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The effect of tumor volume on radiotherapy outcome and correlation with other prognostic factors in patients with T2 supraglottic cancer.

Rutkowski TW, Maciejewski B, Kołosza Z, Wygoda A, Składowski K, Hejduk B, Rutkowski R - Contemp Oncol (Pozn) (2014)

Bottom Line: Patients with involved nodes, poor histopathological tumor differentiation, or hemoglobin concentration ≤ 14.3 g/dl had significantly larger tumors.Patients with large tumors had significantly lower 5-year local control rate, overall survival rate and presented significantly higher risk of nodal involvement and the ratio of poor histopathological differentiation of the tumor.Tumor volume significantly impacts radiotherapy outcome and should be considered to optimize treatment strategy for patients with T2 supraglottic cancer.

View Article: PubMed Central - PubMed

Affiliation: Department of Radiotherapy and Chemotherapy, Maria Sklodowska-Curie Memorial Cancer Centre and Institute of Oncology, Gliwice Branch, Poland.

ABSTRACT
The retrospective chart review of 110 patients with T2 supraglottic cancer who underwent radiotherapy was performed to correlate tumor volume with other prognostic factors and to analyze its impact on treatment results. Patients with involved nodes, poor histopathological tumor differentiation, or hemoglobin concentration ≤ 14.3 g/dl had significantly larger tumors. Patients with large tumors had significantly lower 5-year local control rate, overall survival rate and presented significantly higher risk of nodal involvement and the ratio of poor histopathological differentiation of the tumor. Tumor volume significantly impacts radiotherapy outcome and should be considered to optimize treatment strategy for patients with T2 supraglottic cancer.

No MeSH data available.


Related in: MedlinePlus

Probability of local control (A) and overall survival (B) of patients with T2 supraglottic cancer in dependence on hemoglobin concentration. Data are stratified into two groups: below the median (Hb ≤ 14.3 g/dl, solid thin line) and above the median (Hb > 14.3 g/dl, dashed line)
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Figure 0002: Probability of local control (A) and overall survival (B) of patients with T2 supraglottic cancer in dependence on hemoglobin concentration. Data are stratified into two groups: below the median (Hb ≤ 14.3 g/dl, solid thin line) and above the median (Hb > 14.3 g/dl, dashed line)

Mentions: Results of univariate analysis shown that when categorized, NTD above 67.3 Gy (median) was correlated with significantly lower LC rate (HR = 2.5, p = 0.02). As a continuous variable Hb was significantly related to OS (p = 0.002). While categorized, Hb above median did not influence LC rate, but was correlated with significantly higher 5-year OS rate (Fig. 2). In multivariate analysis only NTD remained significantly related to LC (Table 5). Hemoglobin together with TV remained significantly related to OS. For 1 g/dl increase of Hb concentration, 24% decreased in the risk of death was supposed. For 1 cm3 increase of TV, 8% increase in the risk of death was supposed (Table 6).


The effect of tumor volume on radiotherapy outcome and correlation with other prognostic factors in patients with T2 supraglottic cancer.

Rutkowski TW, Maciejewski B, Kołosza Z, Wygoda A, Składowski K, Hejduk B, Rutkowski R - Contemp Oncol (Pozn) (2014)

Probability of local control (A) and overall survival (B) of patients with T2 supraglottic cancer in dependence on hemoglobin concentration. Data are stratified into two groups: below the median (Hb ≤ 14.3 g/dl, solid thin line) and above the median (Hb > 14.3 g/dl, dashed line)
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4355652&req=5

Figure 0002: Probability of local control (A) and overall survival (B) of patients with T2 supraglottic cancer in dependence on hemoglobin concentration. Data are stratified into two groups: below the median (Hb ≤ 14.3 g/dl, solid thin line) and above the median (Hb > 14.3 g/dl, dashed line)
Mentions: Results of univariate analysis shown that when categorized, NTD above 67.3 Gy (median) was correlated with significantly lower LC rate (HR = 2.5, p = 0.02). As a continuous variable Hb was significantly related to OS (p = 0.002). While categorized, Hb above median did not influence LC rate, but was correlated with significantly higher 5-year OS rate (Fig. 2). In multivariate analysis only NTD remained significantly related to LC (Table 5). Hemoglobin together with TV remained significantly related to OS. For 1 g/dl increase of Hb concentration, 24% decreased in the risk of death was supposed. For 1 cm3 increase of TV, 8% increase in the risk of death was supposed (Table 6).

Bottom Line: Patients with involved nodes, poor histopathological tumor differentiation, or hemoglobin concentration ≤ 14.3 g/dl had significantly larger tumors.Patients with large tumors had significantly lower 5-year local control rate, overall survival rate and presented significantly higher risk of nodal involvement and the ratio of poor histopathological differentiation of the tumor.Tumor volume significantly impacts radiotherapy outcome and should be considered to optimize treatment strategy for patients with T2 supraglottic cancer.

View Article: PubMed Central - PubMed

Affiliation: Department of Radiotherapy and Chemotherapy, Maria Sklodowska-Curie Memorial Cancer Centre and Institute of Oncology, Gliwice Branch, Poland.

ABSTRACT
The retrospective chart review of 110 patients with T2 supraglottic cancer who underwent radiotherapy was performed to correlate tumor volume with other prognostic factors and to analyze its impact on treatment results. Patients with involved nodes, poor histopathological tumor differentiation, or hemoglobin concentration ≤ 14.3 g/dl had significantly larger tumors. Patients with large tumors had significantly lower 5-year local control rate, overall survival rate and presented significantly higher risk of nodal involvement and the ratio of poor histopathological differentiation of the tumor. Tumor volume significantly impacts radiotherapy outcome and should be considered to optimize treatment strategy for patients with T2 supraglottic cancer.

No MeSH data available.


Related in: MedlinePlus