraction temperature on yield of alantolactone and isoalantolactone were evaluated. The optimal extracting process of the alantolactone and isoalantolactone from the root of the Inula helenium was 1 g plant sample (sifted through 140 mesh) mixed with 15 ml of 80% ethanol solution, microwave radiation 120 s at 50°. Under these optimal conditions, the yield of alantolactone and isoalantolactone was 31.83±2.08 mg/g and 21.25±1.37 mg/g, respectively. Compared with heat reflux extraction, ultrasound-assisted extraction, microwave-assisted extraction was more efficient and timesaving for the extraction of alantolactone and isoalantolactone from Inula helenium.

No MeSH data available.


Related in: MedlinePlus