Limits...
Trans-arterial Onyx Embolization of a Functional Thoracic Paraganglioma.

Chacón-Quesada T, Rodriguez GJ, Maud A, Ramos-Duran L, Torabi A, Fitzgerald T, Akle N, Cruz Flores S, Trier T - Neurointervention (2015)

Bottom Line: They are highly vascular and in some cases hormonally active, making their management challenging.Although there is strong evidence of the safety and effectiveness of preoperative embolization in the management of spinal tumors, only five cases have been reported in the setting of thoracic paragangliomas.We present the case of a 19-year-old man with a large, primary, functional, malignant paraganglioma of the thoracic spine causing a vertebral fracture and spinal cord compression.

View Article: PubMed Central - PubMed

Affiliation: Center of Excellence in Neurosciences, Texas Tech University Health Sciences Center, Paul L. Foster School of Medicine, EL Paso, TX, USA.

ABSTRACT
Paragangliomas are rare tumors of the endocrine system. They are highly vascular and in some cases hormonally active, making their management challenging. Although there is strong evidence of the safety and effectiveness of preoperative embolization in the management of spinal tumors, only five cases have been reported in the setting of thoracic paragangliomas. We present the case of a 19-year-old man with a large, primary, functional, malignant paraganglioma of the thoracic spine causing a vertebral fracture and spinal cord compression. To our knowledge this is the first report of preoperative trans-arterial balloon augmented Onyx embolization of a thoracic paraganglioma.

No MeSH data available.


Related in: MedlinePlus

Pathology. A. Nests of tumor cells (Zellballen) composed of uniform cells with round nuclei, eosinophil cytoplasm in a highly vascular stroma (Haematoxylin and Eosin, 40×). B. Inmmunohistochemical staining of the tumor showing positivity for Chromogranin (10×). C. A tumor measuring 10×7×3 cm resected in the second surgery. Microscopic examination of the resected mass evidence D) 50% coagulative necrosis of the tumor (black arrow) with the embolic material completely occluding an artery, and E) some viable tumor cells after the embolization (black arrows) (Haematoxylin and Eosin, 10×).
© Copyright Policy - open-access
Related In: Results  -  Collection

License
getmorefigures.php?uid=PMC4355644&req=5

Figure 3: Pathology. A. Nests of tumor cells (Zellballen) composed of uniform cells with round nuclei, eosinophil cytoplasm in a highly vascular stroma (Haematoxylin and Eosin, 40×). B. Inmmunohistochemical staining of the tumor showing positivity for Chromogranin (10×). C. A tumor measuring 10×7×3 cm resected in the second surgery. Microscopic examination of the resected mass evidence D) 50% coagulative necrosis of the tumor (black arrow) with the embolic material completely occluding an artery, and E) some viable tumor cells after the embolization (black arrows) (Haematoxylin and Eosin, 10×).

Mentions: An ultrasound guided biopsy confirmed it to be a paraganglioma (Fig. 3A and 3B). There was no history of any associated familial syndromes and genetic testing did not display any known abnormality.


Trans-arterial Onyx Embolization of a Functional Thoracic Paraganglioma.

Chacón-Quesada T, Rodriguez GJ, Maud A, Ramos-Duran L, Torabi A, Fitzgerald T, Akle N, Cruz Flores S, Trier T - Neurointervention (2015)

Pathology. A. Nests of tumor cells (Zellballen) composed of uniform cells with round nuclei, eosinophil cytoplasm in a highly vascular stroma (Haematoxylin and Eosin, 40×). B. Inmmunohistochemical staining of the tumor showing positivity for Chromogranin (10×). C. A tumor measuring 10×7×3 cm resected in the second surgery. Microscopic examination of the resected mass evidence D) 50% coagulative necrosis of the tumor (black arrow) with the embolic material completely occluding an artery, and E) some viable tumor cells after the embolization (black arrows) (Haematoxylin and Eosin, 10×).
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4355644&req=5

Figure 3: Pathology. A. Nests of tumor cells (Zellballen) composed of uniform cells with round nuclei, eosinophil cytoplasm in a highly vascular stroma (Haematoxylin and Eosin, 40×). B. Inmmunohistochemical staining of the tumor showing positivity for Chromogranin (10×). C. A tumor measuring 10×7×3 cm resected in the second surgery. Microscopic examination of the resected mass evidence D) 50% coagulative necrosis of the tumor (black arrow) with the embolic material completely occluding an artery, and E) some viable tumor cells after the embolization (black arrows) (Haematoxylin and Eosin, 10×).
Mentions: An ultrasound guided biopsy confirmed it to be a paraganglioma (Fig. 3A and 3B). There was no history of any associated familial syndromes and genetic testing did not display any known abnormality.

Bottom Line: They are highly vascular and in some cases hormonally active, making their management challenging.Although there is strong evidence of the safety and effectiveness of preoperative embolization in the management of spinal tumors, only five cases have been reported in the setting of thoracic paragangliomas.We present the case of a 19-year-old man with a large, primary, functional, malignant paraganglioma of the thoracic spine causing a vertebral fracture and spinal cord compression.

View Article: PubMed Central - PubMed

Affiliation: Center of Excellence in Neurosciences, Texas Tech University Health Sciences Center, Paul L. Foster School of Medicine, EL Paso, TX, USA.

ABSTRACT
Paragangliomas are rare tumors of the endocrine system. They are highly vascular and in some cases hormonally active, making their management challenging. Although there is strong evidence of the safety and effectiveness of preoperative embolization in the management of spinal tumors, only five cases have been reported in the setting of thoracic paragangliomas. We present the case of a 19-year-old man with a large, primary, functional, malignant paraganglioma of the thoracic spine causing a vertebral fracture and spinal cord compression. To our knowledge this is the first report of preoperative trans-arterial balloon augmented Onyx embolization of a thoracic paraganglioma.

No MeSH data available.


Related in: MedlinePlus