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Bone morphology in 46 BXD recombinant inbred strains and femur-tibia correlation.

Zhang Y, Huang J, Jiao Y, David V, Kocak M, Roan E, Di'Angelo D, Lu L, Hasty KA, Gu W - ScientificWorldJournal (2015)

Bottom Line: While genetics and gender appear expectedly as the major determinants of bone mass and structure, significant correlations were also observed between femur and tibia.More importantly, positive and negative femur-tibia associations indicated that genetic makeup had an influence on skeletal integrity.We conclude that (a) femur-tibia association in bone morphological properties significantly varies from strain to strain, which may be caused by genetic differences among strains, and (b) strainwise variations were seen in bone mass, bone morphology, and bone microarchitecture along with bone structural property.

View Article: PubMed Central - PubMed

Affiliation: Department of Orthopaedic Surgery and Biomedical Engineering, Campbell Clinic, University of Tennessee Health Science Center, Memphis, TN 38163, USA.

ABSTRACT
We examined the bone properties of BXD recombinant inbred (RI) mice by analyzing femur and tibia and compared their phenotypes of different compartments. 46 BXD RI mouse strains were analyzed including progenitor C57BL/6J (n = 16) and DBA/2J (n = 15) and two first filial generations (D2B6F1 and B6D2F1). Strain differences were observed in bone quality and structural properties (P < 0.05) in each bone profile (whole bone, cortical bone, or trabecular bone). It is well known that skeletal phenotypes are largely affected by genetic determinants and genders, such as bone mineral density (BMD). While genetics and gender appear expectedly as the major determinants of bone mass and structure, significant correlations were also observed between femur and tibia. More importantly, positive and negative femur-tibia associations indicated that genetic makeup had an influence on skeletal integrity. We conclude that (a) femur-tibia association in bone morphological properties significantly varies from strain to strain, which may be caused by genetic differences among strains, and (b) strainwise variations were seen in bone mass, bone morphology, and bone microarchitecture along with bone structural property.

No MeSH data available.


Related in: MedlinePlus

Spearman's rank correlations in trabecular thickness showed strong positive association between femur and tibia. (a) RI Strain BXD48 (r = 0.9, P = 0.04); (b) RI Strain BXD89 (r = 0.75, P = 0.05); (c) RI Strain BXD90 (r = 0.7, P = 0.04).
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fig1: Spearman's rank correlations in trabecular thickness showed strong positive association between femur and tibia. (a) RI Strain BXD48 (r = 0.9, P = 0.04); (b) RI Strain BXD89 (r = 0.75, P = 0.05); (c) RI Strain BXD90 (r = 0.7, P = 0.04).

Mentions: In addition, the degrees of correlations between femur and tibia vary across strains. We observed positive correlations from 0.7 to 1 (in trabecular envelope) and negative correlations from −0.86 to −1 (in whole bone envelope). Even within the same bone phenotype, a variety of correlation coefficients were found across strains. For example, in trabecular thickness, BXD89 and BXD90 revealed significant correlations at 0.75 (P = 0.05) and 0.7 (P = 0.04), respectively, while BXD48 showed a significant correlation of 0.9 (P = 0.04) as seen in Figure 1. This result showed that femur and tibia bone properties could relate to a various extent.


Bone morphology in 46 BXD recombinant inbred strains and femur-tibia correlation.

Zhang Y, Huang J, Jiao Y, David V, Kocak M, Roan E, Di'Angelo D, Lu L, Hasty KA, Gu W - ScientificWorldJournal (2015)

Spearman's rank correlations in trabecular thickness showed strong positive association between femur and tibia. (a) RI Strain BXD48 (r = 0.9, P = 0.04); (b) RI Strain BXD89 (r = 0.75, P = 0.05); (c) RI Strain BXD90 (r = 0.7, P = 0.04).
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4355808&req=5

fig1: Spearman's rank correlations in trabecular thickness showed strong positive association between femur and tibia. (a) RI Strain BXD48 (r = 0.9, P = 0.04); (b) RI Strain BXD89 (r = 0.75, P = 0.05); (c) RI Strain BXD90 (r = 0.7, P = 0.04).
Mentions: In addition, the degrees of correlations between femur and tibia vary across strains. We observed positive correlations from 0.7 to 1 (in trabecular envelope) and negative correlations from −0.86 to −1 (in whole bone envelope). Even within the same bone phenotype, a variety of correlation coefficients were found across strains. For example, in trabecular thickness, BXD89 and BXD90 revealed significant correlations at 0.75 (P = 0.05) and 0.7 (P = 0.04), respectively, while BXD48 showed a significant correlation of 0.9 (P = 0.04) as seen in Figure 1. This result showed that femur and tibia bone properties could relate to a various extent.

Bottom Line: While genetics and gender appear expectedly as the major determinants of bone mass and structure, significant correlations were also observed between femur and tibia.More importantly, positive and negative femur-tibia associations indicated that genetic makeup had an influence on skeletal integrity.We conclude that (a) femur-tibia association in bone morphological properties significantly varies from strain to strain, which may be caused by genetic differences among strains, and (b) strainwise variations were seen in bone mass, bone morphology, and bone microarchitecture along with bone structural property.

View Article: PubMed Central - PubMed

Affiliation: Department of Orthopaedic Surgery and Biomedical Engineering, Campbell Clinic, University of Tennessee Health Science Center, Memphis, TN 38163, USA.

ABSTRACT
We examined the bone properties of BXD recombinant inbred (RI) mice by analyzing femur and tibia and compared their phenotypes of different compartments. 46 BXD RI mouse strains were analyzed including progenitor C57BL/6J (n = 16) and DBA/2J (n = 15) and two first filial generations (D2B6F1 and B6D2F1). Strain differences were observed in bone quality and structural properties (P < 0.05) in each bone profile (whole bone, cortical bone, or trabecular bone). It is well known that skeletal phenotypes are largely affected by genetic determinants and genders, such as bone mineral density (BMD). While genetics and gender appear expectedly as the major determinants of bone mass and structure, significant correlations were also observed between femur and tibia. More importantly, positive and negative femur-tibia associations indicated that genetic makeup had an influence on skeletal integrity. We conclude that (a) femur-tibia association in bone morphological properties significantly varies from strain to strain, which may be caused by genetic differences among strains, and (b) strainwise variations were seen in bone mass, bone morphology, and bone microarchitecture along with bone structural property.

No MeSH data available.


Related in: MedlinePlus