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Autologous bone marrow-derived cells in the treatment of liver disease patients.

AlAhmari LS, AlShenaifi JY, AlAnazi RA, Abdo AA - Saudi J Gastroenterol (2015 Jan-Feb)

Bottom Line: Autologous BM-derived cells have no graft rejection, have the capability of regeneration and self-renewal, and are multipotent stem cells that can differentiate into a variety of cell types which include hepatocytes.The pathway from BM-derived cell to hepatocyte is well documented.The present review summarizes the delivery routes of BM-derived cells to the liver, the evidences of engraftment of BM-derived cells in the liver, and the possible mechanisms of BM-derived cells in liver repair and regeneration, and finally, updates the clinical applications.

View Article: PubMed Central - PubMed

Affiliation: Liver Disease Research Center, College of Medicine, King Saud University, Riyadh, Saudi Arabia.

ABSTRACT
Liver transplantation is universally accepted as a "cure" procedure, and yet is not universally applicable for the treatment of end-stage liver diseases (ESLD) because of the shortage of donors, operative complications, risk of rejection, and high cost. Bioartificial liver device is an option to temporarily improve the liver function and to bridge the patients to liver transplantation. However, bioartificial liver device has many problems in clinical application, such as hepatocyte allograft rejection and maintenance of hepatocyte viability and function. Another therapeutic option is stem cell transplantation. There are two broad types of stem cells: Embryonic stem cells and adult stem cells. The latter are sourced from bone marrow (BM), adipose tissue, and blood. This review will concentrate on BM-derived cells. BM-derived cell transplantation, although not ideal, is theoretically an optimal modality for the treatment of ESLD. Autologous BM-derived cells have no graft rejection, have the capability of regeneration and self-renewal, and are multipotent stem cells that can differentiate into a variety of cell types which include hepatocytes. The pathway from BM-derived cell to hepatocyte is well documented. The present review summarizes the delivery routes of BM-derived cells to the liver, the evidences of engraftment of BM-derived cells in the liver, and the possible mechanisms of BM-derived cells in liver repair and regeneration, and finally, updates the clinical applications.

No MeSH data available.


Related in: MedlinePlus

Role and mechanism of bone marrow stem cells in liver repair and regeneration. VEGF, vascular endothelial growth factor; MMP-9, matrix metalloproteinase-9; IL-6, interleukin-6; GFs, growth factors
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Figure 1: Role and mechanism of bone marrow stem cells in liver repair and regeneration. VEGF, vascular endothelial growth factor; MMP-9, matrix metalloproteinase-9; IL-6, interleukin-6; GFs, growth factors

Mentions: There are four aspects of the effect of BM SCs on liver repair and regeneration: Hepatocyte differentiation, modulation of immunity and anti-inflammation, anti-oxidative stress and anti-apoptosis, and improvement of blood supply and anti-fibrogenesis [Figure 1].


Autologous bone marrow-derived cells in the treatment of liver disease patients.

AlAhmari LS, AlShenaifi JY, AlAnazi RA, Abdo AA - Saudi J Gastroenterol (2015 Jan-Feb)

Role and mechanism of bone marrow stem cells in liver repair and regeneration. VEGF, vascular endothelial growth factor; MMP-9, matrix metalloproteinase-9; IL-6, interleukin-6; GFs, growth factors
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4355864&req=5

Figure 1: Role and mechanism of bone marrow stem cells in liver repair and regeneration. VEGF, vascular endothelial growth factor; MMP-9, matrix metalloproteinase-9; IL-6, interleukin-6; GFs, growth factors
Mentions: There are four aspects of the effect of BM SCs on liver repair and regeneration: Hepatocyte differentiation, modulation of immunity and anti-inflammation, anti-oxidative stress and anti-apoptosis, and improvement of blood supply and anti-fibrogenesis [Figure 1].

Bottom Line: Autologous BM-derived cells have no graft rejection, have the capability of regeneration and self-renewal, and are multipotent stem cells that can differentiate into a variety of cell types which include hepatocytes.The pathway from BM-derived cell to hepatocyte is well documented.The present review summarizes the delivery routes of BM-derived cells to the liver, the evidences of engraftment of BM-derived cells in the liver, and the possible mechanisms of BM-derived cells in liver repair and regeneration, and finally, updates the clinical applications.

View Article: PubMed Central - PubMed

Affiliation: Liver Disease Research Center, College of Medicine, King Saud University, Riyadh, Saudi Arabia.

ABSTRACT
Liver transplantation is universally accepted as a "cure" procedure, and yet is not universally applicable for the treatment of end-stage liver diseases (ESLD) because of the shortage of donors, operative complications, risk of rejection, and high cost. Bioartificial liver device is an option to temporarily improve the liver function and to bridge the patients to liver transplantation. However, bioartificial liver device has many problems in clinical application, such as hepatocyte allograft rejection and maintenance of hepatocyte viability and function. Another therapeutic option is stem cell transplantation. There are two broad types of stem cells: Embryonic stem cells and adult stem cells. The latter are sourced from bone marrow (BM), adipose tissue, and blood. This review will concentrate on BM-derived cells. BM-derived cell transplantation, although not ideal, is theoretically an optimal modality for the treatment of ESLD. Autologous BM-derived cells have no graft rejection, have the capability of regeneration and self-renewal, and are multipotent stem cells that can differentiate into a variety of cell types which include hepatocytes. The pathway from BM-derived cell to hepatocyte is well documented. The present review summarizes the delivery routes of BM-derived cells to the liver, the evidences of engraftment of BM-derived cells in the liver, and the possible mechanisms of BM-derived cells in liver repair and regeneration, and finally, updates the clinical applications.

No MeSH data available.


Related in: MedlinePlus