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Evaluation of a topical herbal agent for the promotion of bone healing.

Siu WS, Ko CH, Lam KW, Wat E, Shum WT, Lau CB, Ko KM, Hung LK, Lau DT, Leung PC - Evid Based Complement Alternat Med (2015)

Bottom Line: This indicated its anti-inflammatory effect.However, CDNR did not affect the bone turnover markers in serum of the rats.With its anti-inflammatory and bone formation properties, CDNR is found effective in promoting bone healing.

View Article: PubMed Central - PubMed

Affiliation: Institute of Chinese Medicine, 5/F, The CUHK Hong Kong Jockey Club School of Public Health Building, Prince of Wales Hospital, Shatin, New Territories, Hong Kong ; State Key Laboratory of Phytochemistry and Plant Resources in West China, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong ; Department of Orthopaedics and Traumatology, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong.

ABSTRACT
A topically used Chinese herbal paste, namely, CDNR, was designed to facilitate fracture healing which is usually not addressed in general hospital care. From our in vitro studies, CDNR significantly inhibited the release of nitric oxide from RAW264.7 cells by 51 to 77%. This indicated its anti-inflammatory effect. CDNR also promoted the growth of bone cells by stimulating the proliferation of UMR106 cells up to 18%. It also increased the biomechanical strength of the healing bone in a drill-hole defect rat model by 16.5% significantly. This result revealed its in vivo efficacy on facilitation of bone healing. Furthermore, the detection of the chemical markers of CDNR in the skin and muscle of the treatment area demonstrated its transdermal properties. However, CDNR did not affect the bone turnover markers in serum of the rats. With its anti-inflammatory and bone formation properties, CDNR is found effective in promoting bone healing.

No MeSH data available.


Related in: MedlinePlus

Biomechanical properties of femur with drill-hole bone defect. (a) Yield strength; (b) work done at yield strength. Data are expressed as mean and standard error of mean (error bar). *P < 0.05 versus Control.
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fig3: Biomechanical properties of femur with drill-hole bone defect. (a) Yield strength; (b) work done at yield strength. Data are expressed as mean and standard error of mean (error bar). *P < 0.05 versus Control.

Mentions: Femora with cortical drill holes showed 16.5% higher normalized yield strength (% from the contralateral normal femur) in the CDNR treated group when compared with the Control (P < 0.05) after 42 days of treatment (Figure 3(a)). Similar findings were observed when the total work done at yield point was analyzed. CDNR treated bone showed 13.8% higher energy than the Control to reach the yield point (P < 0.05) (Figure 3(b)). The 4-point bending tests illustrated that the biomechanical properties of the healing at the drill-hole bone defects were improved significantly when the topical herbal paste was applied.


Evaluation of a topical herbal agent for the promotion of bone healing.

Siu WS, Ko CH, Lam KW, Wat E, Shum WT, Lau CB, Ko KM, Hung LK, Lau DT, Leung PC - Evid Based Complement Alternat Med (2015)

Biomechanical properties of femur with drill-hole bone defect. (a) Yield strength; (b) work done at yield strength. Data are expressed as mean and standard error of mean (error bar). *P < 0.05 versus Control.
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4355818&req=5

fig3: Biomechanical properties of femur with drill-hole bone defect. (a) Yield strength; (b) work done at yield strength. Data are expressed as mean and standard error of mean (error bar). *P < 0.05 versus Control.
Mentions: Femora with cortical drill holes showed 16.5% higher normalized yield strength (% from the contralateral normal femur) in the CDNR treated group when compared with the Control (P < 0.05) after 42 days of treatment (Figure 3(a)). Similar findings were observed when the total work done at yield point was analyzed. CDNR treated bone showed 13.8% higher energy than the Control to reach the yield point (P < 0.05) (Figure 3(b)). The 4-point bending tests illustrated that the biomechanical properties of the healing at the drill-hole bone defects were improved significantly when the topical herbal paste was applied.

Bottom Line: This indicated its anti-inflammatory effect.However, CDNR did not affect the bone turnover markers in serum of the rats.With its anti-inflammatory and bone formation properties, CDNR is found effective in promoting bone healing.

View Article: PubMed Central - PubMed

Affiliation: Institute of Chinese Medicine, 5/F, The CUHK Hong Kong Jockey Club School of Public Health Building, Prince of Wales Hospital, Shatin, New Territories, Hong Kong ; State Key Laboratory of Phytochemistry and Plant Resources in West China, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong ; Department of Orthopaedics and Traumatology, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong.

ABSTRACT
A topically used Chinese herbal paste, namely, CDNR, was designed to facilitate fracture healing which is usually not addressed in general hospital care. From our in vitro studies, CDNR significantly inhibited the release of nitric oxide from RAW264.7 cells by 51 to 77%. This indicated its anti-inflammatory effect. CDNR also promoted the growth of bone cells by stimulating the proliferation of UMR106 cells up to 18%. It also increased the biomechanical strength of the healing bone in a drill-hole defect rat model by 16.5% significantly. This result revealed its in vivo efficacy on facilitation of bone healing. Furthermore, the detection of the chemical markers of CDNR in the skin and muscle of the treatment area demonstrated its transdermal properties. However, CDNR did not affect the bone turnover markers in serum of the rats. With its anti-inflammatory and bone formation properties, CDNR is found effective in promoting bone healing.

No MeSH data available.


Related in: MedlinePlus