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Diarrheagenic Escherichia coli phylogroups are associated with antibiotic resistance and duration of diarrheal episode.

Mosquito S, Pons MJ, Riveros M, Ruiz J, Ochoa TJ - ScientificWorldJournal (2015)

Bottom Line: DEC-control strains were more associated with group A while DEC-diarrhea strains were more associated with group D (P < 0.05).Strains belonging to group D presented significantly higher percentages of multidrug resistance than the rest of the groups (P > 0.01).In summary, DEC-diarrhea strains were more associated with group D than strains from healthy controls.

View Article: PubMed Central - PubMed

Affiliation: Instituto de Medicina Tropical Alexander von Humboldt, Universidad Peruana Cayetano Heredia, Lima 031, Peru.

ABSTRACT
Conventionally, in Escherichia coli, phylogenetic groups A and B1 are associated with commensal strains while B2 and D are associated with extraintestinal strains. The aim of this study was to evaluate diarrheagenic (DEC) and commensal E. coli phylogeny and its association with antibiotic resistance and clinical characteristics of the diarrheal episode. Phylogenetic groups and antibiotic resistance of 369 E. coli strains (commensal strains and DEC from children with or without diarrhea) isolated from Peruvian children <1 year of age were determined by a Clermont triplex PCR and Kirby-Bauer method, respectively. The distribution of the 369 E. coli strains among the 4 phylogenetic groups was A (40%), D (31%), B1 (21%), and B2 (8%). DEC-control strains were more associated with group A while DEC-diarrhea strains were more associated with group D (P < 0.05). There was a tendency (P = 0.06) for higher proportion of persistent diarrhea (≥ 14 days) among severe groups (B2 and D) in comparison with nonsevere groups (A and B1). Strains belonging to group D presented significantly higher percentages of multidrug resistance than the rest of the groups (P > 0.01). In summary, DEC-diarrhea strains were more associated with group D than strains from healthy controls.

No MeSH data available.


Related in: MedlinePlus

Percentages of multiresistance (resistance to 3 or more different antibiotics families) and antibiotic resistance among the four phylogenetic groups A (n = 147), B1 (n = 76), B2 (n = 30), and D (n = 116).
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fig2: Percentages of multiresistance (resistance to 3 or more different antibiotics families) and antibiotic resistance among the four phylogenetic groups A (n = 147), B1 (n = 76), B2 (n = 30), and D (n = 116).

Mentions: Resistance to trimethoprim-sulfamethoxazol, tetracycline, chloramphenicol, and nalidixic acid and multiresistance were significantly different among the four phylogenetic groups (P < 0.05) (Figure 2). In general, B2 and D groups presented higher percentage of antibiotic resistance than A and B1 groups. In the case of multiresistance D group presented significantly higher percentages than the rest of the groups (P < 0.01) (Figure 2).


Diarrheagenic Escherichia coli phylogroups are associated with antibiotic resistance and duration of diarrheal episode.

Mosquito S, Pons MJ, Riveros M, Ruiz J, Ochoa TJ - ScientificWorldJournal (2015)

Percentages of multiresistance (resistance to 3 or more different antibiotics families) and antibiotic resistance among the four phylogenetic groups A (n = 147), B1 (n = 76), B2 (n = 30), and D (n = 116).
© Copyright Policy - open-access
Related In: Results  -  Collection

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getmorefigures.php?uid=PMC4355820&req=5

fig2: Percentages of multiresistance (resistance to 3 or more different antibiotics families) and antibiotic resistance among the four phylogenetic groups A (n = 147), B1 (n = 76), B2 (n = 30), and D (n = 116).
Mentions: Resistance to trimethoprim-sulfamethoxazol, tetracycline, chloramphenicol, and nalidixic acid and multiresistance were significantly different among the four phylogenetic groups (P < 0.05) (Figure 2). In general, B2 and D groups presented higher percentage of antibiotic resistance than A and B1 groups. In the case of multiresistance D group presented significantly higher percentages than the rest of the groups (P < 0.01) (Figure 2).

Bottom Line: DEC-control strains were more associated with group A while DEC-diarrhea strains were more associated with group D (P < 0.05).Strains belonging to group D presented significantly higher percentages of multidrug resistance than the rest of the groups (P > 0.01).In summary, DEC-diarrhea strains were more associated with group D than strains from healthy controls.

View Article: PubMed Central - PubMed

Affiliation: Instituto de Medicina Tropical Alexander von Humboldt, Universidad Peruana Cayetano Heredia, Lima 031, Peru.

ABSTRACT
Conventionally, in Escherichia coli, phylogenetic groups A and B1 are associated with commensal strains while B2 and D are associated with extraintestinal strains. The aim of this study was to evaluate diarrheagenic (DEC) and commensal E. coli phylogeny and its association with antibiotic resistance and clinical characteristics of the diarrheal episode. Phylogenetic groups and antibiotic resistance of 369 E. coli strains (commensal strains and DEC from children with or without diarrhea) isolated from Peruvian children <1 year of age were determined by a Clermont triplex PCR and Kirby-Bauer method, respectively. The distribution of the 369 E. coli strains among the 4 phylogenetic groups was A (40%), D (31%), B1 (21%), and B2 (8%). DEC-control strains were more associated with group A while DEC-diarrhea strains were more associated with group D (P < 0.05). There was a tendency (P = 0.06) for higher proportion of persistent diarrhea (≥ 14 days) among severe groups (B2 and D) in comparison with nonsevere groups (A and B1). Strains belonging to group D presented significantly higher percentages of multidrug resistance than the rest of the groups (P > 0.01). In summary, DEC-diarrhea strains were more associated with group D than strains from healthy controls.

No MeSH data available.


Related in: MedlinePlus