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Cyclooxygenase-2 immunohistochemical expression in serrated polyps of the colon.

Kiedrowski M, Mroz A, Kraszewska E, Rembiszewska A, Felisiak-Golabek A, Kupryjanczyk J, Deptala A, Orlowska J - Contemp Oncol (Pozn) (2014)

Bottom Line: The TSA category was associated with more frequent COX-2 expression (OR = 7.00, 95% CI: 1.49-32.88, p = 0.014) than HP, but such relation was not found for SSP vs.No associations between COX-2 expression and clinical parameters were found.Immunohistochemical COX-2 expression cannot serve as a diagnostic adjunct to differentiate HP and SSP.

View Article: PubMed Central - PubMed

Affiliation: Clinical Department of Oncology and Hematology, Central Clinical Hospital of the Ministry of Interior in Warsaw, Poland ; Department of Pathology and Laboratory Medicine, Maria Sklodowska-Curie Memorial Cancer Center and Institute of Oncology, Warsaw, Poland.

ABSTRACT

Aim of the study: Cyclooxygenase-2 (COX-2) expression has been observed in a substantial percentage of classical adenomas of the large bowel. The aim of the study was to assess and compare the expression of COX-2 in serrated polyps of the colon.

Material and methods: One hundred and nineteen serrated polyps were analyzed. There were 83 hyperplastic polyps (HP), 19 sessile serrated polyps (SSP) and 17 traditional serrated adenomas (TSA). COX-2 expression was assessed semi-quantitatively (0-2) and each lesion was fully characterized in terms of anatomical location, size, histology, age and sex of the patient. The general estimating equation (GEE) model with logit link was used in the statistical analysis.

Results: Epithelial expression of COX-2 was found in 85/119 serrated polyps (71.43%): 57/83 (68.67%) HP, 16/19 (84.21%) SSP, and 12/17 (70.59%) TSA. In HP and SSP it was predominantly of weak (49/83 HP, 12/19 SSP), whereas in TSA it was mainly of medium/strong intensity (8/17). The TSA category was associated with more frequent COX-2 expression (OR = 7.00, 95% CI: 1.49-32.88, p = 0.014) than HP, but such relation was not found for SSP vs. HP (p > 0.1). No associations between COX-2 expression and clinical parameters were found.

Conclusions: Immunohistochemical COX-2 expression cannot serve as a diagnostic adjunct to differentiate HP and SSP.

No MeSH data available.


Related in: MedlinePlus

A) The hyperplastic polyp epithelium with no COX-2 immunohistochemical expression; magnification 200×, B) The serrated adenoma epithelium exhibits mild COX-2 expression; magnification 100×, C) The sessile serrated polyp epithelium with strong COX-2 expression; magnification 200×
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Figure 0001: A) The hyperplastic polyp epithelium with no COX-2 immunohistochemical expression; magnification 200×, B) The serrated adenoma epithelium exhibits mild COX-2 expression; magnification 100×, C) The sessile serrated polyp epithelium with strong COX-2 expression; magnification 200×

Mentions: One hundred and nineteen serrated polyps of the large bowel were analyzed. There were 83 (69.75%) hyperplastic polyps (HP), 19 (15.97%) sessile serrated polyps (SSP), and 17 (14.29%) traditional serrated adenomas (TSA). In general, 27 serrated polyps (22.69%) were located in the proximal, and 92 (77.31%) in the distal part of the colon. The epithelial expression of COX-2 was found in 85/119 serrated polyps (71.43%): 57/83 (68.67%) HP, 16/19 (84.21%) SSP, and 12/17 (70.59%) TSA. In HP and SSP it was predominantly of weak intensity (49/83 HP, 12/19 SSP), whereas in TSA it was mainly of medium/strong intensity (8/17). Diffuse and microgranular cytoplasmic reaction (Fig. 1) were observed, without marked heterogeneity.


Cyclooxygenase-2 immunohistochemical expression in serrated polyps of the colon.

Kiedrowski M, Mroz A, Kraszewska E, Rembiszewska A, Felisiak-Golabek A, Kupryjanczyk J, Deptala A, Orlowska J - Contemp Oncol (Pozn) (2014)

A) The hyperplastic polyp epithelium with no COX-2 immunohistochemical expression; magnification 200×, B) The serrated adenoma epithelium exhibits mild COX-2 expression; magnification 100×, C) The sessile serrated polyp epithelium with strong COX-2 expression; magnification 200×
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4355662&req=5

Figure 0001: A) The hyperplastic polyp epithelium with no COX-2 immunohistochemical expression; magnification 200×, B) The serrated adenoma epithelium exhibits mild COX-2 expression; magnification 100×, C) The sessile serrated polyp epithelium with strong COX-2 expression; magnification 200×
Mentions: One hundred and nineteen serrated polyps of the large bowel were analyzed. There were 83 (69.75%) hyperplastic polyps (HP), 19 (15.97%) sessile serrated polyps (SSP), and 17 (14.29%) traditional serrated adenomas (TSA). In general, 27 serrated polyps (22.69%) were located in the proximal, and 92 (77.31%) in the distal part of the colon. The epithelial expression of COX-2 was found in 85/119 serrated polyps (71.43%): 57/83 (68.67%) HP, 16/19 (84.21%) SSP, and 12/17 (70.59%) TSA. In HP and SSP it was predominantly of weak intensity (49/83 HP, 12/19 SSP), whereas in TSA it was mainly of medium/strong intensity (8/17). Diffuse and microgranular cytoplasmic reaction (Fig. 1) were observed, without marked heterogeneity.

Bottom Line: The TSA category was associated with more frequent COX-2 expression (OR = 7.00, 95% CI: 1.49-32.88, p = 0.014) than HP, but such relation was not found for SSP vs.No associations between COX-2 expression and clinical parameters were found.Immunohistochemical COX-2 expression cannot serve as a diagnostic adjunct to differentiate HP and SSP.

View Article: PubMed Central - PubMed

Affiliation: Clinical Department of Oncology and Hematology, Central Clinical Hospital of the Ministry of Interior in Warsaw, Poland ; Department of Pathology and Laboratory Medicine, Maria Sklodowska-Curie Memorial Cancer Center and Institute of Oncology, Warsaw, Poland.

ABSTRACT

Aim of the study: Cyclooxygenase-2 (COX-2) expression has been observed in a substantial percentage of classical adenomas of the large bowel. The aim of the study was to assess and compare the expression of COX-2 in serrated polyps of the colon.

Material and methods: One hundred and nineteen serrated polyps were analyzed. There were 83 hyperplastic polyps (HP), 19 sessile serrated polyps (SSP) and 17 traditional serrated adenomas (TSA). COX-2 expression was assessed semi-quantitatively (0-2) and each lesion was fully characterized in terms of anatomical location, size, histology, age and sex of the patient. The general estimating equation (GEE) model with logit link was used in the statistical analysis.

Results: Epithelial expression of COX-2 was found in 85/119 serrated polyps (71.43%): 57/83 (68.67%) HP, 16/19 (84.21%) SSP, and 12/17 (70.59%) TSA. In HP and SSP it was predominantly of weak (49/83 HP, 12/19 SSP), whereas in TSA it was mainly of medium/strong intensity (8/17). The TSA category was associated with more frequent COX-2 expression (OR = 7.00, 95% CI: 1.49-32.88, p = 0.014) than HP, but such relation was not found for SSP vs. HP (p > 0.1). No associations between COX-2 expression and clinical parameters were found.

Conclusions: Immunohistochemical COX-2 expression cannot serve as a diagnostic adjunct to differentiate HP and SSP.

No MeSH data available.


Related in: MedlinePlus