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Expression of cell adhesion molecules in laryngeal carcinoma - preliminary analysis.

Morawski P, Kopta R, Mochocki M, Brzezińska-Błaszczyk E, Lewy-Trenda I, Student Scientific CircleStarska K - Contemp Oncol (Pozn) (2014)

Bottom Line: Tumours with more diffuse growth and infiltrating with small cell groups (< 15/hpf) was characterised by the highest level of adhesive proteins (p = 0.001 and p = 0.02 for sICAM and sVCAM, respectively).Moreover, lower levels of sICAM-1 and sVCAM-1 were observed more frequently in patients who lived longer than five years after treatment.The study indicates the importance of the sICAM and sVCAM expression as indicators of advanced changes and prognosis in patients with laryngeal carcinoma.

View Article: PubMed Central - PubMed

Affiliation: Department of Otolaryngology, Zeromski Specialist Hospital, Krakow, Poland.

ABSTRACT

Aim of the study: Intercellular adhesion molecules present in immunocompetent cells as well as endothelium and tumour cells can regulate cell migration, angiogenesis, apoptosis, proliferation, and metastases in solid tumours. The aim of this study was to analyse the sICAM-1 (soluble intercellular adhesion molecule 1) and sVCAM-1 (soluble vascular cell adhesion molecule 1) expression in peripheral blood mononuclear cell (PBMC) cultures, and to find their relationships with clinicomorphological characteristics in laryngeal cancer.

Materials and methods: The analysis included a group of 50 patients with verified squamous cell carcinoma of the larynx. The control group constituted 30 healthy volunteers. The pathological assessment included pTNM, stage, histological grade, and type of invasion according to the tumour front grading. The expression of adhesion molecules was assessed using the enzyme-linked immunosorbent assay (ELISA).

Results: Increased expression of sICAM-1 and sVCAM-1 was an indicator of more aggressive laryngeal carcinomas. More advanced local changes evaluated on the pT feature were connected with a higher sVCAM-1 (p = 0.017), but not sICAM-1 level. The presence of lymph node metastases correlated with a higher expression of adhesion molecules (p = 0.012 and p = 0.003, for sICAM-1 and sVCAM-1, respectively). Tumours with more diffuse growth and infiltrating with small cell groups (< 15/hpf) was characterised by the highest level of adhesive proteins (p = 0.001 and p = 0.02 for sICAM and sVCAM, respectively). Moreover, lower levels of sICAM-1 and sVCAM-1 were observed more frequently in patients who lived longer than five years after treatment.

Conclusions: The study indicates the importance of the sICAM and sVCAM expression as indicators of advanced changes and prognosis in patients with laryngeal carcinoma.

No MeSH data available.


Related in: MedlinePlus

The concentration of sVCAM-1 in the group studied depending on the 3-year and 5-year survival time
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Figure 0002: The concentration of sVCAM-1 in the group studied depending on the 3-year and 5-year survival time

Mentions: In our study the relationship between survival period (up to 3 years, between 3-5 years, and over 5 years) and the average level of both, sICAM-1 and sVCAM-1, in the PBMC supernatants in SCLC patients was analysed. Statistical analysis disclosed significant differentiation of both adhesion molecule concentrations in relation to patients’ 3- and 5-year survival (p = 0.001 and p = 0.032, respectively). The lower content of both, sICAM-1 and sVCAM-1, in PBMC cultures in patients who lived longer than five years after treatment was observed. The adhesion molecule levels in PBMC cultures in patients with laryngeal carcinoma and statistical analysis results are shown in Fig. 1 and 2.


Expression of cell adhesion molecules in laryngeal carcinoma - preliminary analysis.

Morawski P, Kopta R, Mochocki M, Brzezińska-Błaszczyk E, Lewy-Trenda I, Student Scientific CircleStarska K - Contemp Oncol (Pozn) (2014)

The concentration of sVCAM-1 in the group studied depending on the 3-year and 5-year survival time
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4355661&req=5

Figure 0002: The concentration of sVCAM-1 in the group studied depending on the 3-year and 5-year survival time
Mentions: In our study the relationship between survival period (up to 3 years, between 3-5 years, and over 5 years) and the average level of both, sICAM-1 and sVCAM-1, in the PBMC supernatants in SCLC patients was analysed. Statistical analysis disclosed significant differentiation of both adhesion molecule concentrations in relation to patients’ 3- and 5-year survival (p = 0.001 and p = 0.032, respectively). The lower content of both, sICAM-1 and sVCAM-1, in PBMC cultures in patients who lived longer than five years after treatment was observed. The adhesion molecule levels in PBMC cultures in patients with laryngeal carcinoma and statistical analysis results are shown in Fig. 1 and 2.

Bottom Line: Tumours with more diffuse growth and infiltrating with small cell groups (< 15/hpf) was characterised by the highest level of adhesive proteins (p = 0.001 and p = 0.02 for sICAM and sVCAM, respectively).Moreover, lower levels of sICAM-1 and sVCAM-1 were observed more frequently in patients who lived longer than five years after treatment.The study indicates the importance of the sICAM and sVCAM expression as indicators of advanced changes and prognosis in patients with laryngeal carcinoma.

View Article: PubMed Central - PubMed

Affiliation: Department of Otolaryngology, Zeromski Specialist Hospital, Krakow, Poland.

ABSTRACT

Aim of the study: Intercellular adhesion molecules present in immunocompetent cells as well as endothelium and tumour cells can regulate cell migration, angiogenesis, apoptosis, proliferation, and metastases in solid tumours. The aim of this study was to analyse the sICAM-1 (soluble intercellular adhesion molecule 1) and sVCAM-1 (soluble vascular cell adhesion molecule 1) expression in peripheral blood mononuclear cell (PBMC) cultures, and to find their relationships with clinicomorphological characteristics in laryngeal cancer.

Materials and methods: The analysis included a group of 50 patients with verified squamous cell carcinoma of the larynx. The control group constituted 30 healthy volunteers. The pathological assessment included pTNM, stage, histological grade, and type of invasion according to the tumour front grading. The expression of adhesion molecules was assessed using the enzyme-linked immunosorbent assay (ELISA).

Results: Increased expression of sICAM-1 and sVCAM-1 was an indicator of more aggressive laryngeal carcinomas. More advanced local changes evaluated on the pT feature were connected with a higher sVCAM-1 (p = 0.017), but not sICAM-1 level. The presence of lymph node metastases correlated with a higher expression of adhesion molecules (p = 0.012 and p = 0.003, for sICAM-1 and sVCAM-1, respectively). Tumours with more diffuse growth and infiltrating with small cell groups (< 15/hpf) was characterised by the highest level of adhesive proteins (p = 0.001 and p = 0.02 for sICAM and sVCAM, respectively). Moreover, lower levels of sICAM-1 and sVCAM-1 were observed more frequently in patients who lived longer than five years after treatment.

Conclusions: The study indicates the importance of the sICAM and sVCAM expression as indicators of advanced changes and prognosis in patients with laryngeal carcinoma.

No MeSH data available.


Related in: MedlinePlus